Behaviour of Tumours in Conditions of Experimental Magnesium Deficiency

Mills, F. H.

doi:10.1016/s0140-6736(74)90977-5

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…Such effect of Mg deprivation was indeed specific, as switching back to Mg-supplemented diet restored tumor growth. In the same studies dietary restriction of Mg was found to potentiate the anticancer activity of a variety of chemotherapeutic agents (22). Whereas these findings highlighted Mg as a key factor of tumor growth and perhaps drug-sensitivity, other studies in SV 40transformed human lung fibroblasts revealed that these cells could grow in the face of Mg removal from the culture medium (23)(24)(25).…”

Section: The Effect Of Extracellular Mg On Cell Proliferationmentioning

confidence: 99%

Magnesium in cell proliferation and differentiation

Wolf

Cittadini²

1999

Front Biosci

122

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Compelling evidence shows that magnesium (Mg) content is directly correlated to proliferation in normal cells as Mg stimulates DNA and protein synthesis. Some data have demonstrated that upon mitogenic stimuli normal cell are able to increase their intracellular Mg content, likely by activating Mg influx. Mg deprivation, in turn, induces inhibition of DNA and protein synthesis thus promoting growth arrest. From a mechanistic viewpoint, Mg deprivation may influence cell cycle control by upregulating the cyclin inhibitor p27Kip1 thus influencing cyclin E-dependent kinases. In many neoplastic cells, Mg is higher than in normal counterparts and this high Mg is maintained also against concentration gradient. Moderate vs. severe and acute vs chronic effect of Mg deprivation must be distinguished: severe Mg deprivation causes growth arrest also in tumor cells, while chronic Mg deprivation leads to an "adaptation" of tumor cells both to growth rate and Mg content. In tumor cells deranged Mg content and distribution is likely due to an inhibition of Mg efflux via the Na-Mg antiport. When differentiation process is induced by receptor mediated stimuli such as IFN-alpha and ATP, decrease of cell Mg content accompanies with activation of Mg efflux. Transformed cells may thus display high growth rate also because they retain a large amount of Mg. On their whole, these data strongly suggest that regulation of intracellular Mg availability parallels the molecular control of cell proliferation, and maybe also cell differentiation and death.

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Section: The Effect Of Extracellular Mg On Cell Proliferationmentioning

confidence: 99%

Magnesium in cell proliferation and differentiation

Wolf

Cittadini²

1999

Front Biosci

122

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The effects of dietary deficiencies of magnesium and potassium on the growth and chemistry of transplanted tumours and host tissues in the rat

Young

Parsons

1977

European Journal of Cancer (1965)

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Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice

Nasulewicz

Wietrzyk

Wolf

et al. 2004

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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The results of several experimental and epidemiological studies have shown an inverse correlation between Mg status and the risk of some cancers. However, relationship between magnesium and cancer is complex. The aim of our work was to examine the precise effect of Mg deficiency on transplantable mouse tumor growth and metastasis. The results obtained indicate a significant retardation of primary tumor growth (up to 70%) in mice receiving Mg-deficient diet. However, Mg repletion caused in these mice significant increase of primary tumor burden. Analysis of cell cycle distribution showed a reduced percentage of cells in the S phase and an increase of cells in the G(0)/G(1) phase of the cell cycle in LLC tumors caused by Mg deficiency. This is in agreement with the effect of low Mg level on cell growth observed in vitro. Interestingly, in mice inoculated with LLC cells and receiving low-magnesium diet, a higher metastatic potential was observed as compared to control mice. In conclusion, our results demonstrate a direct role of magnesium in tumor growth and also point at deleterious effect of low magnesium status on tumor metastasis.

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Behaviour of Tumours in Conditions of Experimental Magnesium Deficiency

Cited by 7 publications

References 6 publications

Magnesium in cell proliferation and differentiation

Magnesium in cell proliferation and differentiation

The effects of dietary deficiencies of magnesium and potassium on the growth and chemistry of transplanted tumours and host tissues in the rat

Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice

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