Beiträge zur Physiologie und Pathologie der Verdauung

Ewald, C. A.; Boas, J. W. S. Vilas

doi:10.1007/bf01994707

Cited by 22 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1886, Ewald and Boas (1) noted that addition of olive oil to a test meal of gruel depressed acid secretion in human subjects. Workers in Pavlov's laboratory demonstrated that this phenomenon could only be demonstrated if fat was allowed to pass beyond the stomach (2).…”

Section: Introductionmentioning

confidence: 99%

Enterogastrone-like effect of peptide YY is vagally mediated in the dog.

Pappas¹,

Debas²,

Taylor³

1986

J. Clin. Invest.

View full text Add to dashboard Cite

Intraluminal fat inhibits gastric secretion through as yet undetermined mechanisms which involve release of one or more hormonal enterogastrones. As intraluminal fat releases Peptide YY (PYY) in amounts sufficient to inhibit meal-stimulated acid secretion, this ileo-colonic peptide exhibits the characteristics required of an enterogastrone. The present study seeks to determine the mechanism by which PYY inhibits acid secretion by examining the effects of PYY on gastric acid stimulated by pentagastrin, histamine, and bethanechol. In addition, effects of PYY on the acid response to sham feeding and distention of a denervated gastric pouch were examined. A dose of PYY (400 pmols kg-' * h-') was employed that reproduced blood levels observed after intestinal perfusion with oleic acid and inhibited the acid secretory response to an intragastric meal by 35±6%. This same dose of PYY maximally inhibited histamine-and pentagastrin-stimulated acid secretion by 28±7% (P < 0.05), and 17±4% (P < 0.05), respectively. Although PYY had no effect on bethanechol-stimulated secretion it markedly inhibited the secretory response to sham feeding, maximally reducing secretion by 90±4% (P < 0.01). We speculate that PYY acts by inhibiting acetylcholine release from vagal nerve fibers rather than by inhibiting acetylcholine's action on the parietal cell. The demonstration that PYY virtually abolishes cephalic phase acid secretion while having little if any effect on the response to exogenous secretogogues gives PYY unique characteristics among the known hormonal inhibitors of gastric secretion.

show abstract

Section: Introductionmentioning

confidence: 99%