Beiträge zur Entwicklungsgeschichte der Gehörknöchelchen

Applications of electrochemistry in studies of the oxidation chemistry of central nervous system indoles

“…In addition, CVs of 32 exhibit reversible couples characteristic of dione 21s6 and p-quinone 30 residues.67 Attempts to concentrate even very dilute solutions of the purple dione 21 (e.g., by lyophilization) cause it to form the purple dimer 7,7'-bi(5-hydroxytryptamin-4-one) (33; Scheme VI). 68 This interesting compound can be reversibly reduced to 7,7/-bi(4,5-dihydroxytryptamine) (34) or reversibly oxidized to 7,7'-bi(tryptamine-4,5-dione) (35). Dione 21 also reacts directly with at least one simple dimer of 5-HT, i.e., 5,5'-dihydroxy-2,4/-bitryptamine (12), to give trimer 37 as shown in Scheme VII.…”

5,7‐Dihydroxytryptamine: improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine

“…IN A SERIES of morphological and biochemical investigations (BAUMGARTEN & LACHENMAYER, 1972;BAUMGARTEN et al, 1973a;BJORKLUND et al, 1973a;BAUMGARTEN et al, 1973b;JACOBY et al, 1974) 5,7-dihydroxytryptamine (5,7-DHT) has been shown to induce extensive axonal degeneration of central serotonin neurons after intraventricular or intracerebral injections in the rat. A major drawback of 5,7-DHT as a tool for chemical lesioning of serotonin meurons is, however, its poor discrimination between 5-HT and NA neurons, and thus both 5-HT and NA axons in the CNS are lesioned by the drug (BAUMGARTEN et al, 1973a;BJORKLUND et al, 1973a;JACOBY et al, 1974).…”