Beidseitige Zytomegalie-Retinitis bei einem Säugling mit letal verlaufenem konnatalen AIDS

Abstract

The authors report on a baby born on August 25, 1984 with a birthweight of 1100 g. Her parents used drugs intravenously and her mother had anti-HTLV III antibody. In the clinical course an immune deficiency syndrome with pathologic reduction of T4:T8 (T-helper: T-suppressor cells) was apparent. The child had no anti-HTLV III antibody, but exposition, typical clinical course and immunological data led to the diagnosis Acquired Immune Deficiency Syndrome (AIDS). In the 9th month bilateral progressive retinitis developed; it was thought to have been induced by cytomegalovirus. Complement-fixation antibody titer for cytomegalovirus was negative, but the virus was found in the urine. In the 12th month the baby died of cardiac arrhythmia caused by cytomegalic myocarditis. Macroscopic and light-microscopic illustrations of the inflammatory changes in both eyes are presented; in the retina there were large multinucleated cells which were visible macroscopically.

Report of a case of aggressive cytomegalovirus retinitis in an infant with AIDS

“…Only 15 cases of CMV retinitis in children with AIDS have been reported in the literature [13][14][15][16][17][18][19][20], 11 of them treated with ganciclovir and only 4 with foscarnet plus ganciclovir. In 1989, Dennehey [15], described the case of a 2-week-old infant with bilateral involvement of the retina, who died two weeks later despite treatment with ganciclovir.…”

Augenbeteiligung bei AIDS

“…Da AIDS in letzter Zeit auch bei Frauen und Kindern zunimmt, mull audi der Augenarzt haufiger an diese Moglichkeit denken. So wurde kurzlich uber eine CMV-Retinitis bei einem Saugling mit drogenabhangiger Mutter berichtet (8). Uber Pathogenese und Stellenwert des Mikroangiopathie-Syndroms herrscht noch nicht vollstandige Klarheit (10,13,15,24).…”

“…Uber Augenbeteiligung wurde seit 1982 berichtet, wobei die ersten und umfangreichen Publikationen aus den USA stammten. Später kamen Mitteilungen aus europaischen und einzelnen aul3ereuropäischen Landern hinzu (4,8,13,17,35).…”