Behaviour of the Free Erythrocyte Protoporphyrins and of the Erythrocyte Copper in Iron Deficiency Anaemias

Erythrocyte <i>δ</i>-Aminolaevulinic Acid Dehydratase, Urinary Porphyrins and Porphyrin Precursors in Iron Deficiency Anaemia

“…Thus, various authors confirmed that in this condition the free erythrocyte protoporphyrin (EPP) is increased [8,14,16; Lyberatos et cl., unpublished data]. Fur thermore, Dagg et al [4] found a similar increase even in sideropenic subjects without obvious iron deficiency anaemia.…”

Relation of Porphyrin Content to Red Cell Age: Analysis by Fractional Hemolysis

“…Thus, in patients with iron deficiency anemia, values fall within 2-3 weeks (or less) to about the pretreatment values, generally after a lag of about 3-7 days (2, 14,16). This lag phase and the persistence for 2-4 weeks of a relatively constant rate of decline in porphyrin concentration with half-times of about 10-15 days both suggest that the administered iron does not act by complexing already existing erythrocyte proto, but rather prevents accumulation of newly formed proto by permitting complete heme synthesis in immature and reticulocytes were increased, reticulocytes tended to be fluorocytes, but most fluorocytes were not reticulocytes.…”

Erythrocyte Delta-Ammo-Laevulinic Acid Dehydrase in Anaemia

“…A similar behaviour in relation to treatment can be observed in macrocytic anaemias. In this connection it is interesting to recall a recent report by I odice et al (7) that ALA-D is probably a copper containing enzyme, and the observation that erythrocyte copper and free protoporphyrin appeared to be closely related (14,11).…”