Screening for Cytomegalovirus Retinitis in Children

Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency

“…Ophthalmologic examination in our patient revealed bilateral perivasculitis, active proliferative vitreoretinopathy formation, moderate vitritis, and dense pigmented white-black colored diffuse necrotizing retinitis that resemble chorioretinal scar formation involving all quadrants of the retina. The retinitis in congenitally infected newborns differs from that described in immunocompromised subjects, since it usually does not progress after birth if the child is otherwise immunocompetent [8]. In immunocompetent newborns with CMV retinitis, mild chorioretinal scarring to retinal necrosis like in our patient occurs in up to 20% of symptomatic neonates.…”

Active retinitis in an infant with postnatally acquired cytomegalovirus infection

“…5,6 However, even in immunocompromised children the occurrence of CMV retinitis after birth is very unusual, and only few cases have been reported. 7 Studies performed in humans and murine models suggest the role of the cell-mediated immune response in conditioning the MRI, magnetic resonance imaging; NBT, nitroblue tetrazolium test; Neut., neutrophils; PLT, platelets; US, ultrasound imaging; WBC, white blood cells.…”

CMV retinitis after cessation of ganciclovir therapy for CMV antigenemia in an unrelated BMT recipient

“…The main clinical manifestations of CMV disease after BMT are esophagitis, enteritis and interstitial pneumonia, 1 although CMV is known to infect many organs, including the liver, lung, digestive tract, brain, bone marrow and eye. 6 CMV retinitis affects as many as 40% of patients with AIDS. 2 However, a retrospective study suggested that the incidence of CMV retinitis in childhood BMT recipients is extremely low.…”