Behaviour of Disc Oedema During and After Amiodarone Optic Neuropathy: Case Report

Shah

J Innov Cardiac Rhythm Manage

et al. 2020

Amiodarone is commonly used for a variety of arrhythmias and, in some parts of the world, is the only available antiarrhythmic drug (AAD). Yet, amiodarone is known to have a wide range of potential side effects, many of which are dose-and duration-dependent. We sought to study the incidence of side effects leading to the discontinuation of low-dose amiodarone, arbitrarily defined as 200 mg/day or less, and very-low-dose amiodarone, defined as 100 mg/ day or less. In this study, literature databases were searched through June 2019. Studies that reported the incidence or prevalence of side effects of amiodarone were included. Effect estimates from individual studies were extracted and combined using the random-effects generic inverse variance method of DerSimonian and Laird. A total of 10 observational cohort studies involving 901 patients were included in the analysis. The pooled estimated incidence of overall side effects for low-dose amiodarone was 0.17 [95% confidence interval (CI): 0.12-0.22]. In addition, the pooled estimated incidence of side effects requiring medication discontinuation was 0.06 (95% CI: 0.03-0.11). As compared with 200 mg/day of amiodarone, the pooled estimated incidence of overall side effects was 0.11 (95% CI: 0.04-0.27), while the incidence of side effects requiring medication discontinuation was 0.02 (95% CI: 0.01-0.06) for the dose of 100 mg/day. In conclusion, verylow-dose amiodarone displays a low incidence of significant side effects requiring medication discontinuation.

Section: Safety Of Low-dose Amiodaronementioning

confidence: 99%

Section: Safety Of Low-dose Amiodaronementioning

confidence: 99%

Low-dose Amiodarone Is Safe: A Systematic Review and Meta-analysis

Shah

J Innov Cardiac Rhythm Manage

et al. 2020

“…As a mechanism, we note the accumulation of cytoplasmic inclusions in lysosomes. OCT changes show RNFL thickening in early stages, followed by axonal loss and optical atrophy [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

The role of Optical Coherence Tomography in optic neuropathies

Iorga

Moraru

Ozturk

et al. 2018

rjo

Optical neuropathies are neuro-ophthalmologic disorders, the main symptoms of which are the decrease of visual acuity and the alteration of the color vision. Optical coherence tomography has been one of the most important innovations in ophthalmology, which offered the possibility to analyze specific structures of the retina. Optical coherence tomography performs in vivo, real-time, noncontact scanning and provides cross-sectional and volumetric images with a resolution approaching that of histology. Optical coherence tomography offers the opportunity to study neurological diseases in an objective and non-invasive manner. The measurements of retinal nerve fiber layer can be an objective measurement of nerve swelling or nerve atrophy. By analyzing the ganglion cell complex, optical coherence tomography can help detect early axonal damage and may predict the visual outcome. It can be useful for diagnosis and follow-up of optic nerve and chiasmal compressive diseases. Furthermore, optical coherence tomography is useful in patients with multiple sclerosis in distinguishing macular disease from optic neuritis and in monitoring the treatment. Multiple studies and clinical observations support the importance of optical coherence tomography in the diagnosis, treatment, and follow-up of optic neuropathies.Abbreviations: OCT = optical coherence tomography, VA = visual acuity, RNFL = retinal nerve fiber layer, GCL = ganglion cells layer, MS = multiple sclerosis, ON = optic neuropathy, NAION = non-arteritic ischemic anterior optic neuropathy, LHON = Leber hereditary optic neuropathy, RE = right eye, LE = left eye

Офтальмология. Восточная Европа

“…На ранних стадиях токсичность накапливается в митохондриях ганглиозных клеток, вызывая утолщение аксонов, которое выявляется при ОКТ отеком перипапиллярной сетчатки [25]. На подострой стадии ОКТ показывает RNFL-истончение папилломакулярного пучка в нижнем и верхнем секторах.…”

Section:  обсуждениеunclassified

Длительная Нейропротекция Зрительного Нерва После Токсического Поражения Метанолом (Экспериментально-Клинические Наблюдения)

Guzun¹,

Khramenko²,

Коновалова³

et al. 2021

Проведенное экспериментально-клиническое исследование показывает необходимость и эффективность предложенного комплекса лечебных мероприятий при токсическом (метаноловом) поражении зрительного нерва, направленного на улучшение метаболических процессов и кровообращения, что способствует восстановлению миелиновой оболочки вокруг осевых цилиндров волокон зрительного нерва и, соответственно, ведет к ускорению проведения потенциала действия на возрождение анализа зрительной информации. Курс нейропротекторного лечения включает курсы низкоинтенсивной лазерной терапии сетчатки/ДЗН каждые 6 месяцев с непрерывной поддержкой не менее 3 лет витаминно-антиоксидантным комплексом Нутроф® Форте формулы AREDS, усиленной витамином D3, омега-3 ПНЖК и ресвератролом (1 мг). Thus, the conducted experimental-clinical study shows the necessity and effectiveness of the proposed complex of therapeutic measures for toxic (methanol) damage to the optic nerve, aimed at improving metabolic processes and blood circulation, which contributes to the restoration of the myelin sheath around the axial cylinders of the optic nerve fibers and, accordingly, leads to accelerating the implementation of the action potential for the revival of the analysis of visual information. The course of neuroprotective treatment includes courses of low-intensity laser therapy of the retina / optic nerve disc every 6 months with continuous support with a vitamin-antioxidant complex of the AREDS formula, fortified with vitamin D3, omega-3 PUFA and resveratrol (1 mg) (Nutrof ® Forte), which should be carried out at least 3 years.