Barriers to mental health care exist at an individual level (e.g., perceptions of mental health problems and treatment, perceived access), a provider level (e.g., knowledge, attitude, behaviors), and a systems level (e.g., appointment availability, facilities, medical record access).The provision of mental health treatment is also affected by the strength, health, and wellbeing of the health care workforce. Health care provider burnout-defined as chronic occupational-related stress, emotional exhaustion, disengagement, depersonalization, anhedonia, and hopelessness-poses a critical threat to mental and behavioral health care for service members, veterans, and their families.This report presents a series of literature reviews related to burnout. The objectives are to synthesize key concepts, models, and applications of burnout; assess the magnitude of burnout among U.S.-based providers, including among U.S. military health care providers; understand risk factors for burnout among health care providers; and assess interventions to mitigate and/or prevent burnout across professions, including those directed toward military health care providers. Evidence syntheses are a key component in the knowledge translation process and they function to translate the available research into evidence-based health care guidelines that promote optimal clinical care.