Behçet’s syndrome: clinical presentation and prevalence in Switzerland

Villiger, Rahel; Stefanski, Ana‐Luisa; Grobéty, Véronique; Adler, Sabine; Villiger, Peter M.

doi:10.4414/smw.2019.20072

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…4a) while only low seismicity is observed. This observation appears to be surprising although it is not the first time that extension was constrained across the Jura arc: the same conclusion was reached after mapping the strain field of Switzerland using 3D interpolation of strain rates on a regular grid 77 ; and after a joint processing of the AGNES/COGEAR datasets 78 . The extension is therefore not due to an artefact of network geometry or an interpolation issue.…”

Section: Resultsmentioning

confidence: 75%

Lithosphere strain rate and stress field orientations near the Alpine arc in Switzerland

Houlié

Woessner

Giardini

et al. 2018

Sci Rep

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In this study we test whether principal components of the strain rate and stress tensors align within Switzerland. We find that 1) Helvetic Nappes line (HNL) is the relevant tectonic boundary to define different domains of crustal stress/surface strain rates orientations and 2) orientations of T- axes (of moment tensor solutions) and long-term asthenosphere cumulative finite strain (from SKS shear wave splitting) are consistent at the scale of the Alpine arc in Switzerland. At a more local scale, we find that seismic activity and surface deformation are in agreement but in three regions (Basel, Swiss Jura and Ticino); possibly because of the low levels of deformation and/or seismicity. In the Basel area, deep seismicity exists while surface deformation is absent. In the Ticino and the Swiss Jura, where seismic activity is close to absent, surface deformation is detected at a level of ~2 10−8/yr (~6.3 10−16/s).

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Section: Resultsmentioning

confidence: 75%

Lithosphere strain rate and stress field orientations near the Alpine arc in Switzerland

Houlié

Woessner

Giardini

et al. 2018

Sci Rep

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“…Although contrary to other global reports with a low prevalence of disease, this finding may be supported by the awareness of BD among treating physicians in the region. For instance, an eight-year delay between symptom onset and the diagnosis was reported in Switzerland [17].…”

Section: Discussionmentioning

confidence: 99%

Behçet’s Disease in Saudi Arabia: Clinical and Demographic Characteristics

Alharthy¹,

Almaqati²,

Alsulami³

et al. 2023

Cureus

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This study aimed to analyze and determine the clinical features and characteristics of patients diagnosed with Behçet's disease (BD) in Saudi Arabia. MethodsThis single-center study was conducted in a tertiary care center in the western region of Saudi Arabia. Electronic medical records of patients with BD aged 14 years and older were reviewed and their demographic and clinical data were collected by trained rheumatologists. Between comparisons, Fisher's exact test, independent t-test, or Mann-Whitney U test was applied. The normality of variables was tested using the Kolmogorov-Smirnov and Shapiro-Wilk tests. ResultsThe mean age of symptom onset was 29.6 ± 11.4 years, and mean age at the time of diagnosis was 31.1 ± 11.9 years. Most patients were overweight (mean body mass index 26.7 ± 5.60 kg/m2). The most associated medical comorbidities were diabetes mellitus and hypertension. The most common clinical manifestations were oral ulcers (91.2%), genital ulcers (81.3%), arthritis (41.8%), and pseudofolliculitis (34.1%). Colchicine was the most prescribed treatment (95.6%), followed by prednisolone (72.5%), and azathioprine (36.3%). Male patients were significantly more likely to have pseudofolliculitis (p=0.011) and take a tumor necrosis factor alpha (TNF-α) inhibitor (p=0.045). Female patients were more likely to have neurological involvement (p=0.029). ConclusionAwareness of BD symptoms and early recognition can help provide timely and effective treatment to avoid disease complications.

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“…Furthermore, given the low prevalence of BS, most physicians in low prevalence countries are unfamiliar with the disease and its differentials: Studies in Germany, the Netherlands or Switzerland have demonstrated a diagnostic delay of up to 8 years from disease onset to time of diagnosis (17). In addition, clinicians falsely invoke fulfilment of the above-mentioned diagnostic/classification criteria as well as HLA-B51 positivity when establishing the diagnosis of BS (10).…”

Section: Introductionmentioning

confidence: 99%

When it looks like Behçet’s syndrome but is something else: differential diagnosis of Behçet’s syndrome: a two-centre retrospective analysis

et al. 2023

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Objective To investigate the differential diagnostic spectrum in patients with suspected Behçet’s syndrome (BS) in low prevalence regions. In addition, the number of patients fulfilling the ICBD criteria despite not having BS was evaluated. Methods This retrospective analysis was performed in two referral centers for BS. Patients with confirmed BS (clinical diagnosis with fulfilment of ISG criteria or a score of ≥ 5 points in the ICBD criteria) were excluded. The remaining patients were divided into eleven differential diagnosis categories. If no definitive alternative diagnosis could be established, patients were termed ‘probable BS’ in case of (1) relapsing orogenital aphthosis in the absence of other causes and either HLA-B51 positivity, origin from an endemic area or presence of an additional typical BS symptom that is not part of the classification criteria or (2) with 3–4 points scored in the ICBD criteria. Results In total 202 patients were included and categorized as follows: 58 patients (28.7%) as ‘probable BS’, 57 (28.2%) skin disease, 26 (12.9%) chronic pain syndrome, 14 (6.9%) eye disease, 11 (5.4%) spondyloarthropathy, 9 (4.5%) gastrointestinal disease, 7 (3.5%) neurological disease, 4 (2%) arthritis, 3 (1.5%) auto-inflammation, 3 (1.5%) connective tissue disease, 10 (5.0%) miscellaneous disease. HLA-B51 was positive in 55/132 (41.6%); 75/202 (37.1%) of the patients fulfilled the ICBD criteria. Conclusion In a low disease prevalence setting the straightforward application of the ICBD criteria may lead to overdiagnosis of BS. The differential diagnosis of BS is enormously broad. Clinicians should be aware that HLA-B51 positivity is still not considered as a diagnostic feature in BS.

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Behçet’s syndrome: clinical presentation and prevalence in Switzerland

Cited by 7 publications

References 19 publications

Lithosphere strain rate and stress field orientations near the Alpine arc in Switzerland

Lithosphere strain rate and stress field orientations near the Alpine arc in Switzerland

Behçet’s Disease in Saudi Arabia: Clinical and Demographic Characteristics

When it looks like Behçet’s syndrome but is something else: differential diagnosis of Behçet’s syndrome: a two-centre retrospective analysis

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