Behavioural and physiological consequences of a single social defeat in Roman high- and low-avoidance rats

Meerlo, Peter; Overkamp, Gerard; Koolhaas, J.M.

doi:10.1016/s0306-4530(96)00047-9

Cited by 95 publications

(51 citation statements)

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“…It also supports the concept of "reactive" versus "spontaneous" locomotor activity (Courvoisier et al 1996;Gentsch et al 1991). Interestingly, and in contrast to other studies that have demonstrated long-term changes in the amplitude of the circadian rhythm in body temperature, activity, and food intake following a 1-h social defeat (Meerlo et al 1996(Meerlo et al , 1997 or in activity and water intake after electric tailshock (Scott et al 1996), the amplitude of the diurnal rhythm of all parameters measured in the present experiment had already returned to baseline values on the day following social defeat ( Figure 3). However, increased daytime body temperature ( Figure 3A) and decreased nighttime locomotor activity ( Figure 3B), as reported in the above-mentioned studies (Meerlo et al 1996;, were found on the actual days of exposure to social defeat and, to a lesser extent, after plus-maze exposure.…”

Section: Discussionsupporting

confidence: 83%

“…This finding indicates that rats from the LAB line, which have been shown to display a higher activity than HAB rats in an open field (Liebsch et al 1998), do not differ generally in their spontaneous home cage locomotor activity. This is in line with findings in the THE/TLE strains (Fujita et al 1994) and in Roman highand low-avoidance rats that also display differential activity in an open field (Gentsch et al 1981), but only a trend toward higher nighttime activity in high avoidance rats when measured telemetrically in the home cage (Meerlo et al 1997). It also supports the concept of "reactive" versus "spontaneous" locomotor activity (Courvoisier et al 1996;Gentsch et al 1991).…”

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confidence: 88%

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Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Liebsch

Linthorst

Neumann

et al. 1998

Neuropsychopharmacology

150

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Two Wistar rat lines, selectively bred for high-anxietyrelated behavior (HAB) and low-anxiety-related behavior (LAB) in the elevated plus-maze test, were tested for the susceptibility of their behavioral characteristics to anxiolytic treatment and for their endocrine and physiological reactivity to different stressors. Injection of 1mg/kg diazepam failed to affect line differences in coping strategy but resulted in a marked (20-fold) Genetic factors contribute to the high interindividual variability in type and/or intensity of the behavioral, neuroendocrine, and physiological stress responses observed in various species, including humans and laboratory rats (Boissy 1995;Clément et al. 1997;Cools et al. 1990;Curé and Rolinat 1992;Prasad et al. 1996;Spanagel et al. 1995;Tesser 1993;Zuckerman 1993). This fact has been used as the basis for selective bidirectional breeding programs from which strains and lines differing in their behavioral and/or neuroendocrine reFrom the Max Planck Institute of Psychiatry, Munich, Germany. Address correspondence to: Dr. R. Landgraf, Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany.Received January 15, 1997; revised March 25, 1998; accepted April 16, 1998. 382 G. Liebsch et al. N EUROPSYCHOPHARMACOLOGY 1998 -VOL . 19 , NO . 5 sponses to environmental challenges have emerged (Brush 1991;Castanon and Mormède 1994;Cools et al. 1993;Gentsch et al. 1988;Walker et al. 1992). Recently, we reported the establishment of two Wistar rat lines selectively bred for differing behavioral performances in the elevated plus-maze test, now termed high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) lines, respectively ). This animal model of inborn anxiety provides the advantage of avoiding conditioned stimuli that by themselves are likely to trigger behavioral, neuroendocrine, and physiological alterations. Interestingly, the HAB and LAB animals also prefer different coping strategies in a forced swim test ), pointing toward a link between anxiety and coping with stressful situations.The elevated plus-maze test is based on the creation of a conflict between the exploratory drive of a rat and its innate fear of open, exposed areas. It is one of the most widely used nonconditioned animal models of anxiety and has been extensively validated pharmacologically and ethologically (Dawson and Tricklebank 1995;Pellow 1986;Pich et al. 1993). However, various clinically effective anxiolytic substances often yield contradictory results when administered to "normal" unstressed rats in this test (Griebel 1995;Rodgers et al. 1997), indicating that-in parallel to the situation in humans (Green and Hodges 1991; Lader 1991)-the efficacy of an anxiolytic may depend upon the animal's basal level of anxiety. To test this prediction and to characterize further our breeding lines, in the first experiment, male rats from the HAB and LAB lines were injected with a classical anxiolytic, diazepam, and submitted to a plus-maze test and a forced swim test to assess the e...

