Given the considerable ongoing research interest in collaborative multidisciplinary modelling and co-simulation, it is worth considering the features of model-based techniques and tools that deliver benefits to cyber-physical systems developers. The European project "Integrated Tool Chain for Model-based Design of Cyber-Physical Systems" (INTO-CPS) has developed a well-founded tool chain for CPS design, based on the Functional Mock-up Interface standard, and supported by methodological guidance. The focus of the project has been on the delivery of a sound foundation, an open chain of compatible and usable tools, and a set of accessible guidelines that help users adapt the technology to their development needs.