Beiträge zur Entwicklungsgeschichte des Säugethierherzens

Born, Guassenir Gonçalves

doi:10.1007/bf02956033

Cited by 64 publications

(13 citation statements)

References 2 publications

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“…In mammalian embryos, early descriptions of the pericardial villi near the sinus venosus were made by Lieberkühn [1876], Kölliker [1879], His [1881], Uskow [1883a, b] and Born [1889]. The presence of these villi in close proximity to the developing liver raised speculations on a possible contribution of the villi to the formation of hepatic blood vessels [for a review, see Uskow, 1883b].…”

Section: The Epicardial Primordiummentioning

confidence: 99%

The Origin, Formation and Developmental Significance of the Epicardium: A Review

Männer

Pérez‐Pomares

Macías

et al. 2001

Cells Tissues Organs

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Questions on the embryonic origin and developmental significance of the epicardium did not receive much recognition for more than a century. It was generally thought that the epicardium was derived from the outermost layer of the primitive myocardium of the early embryonic heart tube. During the past few years, however, there has been an increasing interest in the development of the epicardium. This was caused by a series of new embryological data. The first data showed that the epicardium did not derive from the primitive myocardium but from a primarily extracardiac primordium, called the proepicardial serosa. Subsequent data then suggested that the proepicardial serosa and the newly formed epicardium provided nearly all cellular elements of the subepicardial and intermyocardial connective tissue, and of the coronary vasculature. Recent data even suggest important modulatory roles of the epicardium and of other proepicardium-derived cells in the differentiation of the embryonic myocardium and cardiac conduction system. The present paper reviews our current knowledge on the origin and embryonic development of the epicardium.

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Section: The Epicardial Primordiummentioning

confidence: 99%

The Origin, Formation and Developmental Significance of the Epicardium: A Review

Männer

Pérez‐Pomares

Macías

et al. 2001

Cells Tissues Organs

288

250

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“…In a section of the reconstruction of the heart at this level, carried out according to Born's [1888] technique, we observe that the recess may be considered as the first indication of the division of the atrium commune; it presents one part on the left which is very dilated, the future left auricle, on the more ventral and lower part of which the common auriculoventricular canal opens out. The other part, the right one, will develop into the right auricle ( fig.…”

Section: Resultsmentioning

confidence: 99%

“…They were stained by different methods: HE, Brachet, Azan, and Bielschowsky (en bloc). Wax plate reconstructions were made by the method of Born [1888] of the hearts in stages 12. 13, H an d 17.…”

Section: Methodsmentioning

confidence: 99%

Origin and development of the septum primum

Fonollá¹,

Llorca²

1978

Cells Tissues Organs

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Based on the study often hearts of human embryos from the Orts Llorca collection in Madrid, comprising stages 12–17 of O’Rahilly, the origin ofthe septum primum was analyzed. The septum referred to has its origin in the dorsocaudal part of the common auricle starting from the cells of the lower cushion which makes contact with the wall of the auricle referred to. The closure of the atrioventricular canal is due to the introduction of the spina vestibuli of the septum primum between the two endocardial cushions. The foramen primum is formed in the human species in the same way as in the rest of the most highly developed vertebrates.

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“…It is a common view that the anlage of the common orifice of the pulmonary veins, the so‐called pulmonary pit, is a solitary unpaired structure. Matters of dispute, however, remain: first, the question as to whether the pulmonary pit arises either from the primitive embryonic atrium (Born, 1889; Neill, 1956; Van Praagh and Corsini, 1969; Goor and Lillehei, 1975; Los, 1978; Webb et al, 1998, 2000, 2001; Soufan et al, 2004; Anderson et al, 2006), as usually described in the textbooks, or from the sinus venosus (Fedorow, 1910; Brown, 1913; Buell, 1922; DeRuiter et al, 1995; Tasaka et al, 1996; Blom et al, 2001), and, second, the question as to whether the pulmonary pit originally has a midline identity (Brown, 1913; Auër, 1948; Van Praagh and Corsini, 1969; Webb et al, 1998; Wessels et al, 2000; Jongbloed et al, 2004) or a left‐sided identity (Born, 1889; Neill, 1956; Goor and Lillehei, 1975; Los, 1978; Tasaka et al, 1996). In this context, some researchers have presented data that cast doubt on the existence of the sinus venosus as a discrete segment of the heart tube in higher vertebrate embryos.…”

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confidence: 99%

Early morphogenesis of the sinuatrial region of the chick heart: A contribution to the understanding of the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages

Männer

Merkel

2007

The Anatomical Record

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The morphogenesis of the sinuatrial region of embryonic hearts is still not well understood. Current matters of dispute are the topogenesis of the future pulmonary vein orifice and the topogenesis of the primary atrial septum. We analyzed the development of the sinuatrial region in chick embryos ranging from Hamburger and Hamilton (HH) stage 14 to 25. Our study disclosed three features of sinuatrial development. First, the primitive atrium of the HH stage 16 chick embryo heart has a separate inflow component. This inflow component takes up the mouth of the confluence of the systemic veins (sinus venosus) as well as the future mouth of the common pulmonary vein (pulmonary pit). The left portion of the atrial inflow component becomes incorporated into the left atrium and its right portion becomes incorporated into the right atrium. Rightward growth of the sinuatrial fold separates the sinus venosus from the left atrium. Second, the pulmonary pit originally forms as a bilaterally paired structure. Its left and right portions are connected to the left and right portions of the atrial inflow component, respectively. Normally, only the left portion of the pulmonary pit deepens to form the common pulmonary vein orifice, whereas the right portion disappears. Third, the primary atrial septum of the chick heart is not formed at the original midline of the embryonic heart, but is formed to the left of the original midline. This finding is in accord with molecular data suggesting that the primary atrial septum derives from the left heart-forming field. Our findings shed new light on the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages. Anat

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Beiträge zur Entwicklungsgeschichte des Säugethierherzens

Cited by 64 publications

References 2 publications

The Origin, Formation and Developmental Significance of the Epicardium: A Review

The Origin, Formation and Developmental Significance of the Epicardium: A Review

Origin and development of the septum primum

Early morphogenesis of the sinuatrial region of the chick heart: A contribution to the understanding of the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages

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