Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; jaw movements

Koshikawa, Noriaki; Miwa, Yasuhiro; Adachi, Kazunori; Kobayashi, Masafumi; Cools, Alexander R.

doi:10.1016/0014-2999(96)00301-9

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…This conclusion fits in with earlier reports showing that this drug behave similarly to dopamine D2 receptor agonists (Caine et al, 1995;Freedman et al, 1994;Gonzalez and Sibley, 1995;Large and Stubbs, 1994;Liu et al, 1994;Starr and Stair, 1995). The present study, however, shows that this holds also true for intracerebrally administered 7-OH-DPAT, confirming and extending thereby the findings reported in our accompanying paper (Koshikawa et al, 1996b). Second, the dopamine-depen dent and shell-specific turning behaviour is just mediated by stimulation of dopamine D { and D 2 receptors.…”

Section: Discussionsupporting

confidence: 92%

“…Both the present study and the accompanying paper (Koshikawa et al, 1996b) provide direct evidence that the same holds true for 7-OH-DPAT when its cifect on shell-specific behaviours, such as turning behaviour and jaw movements, are studied. All these data together show that a thorough réévaluation of the dopamine D3 receptor specificity of 7-OH-DPAT is required.…”

Section: Discussionsupporting

confidence: 61%

“…The present study and the one reported in the accompa nying paper (Koshikawa et al" 1996b) intended to provide evidence that dopamine D3 receptors play a role in mediat ing functions of mesolimbic structures as has been sug gested before (Diaz et al, 1995;Sokoloff et al, 1990). For that purpose, we focused our attention on a brain structure in which these receptors are abundantly concentrated, viz.…”

Section: Discussionmentioning

confidence: 86%

“…Fax: 81 3 3219-8136. Freedman et al, 1994;Liu et al, 1994; behavioural stud ies: Koshikawa et al, 1996b;Large and Stubbs, 1994). Apart from the accompanying paper, in which the effects of intra-accumbens injections of 7-OH-DPAT on jaw movements were studied (Koshikawa et al, 1996b), all remaining studies on the behavioural function of dopamine D3 receptors are limited to studies in which 7-OH-DPAT and other putative, selective dopamine D3 receptor agents are systemically applied.…”

mentioning

confidence: 99%

“…Freedman et al, 1994;Liu et al, 1994; behavioural stud ies: Koshikawa et al, 1996b;Large and Stubbs, 1994). Apart from the accompanying paper, in which the effects of intra-accumbens injections of 7-OH-DPAT on jaw movements were studied (Koshikawa et al, 1996b), all remaining studies on the behavioural function of dopamine D3 receptors are limited to studies in which 7-OH-DPAT and other putative, selective dopamine D3 receptor agents are systemically applied. Dopamine D3 receptors are abun dantly concentrated in limbic structures, such as the nu cleus accumbens (Bouthenet et al, 1991;Levesque et al, 1992), and evidence has been presented that a subpopula tion of dopamine D3 receptors is located on neurons which serve as a major output route of the shell, but not the core, of the nucleus (Diaz et al, 1995).…”

mentioning

confidence: 99%

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Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; turning behaviour

Koshikawa

Kitamura

Kobayashi

et al. 1996

European Journal of Pharmacology

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The goal of this study was to determine whether the dopamine D3 receptor in limbic structures plays a role in the shell-specific and dopamine-dependent display of turning behaviour in rats. When combined with the dopamine receptor agonist (± )-i-phenyl-2,3,4,5-tetrahydro-1 //-3-benzazepine-7,8-diol (SKF-38393, 5 jx g ) , the putative dopamine D3 receptor agonist (±)-7-hydroxy-/V,N-di-n-propyl-2-aminotetralin (7-OH-DPAT, 1, 5 and 10 jJLg) elicited contralateral turning in a dose-dependent manner following unilateral injection into the shell, but not the core, of the nucleus accumbens. The turning pattern displayed was identical to that reported previously after intra-accumbens administration of the cocktail of SKF-38393 and the dopamine D2 receptor agonist quinpirole. The behaviour under study was dose-dependently attenuated by local administration of the dopamine Dj receptor antagonist /?(-h)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1//-3-benzazepi ne (SCH 23390: 10 and 100 ng), the dopamine D2 receptor antagonist domperidone (25 and 50 ng) or the dopamine D2/3 receptor antagonist /-sulpiride (5 and 25 ng). Combined blockade of both dopamine Dj and D2 receptors in the shell with a dose of either antagonist alone that produced just a moderate reduction (10 ng SCH 23390 and 50 ng domperidone) completely antagonized the turning behaviour elicited by the cocktail of SKF-38393 and 7-OH-DPAT. Replacing 7-OH-DPAT by another putative dopamine D3 receptor agonist, 5( + )-(4a/?,10W?)-3,4,4tf,10£~tetrahydro-4-propyl-2tf,5//-[l]benzopyrano [4,[3][4][5][6]907, 10 jxg), in the cocktail did produce no turning behaviour at all. It is concluded that mesolimbic dopamine D3 receptors play no role in the dopamine-dependent and shell-specific turning behaviour: the contribution of 7-OH-DPAT in the cocktail of SKF-38393 and 7-OH-DPAT to the display of turning behaviour is solely due to its ability to activate dopamine D2 receptors,

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; turning behaviour

Koshikawa

Kitamura

Kobayashi

et al. 1996

European Journal of Pharmacology

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Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior andc-fos mRNA expression in the brain

Semba

Tanaka

Wakuta

et al. 2001

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Heterogeneity of behavioural profile between three new putative selective D 3 dopamine receptor antagonists using an ethologically based approach

Clifford¹,

Waddington²

1998

Psychopharmacology

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The effects on behaviour of the putative selective D3 dopamine receptor antagonists GR 103691, nafadotride and U 99194A were compared with those of the generic D2-like antagonist haloperidol, using an ethologically based approach. Neither GR 103691 (0.008-1.0 mg/kg) nor nafadotride (0.025-1.6 mg/kg) influenced any element of behaviour. Conversely, U99194A (1.67-45 mg/kg) effected a dose-dependent stimulation of episodes of non-stereotyped sniffing, locomotion, chewing and eating, with some stimulation of rearing, and reduced baseline levels of grooming; thereafter, as sniffing and locomotion declined, stimulation of episodes of grooming emerged. Haloperidol (0.0008-0.1 mg/kg) failed to promote any element of behaviour and reduced baseline levels of grooming; responsivity to U99194A was antagonised by pretreatment with haloperidol. The lack of effect of GR 103691 (> 100-fold D3/D2 selectivity) and nafadotride (10-fold D3/D2 preference), in contrast to the characteristic "ethogram" for U99194A (25-fold D3/D2 selectivity), indicated a fundamental difference in their mechanisms of action. This topography of responsivity to U99194A overlapped somewhat with the profiles of both D2-like and D1-like agonists, and its sensitivity to antagonism by haloperidol also indicated a dopaminergic basis thereto. However, differences among GR 103691, nafadotride and U99194A bore no relation to their relative selectivities for the D3 receptor, and the basis thereof remains unclear. Theorising as to the behavioural role of the D3 receptor may need to be tempered pending the identification of a range of chemically distinct D3 antagonists of higher selectivity.

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Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; jaw movements

Cited by 15 publications

References 29 publications

Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; turning behaviour

Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; turning behaviour

Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior andc-fos mRNA expression in the brain

Heterogeneity of behavioural profile between three new putative selective D 3 dopamine receptor antagonists using an ethologically based approach

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