Behavioural effects of hypothalamic peptides

PrangeJr., Arthur J.; Nemeroff, Charles B.; Loosen, Peter T.

doi:10.1007/978-1-349-03668-4_7

Cited by 7 publications

(1 citation statement)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some, but not all. of our findings support the hypothesis that treatment with high doses of TRH reduce pituitarythyroid axis functions by a direct effect on hypophysial TRH receptors.Thyrotropin-releasing hormone (TRH) is a tripeptide (pGlu-His-Pro-NH2) which causes the release of thyro tropin (TSH) in vivo and in vitro [53], In addition to its function as a hypothalamic hypophysiotropic hormone, TRH appears to also influence behavioral and pharma cological processes in animals and man [37][38][39], For ex ample. TRH is a potent antagonist of barbiturate and ethanol-induced narcosis and hypothermia [5,35,36] and has also been reported to possess antidepressant properties [1,35] of TRH and a neurotropically active congener of the tri peptide (linear/(-alanine TRH; pGIu-His-Pro-/(-Ala-NH2), the possibility that some of the effects observed might be due to changes in thyroid status led us to examine the effects of chronic treatment with TRH or ft-ala TRH on serum concentrations of TSH, 1-triiodothyronine (T3) and thyroxine (T4).…”

mentioning

confidence: 99%

Effect of Chronic Treatment with Thyrotropin-Releasing Hormone (TRH) or an Analog of TRH (Linear <i>β</i>-Alanine TRH) on the Hypothalamic-Pituitary-Thyroid Axis

Nemeroff¹,

Bissette²,

Martin³

et al. 1980

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

The effects of treatment for 5 or 9 days with varying doses of thyrotropin-releasing hormone (TRH) or the linear β-alanine TRH congener (pGlu-His-Pro-β-Ala-NH₂) on serum levels of TSH, T₃ and T₄ were studied in mice and rats. At low doses in rats treatment with TRH for 9 days significantly increased serum levels of T₃ but not serum T₄ whereas a higher dose of TRH (10 mg/kg) reduced serum T₃ levels. β-ALA TRH (0.1–10 mg/kg IP) treatment for 9 days in rats significantly reduced serum T₄ levels whereas serum T₃ levels were only depressed at higher doses (1–10 mg/kg IP) of the peptide. In mice treatment for 5 days with TRH (1 and 10 mg/kg IP) significantly reduced serum levels of T₃ and T₄. In addition, TRH (0.1–10 mg/kg IP) or β-ALA·TRH treatment (1.0–10 mg/kg IP) for 9 days significantly reduced serum TSH levels in rats. TRH (10 mg/kg IP for 9 days) also significantly reduced serum GH levels in rats. No alteration in hypothalamic content of TRH or LHRH was observed after chronic TRH treatment. Some, but not all, of our findings support the hypothesis that treatment with high doses of TRH reduce pituitary-thyroid axis functions by a direct effect on hypophysial TRH receptors.

show abstract

mentioning

confidence: 99%

Effect of Chronic Treatment with Thyrotropin-Releasing Hormone (TRH) or an Analog of TRH (Linear <i>β</i>-Alanine TRH) on the Hypothalamic-Pituitary-Thyroid Axis

Nemeroff¹,

Bissette²,

Martin³

et al. 1980

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

Ontogeny of the neurotensin‐containing neuron system of the rat: Immunohistochemical analysis. I. Forebrain and diencephalon

Hara

Shiosaka

Senba

et al. 1982

J of Comparative Neurology

126

View full text Add to dashboard Cite

The ontogeny of the neurotensin (NT) neuron system in the forebrain and diencephalon of the rat was investigated by means of indirect immunofluorescence. NT-positive structures first appear in the primordium of the olfactory bulb, anterior amygdaloid area, piriform cortex, amygdaloid complex, nucleus tractus diagonalis, lateral preoptic area, and lateral hypothalamus, etc., of the fetus of gestational day 16. From this day, NT-positive structures appear gradually in various areas of the forebrain and diencephalon and reach their maximum content on postnatal day 7. In contrast, NT-positive structures decrease slightly in number as the rat grows. However, even in adult rats, numerous NT-positive structures are still identifiable in various areas of the forebrain and diencephalon.

show abstract

Other Peptide Receptors

Burt¹

1980

Neurotransmitter Receptors

View full text Add to dashboard Cite

Behavioural effects of hypothalamic peptides

Cited by 7 publications

References 105 publications

Effect of Chronic Treatment with Thyrotropin-Releasing Hormone (TRH) or an Analog of TRH (Linear <i>β</i>-Alanine TRH) on the Hypothalamic-Pituitary-Thyroid Axis

Effect of Chronic Treatment with Thyrotropin-Releasing Hormone (TRH) or an Analog of TRH (Linear <i>β</i>-Alanine TRH) on the Hypothalamic-Pituitary-Thyroid Axis

Ontogeny of the neurotensin‐containing neuron system of the rat: Immunohistochemical analysis. I. Forebrain and diencephalon

Other Peptide Receptors

Contact Info

Product

Resources

About