The role of Optical Coherence Tomography  in optic neuropathies

Iorga, Raluca Eugenia; Moraru, Andreea; Ozturk, Manuela Ramona; Costin, D

doi:10.22336/rjo.2018.2

Cited by 30 publications

(24 citation statements)

References 41 publications

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“…Toxic optic neuropathy was the second most common condition which was encountered in this study. Past studies have also revealed reduced thickness of RNFL among the patients of toxic optic neuropathy which was supported by the present analysis as well 8 .…”

Section: Discussionsupporting

confidence: 90%

“…It is also useful in providing a non-invasive tool to diagnose a lot of neurological illnesses 7 . Patients with optic neuropathies also get benefit from this investigation technique both in terms of diagnosis and observing the response of treatment 8 . This multipurpose diagnostic modality has been utilized both in clinical settings and research purpose 9 .…”

Section: Introductionmentioning

confidence: 99%

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Quantification of Retinal Nerve Fiber Layer for Early Detection of Anterior Visual Pathway Lesions

Malik

Naqvi²,

Arsalan³

2021

PAFMJ

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Objective: To assess the role of quantification of retinal nerve fiber layer for early detection of anterior visualpathway lesions. Study Design: Case-control study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Jan to Jul 2019. Methodology: A total of 100 cases of anterior visual pathway lesions of varying clinical presentations wereincluded in the study. There were 100 matched controls who were selected from the community without anyophthalmological abnormality using non-probability consecutive sampling technique. Retinal nerve fiber layer(RNFL) thickness was measured with the help of optical coherence tomography in both the cases and controls.Mean retinal nerve fiber layer values were compared in both the groups. Student’s t-test was applied to look forany significant difference between the two groups. Results: Mean age of the patients was 39.14 ± 3.925 years while mean age of the controls was 39.23 ± 2.415 years. Mean retinal nerve fiber layer thickness in the case group was 72.21 ± 9.615 µm while on the control group was 101.34 ± 9.615 µm. A statistically significant difference was observed between cases and controls in terms of mean retinal nerve fiber layer thickness (p<0.001). Subjects with retinal nerve fiber layer thickness <85 µm were more likely to exhibit anterior visual pathway lesions (OR= 15.915 [6.278-40.346]; 95% CI, p<0.001). Conclusion: Decreased retinal nerve fiber layer thickness can serve as a predictor for anterior visual pathwaylesions. Optical coherence tomography should be incorporated for routine screening of high-risk cases in order to identify anterior visual pathway lesions in time.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Quantification of Retinal Nerve Fiber Layer for Early Detection of Anterior Visual Pathway Lesions

Malik

Naqvi²,

Arsalan³

2021

PAFMJ

View full text Add to dashboard Cite

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“…11 In fact, it can be said with authority that this imaging tool is nowadays a routine part of ophthalmology practice to identify macular lesions. 12 The role of OCT is also pivotal in detecting other eye-related conditions like hyper-reflectivity due to macular telangiectasia type-2, 13 optic neuropathies, 14 and glaucomatous retinal nerve fiber layer loss. 15 Papilledema is a serious medical condition that leads to visual disturbances and occurs due to the optic disc's swelling because of increased intraocular pressure; 16,17 OCT technique can be used to measure the amount of optic disc edema in this condition.…”

Section: Ophthalmologymentioning

confidence: 99%

Optical coherence tomography’s current clinical medical and dental applications: a review

Ali

Gilani

Shabbir³

et al. 2021

F1000Res

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Optical coherence tomography (OCT) is a non-invasive investigative technique that is used to obtain high-resolution three-dimensional (3D) images of biological structures. This method is useful in diagnosing diseases of specific organs like the eye, where a direct biopsy cannot be conducted. Since its inception, significant advancements have been made in its technology. Apart from its initial application in ophthalmology for retinal imaging, substantial technological innovations in OCT brought by the research community have enabled its utilization beyond its original scope and allowed its application in many new clinical areas. This review presents a summary of the clinical applications of OCT in the field of medicine (ophthalmology, cardiology, otology, and dermatology) and dentistry (tissue imaging, detection of caries, analysis of dental polymer composite restorations, imaging of root canals, and diagnosis of oral cancer). In addition, potential advantages and disadvantages of OCT are also discussed.

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“…Optical coherence tomography (OCT) stands out from the available methods as it has been used for more than three decades (Petzold et al 2017). It involves a noninvasive cross‐sectional imaging of the retina to assess changes in the retinal nerve fibre layer (RNFL) and, in more recent studies (Iorga et al 2018; Pillay et al 2018), changes in the ganglion cell layer. The decrease in the RNFL thickness correlates with degenerative processes (Park et al 2014; Britze & Frederiksen 2018).…”

Section: Introductionmentioning

confidence: 99%

Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis associated with multiple sclerosis in a 6‐month follow‐up

Svrčinová

Hok

Šínová

et al. 2020

Acta Ophthalmologica

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Purpose Optic neuritis (ON) is an inflammatory demyelinating disorder of the optic nerve, which can be the first manifestation of multiple sclerosis (MS). The main goal was to assess changes in the retinal nerve fibre layer (RNFL) and in retinal oxygen saturation [arterial (AS), venous (VS) and arterio‐venous (A‐V) difference] in the affected and unaffected eye. Methods Fifty patients with ON due to MS within 3 months of onset of symptoms were enrolled (17 males, mean age 35.3). All patients were examined at baseline (V1) and after 6 months (V2) using optical coherence tomography (OCT) to get RNFL values; automatic retinal oximetry to obtain saturation values; and ultrasound to exclude arterial stenosis, and orbital colour Doppler imaging was performed in the ophthalmic artery. Results At V1, AS was significantly increased in affected eye compared to unaffected eye (99.5% versus 98.0%, p = 0.03). Significant decrease in A‐V difference from baseline was detected in both eyes for ON eye: 32.0% versus 29.0%, p = 0.004; for fellow eye: 31.4% versus 30.0%, p = 0.04. We did not observe any changes in retinal vessel diameter. There were no changes observed in blood flow in ophthalmic artery. At V1, there were no significant differences in RNFL, and significant loss of RNFL was confirmed in the affected eye at V2 (95 μm versus 86 μm, p = 0.0002) and in comparison with the fellow eye (86 μm versus 94 μm, p = 0.0002). There were no correlations between RNFL and saturation values at V1, although at V2, there was a negative correlation between the RNFL and AS (Spearman's rho = −0.480, p = 0.003) and between the RNFL and VS (rho = −0.620, p = 0.00007). Conclusion Retinal oximetry is altered in both eyes in MS patients with unilateral ON. During the course of the disease, the retinal oxygen consumption decreases to a different degree in each eye and this change is not completely followed by changes in the RNFL thickness, suggesting either sub‐clinical ON or systemic effects in the clinically unaffected eye. Since this is the first and initial longitudinal evaluation of the saturation changes in MS patients, the clinical value of these findings needs to be deeper evaluated in the future studies.

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The role of Optical Coherence Tomography in optic neuropathies

Cited by 30 publications

References 41 publications

Quantification of Retinal Nerve Fiber Layer for Early Detection of Anterior Visual Pathway Lesions

Quantification of Retinal Nerve Fiber Layer for Early Detection of Anterior Visual Pathway Lesions

Optical coherence tomography’s current clinical medical and dental applications: a review

Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis associated with multiple sclerosis in a 6‐month follow‐up

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