Behavioural addictions in bipolar disorder patients: Role of impulsivity and personality dimensions

Nicola, Marco Di; Tedeschi, D.; Mazza, Marianna; Martinotti, Giovanni; Harnic, Désirée; Catalano, Valeria; Bruschi, Angelo; Pozzi, Gino; Bria, Pietro; Janiri, Luigi

doi:10.1016/j.jad.2009.12.016

Cited by 93 publications

(54 citation statements)

References 43 publications

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“…These experiences define bipolar disorder (BD), and are usually invoked to explain other risky behaviors such as alcohol use disorders (AUDs), other addictions, and suicidality also associated with the disorder (Swann et al, 2005;Merikangas et al, 2007;Di Nicola et al, 2010). However, the neural basis for such behavior is not yet established.…”

Section: Introductionmentioning

confidence: 99%

“…This low level of response in completely antipsychotic-naive subjects could reflect neurodevelopmental alterations-eg, in dopaminergic transmission (Bahi and Dreyer, 2012) or in white matter pathway development )-relating to the elevated rates of both substance and nonsubstance addictions observed across BD subtypes (Swann et al, 2005;Merikangas et al, 2007;Di Nicola et al, 2010;Swann, 2010). From this perspective, altered neural processing of rewards may be a shared risk-factor between BD and addictive disorders (Yip et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder

Yip

Worhunsky

Rogers

et al. 2014

Neuropsychopharmacol

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Increased activity within known reward-processing neurocircuitry (eg, ventral striatum, VS) has been reported among medicated individuals with bipolar disorder (BD) I and II. However, such findings are confounded by the potential ameliorative effects of moodstabilizing and antipsychotic medications on neural activations. This study tests the hypothesis that a pathophysiological locus of alterations in reward processing is present within the striatum in antipsychotic and lithium-naive individuals with BD. Twenty antipsychotic and lithium-naive individuals with BD II or BD not-otherwise specified (NOS) and 20 matched healthy comparison individuals participated in functional magnetic resonance imaging during the performance of a monetary incentive delay task. Between-group comparisons were conducted using small-volume correction focusing on orthogonal a priori regions of interest centered in the VS and dorsal striatum (DS), respectively. During reward anticipation, unmedicated individuals with BD II/NOS had decreased activity within the DS (but not VS). During loss anticipation, on the other hand, decreased activation within both the VS and DS was observed. Across all participants, DS activity (during reward anticipation) was positively associated with putamen volume. This is the first report of decreased dorsal and ventral striatal activity among unmedicated individuals with BD II/NOS. These data contradict a simple 'reward hypersensitivity' model of BD, and add to a growing body of literature suggesting that blunted reward processing may be a vulnerability factor for both mood-and addiction-related disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder

Yip

Worhunsky

Rogers

et al. 2014

Neuropsychopharmacol

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“…Bipolar disorder (BD) is frequently associated with gambling disorder because it is characterized by a predisposition to suicide behavior and impulsivity (43,44). A bipolar disorder diagnosis and impulsive conduct (such as gambling disorder, alcohol and drug use, and abuse) has been identified in more men than women according to the scientific data (45).…”

Section: Newman and Thompson (25)mentioning

confidence: 99%

Gambling Disorder and Suicide: An Overview of the Associated Co-Morbidity and Clinical Characteristics

Martinotti

Sarchione

Fiori

et al. 2016

Int J High Risk Behav Addict

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Context: A high prevalence of suicide and attempted suicide in relation to gambling disorder is in increasing evidence in current scientific data. The objective of this review was to explore if there was a primary correlation between psychiatric co-morbidities and gambling and/or a secondary correlation with suicide acts. Evidence Acquisition: We performed a critical analysis of the most recent papers in the scientific literature in this regard and report on the most significant findings. Results: A direct relationship between gambling and suicidality was highlighted in a number of European, American, and Asian countries. However, it was not clear whether or not gambling increased the risk of suicidal behavior. Two general trends were noted. The first was that gamblers with extreme gambling behavior incurred economic losses and debts to such an extent that suicidal acts appeared to be the only solution. The second was that suicidal acts by gamblers were precipitated by interpersonal and/or working challenges, in conjunction with personality traits of impulsivity and psychiatric co-morbidities. Conclusions: A combination of impulsivity, certain psychiatric disorders, and social factors may explain the frequent occurrence of suicidal behavior in gamblers.

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“…DiNicola and associates [25] included cyclothymic disorder as well as bipolar I and II in their study of 158 outpatients with bipolar disorders and behavioral addictions. They drew comparison with a matched control group of 200 non-bipolar subjects.…”

Section: Literature Reviewmentioning

confidence: 99%

DSM-IV Axis I Psychopathology in Males with Non-Paraphilic Hypersexual Disorder

Kafka

2015

Curr Addict Rep

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Non-paraphilic hypersexual disorder, also described as sexual addiction/compulsivity, is associated with significant, adverse, social, and public health consequences. Despite differences in their appellative designation, this condition is commonly associated with psychiatric Axis I (and Axis II) comorbidities. The extant and recent clinical and research describing concurrent Axis I diagnoses is reviewed. Despite methodological differences in assessment, hypersexual disorder shares a high degree of Axis I comorbidity with both unipolar and bipolar mood disorders, anxiety disorders, especially generalized and social anxiety, attention-deficit hyperactivity disorder-inattentive subtype, and psychoactive substance-abuse disorders. The aforementioned Axis I disorders, like hypersexual disorder, also share early age of onset and association with other sensation-seeking and risk-taking behaviors.

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Behavioural addictions in bipolar disorder patients: Role of impulsivity and personality dimensions

Cited by 93 publications

References 43 publications

Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder

Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder

Gambling Disorder and Suicide: An Overview of the Associated Co-Morbidity and Clinical Characteristics

DSM-IV Axis I Psychopathology in Males with Non-Paraphilic Hypersexual Disorder

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