Behavioural aspects and psychiatric findings in Noonan's syndrome.

Neuropsychological Functioning in Individuals with Noonan Syndrome: a Systematic Literature Review with Educational and Treatment Recommendations

“…In contrast to these findings, studies using standardized symptoms checklists have not found a significant difference in anxiety and depression symptoms in adults with NS compared with unaffected adults (Wingbermühle et al 2012a). Similarly, most studies have found no differences in parent-reported levels of depression/anxiety symptoms between children with NS compared with typically developing children (Pierpont et al 2015;Wood et al 1995;van der Burgt et al 1999), although Alfieri et al (2014) reported a 32 % rate of clinically elevated depression/anxiety symptoms in their sample of children with NS. In terms of self-concept, Lee et al (2005) administered the Piers-Harris Children's SelfConcept Scale (Piers and Harris 1989) to assess self-esteem in 30 children with NS.…”

“…Earlier studies using parent report measures such as the Child Behavior Checklist have noted children with NS showed greater difficulties related to attention and hyperactivity relative to comparison groups or normative data, although statistically significant differences were not always reported (van der Burgt et al 1999;Wood et al 1995;D. A. Lee et al 2005;Sarimski 2000;Alfieri et al 2014).…”

“…Aside from attention problems, another area in which clinically significant difficulties are consistently found on standardized behavioral checklists is social skills competence (Pierpont et al 2015;Alfieri et al 2014;Wood et al 1995;van der Burgt et al 1999). Individuals with NS have been described as having tendencies toward social immaturity, reduced interaction with peers, and diminished insight in social situations (Wingbermühle et al 2009;Sarimski 2000), although many of these characteristics have not been examined in depth.…”

A case of ADHD in a patient with Noonan syndrome

“…Wood et al have reported behavioural characteristics with non-specific psychiatric symptoms in 21 children with Noonan syndrome ranging from clumsiness, faddy eating, irritability and difficulty interpreting mood to excessive happiness. 8 In our case, the patient's behavioural profile responded well to stimulant medication. However, her management raised a number of challenges.…”

Características psicológicas en el síndrome de Noonan: a propósito de un caso

“…• Los niños con el Síndrome de Noonan pueden presentar múltiples alteraciones a nivel psicológico (7,8,9,10). Entre éstas, de modo específico con respecto a la valoración del CI, sería relevante estudiar más detenidamente las discrepancias entre aspectos verbales y manipulativos, así como entre subtests particulares.…”