Behavioural and haematological studies on effects of lycopene in Wistar rats subjected to psychological stress

Ogundeji, T. P.; Ayo, Joseph Olusegun; Aluwong, Tagang; Mohammed, Aliyu

doi:10.5897/jnbh12.014

Cited by 6 publications

(9 citation statements)

References 24 publications

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“…This agrees with the reports of Mohammed et al [23] and Krishna et al [34] who demonstrated that blood glucose level was increased significantly after 72 hours of STZ injection to Wistarrats. Streptozotocin has been shown to induce diabetes which is similarto human hyperglycaemic non-ketotic diabetes mellitus in animal models.…”

Section: Discussionsupporting

confidence: 83%

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Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Daniel¹

2015

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Abstract:The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.

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Section: Discussionsupporting

confidence: 83%

“…It was reconstituted in olive oil (Goya en espana, S.A.U., Savilla, Spain) to appropriate working dosage as earlier described by Ogundejiet al [23] with modifications. All other chemicals andsolvents used were of analytical grade.…”

Section: Chemicals and Lycopenementioning

confidence: 99%

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Daniel¹

2015

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“…It is a measure of erythrocyte strength and its ability to withstand varying osmotic gradients and it has being reported to be increased during oxidative stress [58] [59]. The greater the erythrocyte osmotic fragility, the weaker the tensile strength of erythrocyte membrane [23]. Similarly, hyperglycaemia associated with diabetes has been shown to increase the erythrocyte osmotic fragility and membrane lipid peroxidation in human erythrocytes [60].…”

Section: Discussionmentioning

confidence: 99%

“…30 mg lycopene in a gelatinous capsule was reconstituted in olive oil to appropriate working doses as described by Ogundeji et al [23] with little modifications. All treatments were administered orally once daily for a period four (4) weeks.…”

Section: Experimental Designmentioning

confidence: 99%

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Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

Eze¹,

Tanko²,

Ahmed³

et al. 2017

JDM

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Introduction: Diabetes mellitus has remained one of the serious health problems in the world; and oxidative stress has been reported to be a root cause for the progression and development of diabetes mellitus and its associated complications. Aim: This study investigated the possible ameliorative effects of lycopene on diabetic-induced changes in erythrocyte osmotic fragility and lipid peroxidation in Wistar rats. Methodology: The animals were made diabetic by single intraperitoneal injection of streptozotocin at 60 mg/kg b w. Diabetes was confirmed by the presence of high fasting blood glucose level ≥ 200 after 72 hours. Thereafter, diabetic rats were randomly assigned into six groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Group 1 (Diabetic control) and group 2 (Normal control) rats received 0.5 ml of olive oil, groups 3, 4, 5 rats received 10, 20, 40 mg/kg bw of lycopene respectively, while those in group 6 received 2 mg/kg bw of glibenclamide orally once daily for a period of four weeks. At the end of the treatment, all animals were sacrificed; blood samples collected for determination of erythrocyte osmotic fragility (EOF) and lipid peroxidation (LPO). Results: The results obtained showed that there was a significantly (P < 0.05) lowered erythrocyte osmotic fragility in diabetic animals treated with lycopene when compared with diabetic control group. In addition, there was also a significantly (P < 0.05) reduced erythrocyte malondialdehyde concentration, an index of lipid peroxidation in the diabetic treated groups when compared with diabetic control group. Conclusion: From the available findings, it can be concluded that administration of lycopene to diabetic rats attenuated diabetic-induced changes in EOF and LPO and these observed effects may be attributed to anti-oxidative property of lycopene.

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Effect of Diabetes Mellitus and Hypertension on Osmotic Fragility and Hemorheological Factors in Male Wistar Rats

et al. 2021

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Diabetes mellitus is a common risk factor for erythrocyte osmotic stress. This study was aimed at exploring the effect of streptozotocin (STZ)-induced diabetes mellitus and salt-induced hypertension on osmotic fragility and hemorheological variables in male Wistar rats. Thirty male rats were grouped into five groups of six animals each as follows: negative control (zero salt in diet); positive control (normal salt diet - 0.3% salt); high salt diet (8% salt) (HSD only); STZ induced diabetes and normal salt diet (STZ only); STZ induced diabetes and high salt diet (STZ + HSD). At the end of a 4 weeks period, hematological variables, osmotic fragility, rheology and cardiovascular responses were assessed. There was an increase (p<0.05) in the mean arterial pressure and heart rate of HSD, STZ and HSD + STZ groups indicating a salt induced hypertension. There was a decrease in the body weight of STZ and HSD +STZ groups. There was significant increase (p<0.05) in the haematocrit, platelets estimates and fibrinogen concentrations in the experimental groups when compared with the controls. The STZ and STZ + HSD groups showed a reduced clotting time which corresponded to the increased platelet estimates and fibrinogen concentration. The increase in haematocrit, platelet and plasma protein resulted in the increased blood viscosity and a decreased flow rate. The osmotic fragility test was also observed to be increased (p<0.05) in HSD, STZ only and STZ + HSD groups. Diabetes mellitus and hypertension increase the rate of hemolysis of erythrocyte, as well as increase blood viscosity.

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Behavioural and haematological studies on effects of lycopene in Wistar rats subjected to psychological stress

Cited by 6 publications

References 24 publications

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

Effect of Diabetes Mellitus and Hypertension on Osmotic Fragility and Hemorheological Factors in Male Wistar Rats

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