Behcet's Disease and Endocrine System

Özhan, Onur; Sezer, Kerem

doi:10.1155/2012/827815

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…In Erdem et al's study, peripheral IR was assessed with hyperinsulinemic-euglycemic glucose clamp technique in patients with BD. Peripheral IR was found in patients with BD, and they postulated it might be related to inflammation and endothelial dysfunction [8,23]. Individuals with RAS have been shown to exhibit elevated levels of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Elevated insulin resistance in patients with recurrent aphthous stomatitis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Elevated insulin resistance in patients with recurrent aphthous stomatitis

et al. 2014

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“…Another mechanism may be that higher levels of RDW may reflect enhanced erythropoiesis resulting from circulating levels of neurohormonal mediators, which lead to an increase in the heterogeneity of circulating red cells. There is scant clinical data demostrating neurohormonal disorders in BD [29,30]. However, most of the publications on this regard are limited to case reports [30,31].…”

Section: Discussionmentioning

confidence: 99%

Association between Red Cell Distribution Width and Disease Activity in Patients with Behcet’s Disease

Aktürk¹,

Aktrk²,

Kurtoğlu³

et al. 2012

J Clin Exp Cardiolog

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Aims: we aimed to investigate whether red cell distribution width (RDW) can also be used for the assessment of disease activity in Behcet's disease (BD). Methods and results: Forty patients with active BD and seventy patients with inactive BD were included in the study. Forty-six healthy volunteers constituted the control group. Hematological parameters, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were analyzed by standard methods. All the individuals underwent comprehensive echocardiographic examination. Echocardiographic parameters of the study population were similar all groups. ESR, CRP and RDW were significantly higher in active BD patients than in inactive BD patients and controls (33.6±22 vs 15.7±9 vs 5±4.1, 23.4±21.6 vs 5.5±6.2 vs 1.2±0.5 and 17.2±2.5 vs 14.4±1.9 vs 13.2±0.5, p<0.0001 for all, respectively). Moreover, we also found that ESR, CRP and RDW were significantly higher in inactive BD patients when compared with the controls (15.7±9 vs 5±4.1, 5.5±6.2 vs 1.2±0.5 and 14.4±1.9 vs 13.2±0.5, p<0.0001 for all, respectively). There were modest positive correlations between RDW and disease duration (r=0.320, P=0.001). Conclusion: We demostrated that RDW significant increased in active and inactive BD patients without cardiac involvement. In addition, our study has established that RDW can be used to determine the disease activity state of BD.

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“…BD patients showed significant alterations in glucose, fructose, tagatose, xylose, myo-inositol, and threitol levels. Dysregulation of carbohydrates and sugar alcohols is associated with inflammation and insulin resistance in BD [ 25 , 26 ]. Increased levels of cytokines in BD, including tumor necrosis factor-alpha (TNF-α), interferon (IFN), and interleukin (IL)-1, have been shown to affect glucose homeostasis [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet’s disease

Park

et al. 2023

Arthritis Res Ther

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Background Behçet’s disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from patients with similar symptoms. Moreover, an authentic biomarker has not been developed for accurate diagnosis yet. Our current study investigated the unique metabolic signatures of BD and explored biomarkers for precise diagnosis based on an untargeted metabolomic approach. Methods Integrative metabolomic and lipidomic profiling was performed on plasma samples of BD patients (n = 40), healthy controls (HCs, n = 18), and disease controls (DCs, n = 17) using GC-TOF MS and LC-Orbitrap MS. Additionally, the lipid profiles of 66 peripheral blood mononuclear cells (PBMCs) were analyzed from 29 BD patients, 18 HCs, and 19 DCs. Results Plasma metabolic dysfunction in BD was determined in carbohydrate, hydroxy fatty acid, and polyunsaturated fatty acid metabolisms. A plasma biomarker panel with 13 compounds was constructed, which simultaneously distinguished BD from HC and DC (AUCs ranged from 0.810 to 0.966). Dysregulated PBMC metabolome was signatured by a significant elevation in lysophosphatidylcholines (LPCs) and ether-linked lysophosphatidylethanolamines (EtherLPEs). Ten PBMC-derived lipid composites showed good discrimination power (AUCs ranged from 0.900 to 0.973). Correlation analysis revealed a potential association between disease activity and the metabolites of plasma and PBMC, including sphingosine-1 phosphate and EtherLPE 18:2. Conclusions We identified metabolic biomarkers from plasma PBMC, which selectively discriminated BD from healthy control and patients with similar symptoms (recurrent mouth ulcers with/without genital ulcers). The strong correlation was determined between the BD activity and the lipid molecules. These findings may lead to the development for diagnostic and prognostic biomarkers based on a better understanding of the BD pathomechanism.

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Behcet's Disease and Endocrine System

Cited by 4 publications

References 16 publications

Elevated insulin resistance in patients with recurrent aphthous stomatitis

Elevated insulin resistance in patients with recurrent aphthous stomatitis

Association between Red Cell Distribution Width and Disease Activity in Patients with Behcet’s Disease

Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet’s disease

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