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Section: Discussionsupporting

confidence: 83%

supporting

confidence: 88%

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Liebsch

Linthorst

Neumann

et al. 1998

Neuropsychopharmacology

150

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“…For example, Tsukuba [29], HAB/LAB [30] and Roman [63] animals did not exhibit any motor differences when measured under basal conditions in their home cage using a radiotelemetric system. Therefore, the motor effect observed in these genetic models of anxiety is not associated with general spontaneous locomotor activity but is a reaction to a possible threatening situation.…”

Section: Problem Of Locomotor Activitymentioning

confidence: 93%

Behavioral evaluation of eight rat lines selected for high and low anxiety-related responses

Gomes

Hassan

Maisonnette

et al. 2013

Behavioural Brain Research

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evaluation of eight rat lines selected for high and low anxiety-related responses" (2013 • Genetic models are powerful tools to help understand anxiety disorders.• In order to determine the extent to which multiple anxiety traits generalize we compared eight genetic lines of rats selected for single high or low emotional responses.• We find many behavioral traits generalize across different animal lines selected for a single trait. a b s t r a c t Anxiety traits can be stable and permanent characteristics of an individual across time that is less susceptible of influences by a particular situation. One way to study trait anxiety in an experimental context is through the use of rat lines, selected according to contrasting phenotypes of fear and anxiety. It is not clear whether the behavioral differences between two contrasting rat lines in one given anxiety test are also present in others paradigms of state anxiety. Here, we examine the extent to which multiple anxiety traits generalize across selected animal lines originally selected for a single anxiety trait. We review the behavioral results available in the literature of eight rat genetic models of trait anxiety -namely Maudsley Reactive and Non-reactive rats, Floripa H and L rats, Tsukuba High and Low Emotional rats, High and Low Anxiety-related rats, High and Low Ultrasonic Vocalization rats, Roman High and Low Avoidance rats, Syracuse High and Low Avoidance rats, and Carioca High and Low Conditioned Freezing rats -across 11 behavioral paradigms of innate anxiety or aversive learning frequently used in the experimental setting. We observed both convergence and divergence of behavioral responses in these selected lines across the 11 paradigms. We find that predisposition for specific anxiety traits will usually be generalized to other anxiety provoking stimuli. However this generalization is not observed across all genetic models indicating some unique trait and state interactions. Genetic models of enhanced-anxiety related responses are beginning to help define how anxiety can manifest differently depending on the underlying traits and the current environmentally induced state. a r t i c l e i n f o

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“…Yet, most of the work is restricted to mammals, in particular rodents and primates, exposed to severe or chronic stress procedures (e.g., prolonged social isolation, housing in overcrowded environments or early maternal separation) very unlikely to occur in the real world. An attempt to modify this approach has been made by testing the effect of social defeat in territorial animals, mainly rodents [11,14,15,17,19]. These studies clearly showed that this paradigm provides a powerful and realistic methodology to study strategies to cope with naturalistic stress [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of social defeat in a territorial bird (Parus major) selected for different coping styles

Carere

Welink

Drent

et al. 2001

Physiology & Behavior

168

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Effect of social defeat in a territorial bird (Parus major) selected for different coping styles Carere, C; Welink, D; Drent, Piet J.; Koolhaas, Jaap M.; Groothuis, Ton Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractWe addressed the questions (i) whether a social defeat triggers similar autonomic and behavioral responses in birds as is known from mammals and (ii) whether individuals that differ in coping style differ in their reaction to a social defeat. Adult captive male great tits (Parus major) from either of two different selection lines for coping style were used to test the effect of social defeat by an aggressive resident male conspecific on subsequent social and nonsocial behaviour, body temperature, breath rate and body mass. These parameters were measured 1 day before (baseline), immediately after and at Days 1 to 3 and 6 after the social interaction took place (Day 0). Social defeat decreased social exploration and increased body temperature substantially for at least 1 day in all birds. Breath rate and body mass were not affected. Birds belonging to the more aggressive and bolder line showed impairment in activity immediately after the social defeat. This is to our knowledge the first report showing that psychosocial stress in birds can have a similar impact as in rodents, but with a shorter recovery time. This might be due to species-specific differences in sensitivity to social stress, or to differences in the way social stress was induced. D

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Behavioural and physiological consequences of a single social defeat in Roman high- and low-avoidance rats

Cited by 95 publications

References 15 publications

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Behavioral evaluation of eight rat lines selected for high and low anxiety-related responses

Effect of social defeat in a territorial bird (Parus major) selected for different coping styles

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