Benchmark dose in the presence of coexposure to melamine and diethylhexyl phthalate and urinary renal injury markers in pregnant women

Chen, Chu-Chih; Wang, Yin-Han; Hsieh, Chia‐Jung; Wang, Shuli; Chen, Mei-Lien; Tsai, Hung-Chin; Li, Sih-Syuan; Liu, Chia-Chu; Tsai, Yi‐Chun; Hsieh, Tusty‐Jiuan; Wu, Ming-Tsang

doi:10.1016/j.envres.2022.114187

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…A cohort study targeting third trimester of pregnant women in Taiwan showed that the urine phthalate concentration was positively correlated with ACR and N-acetyl-β-D-glucosaminidas (NAG) (Tsai et al, 2021). Another study enrolling 1236 pregnant women showed that co-exposure to phthalate and melamine will higher increase NAG and ACR, compared with exposure to either substance alone (Chen et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Especially in the late stage of pregnancy, when the pregnant woman is approaching delivery, maintaining normal renal function is important to maintain the body's homeostasis, which is crucial for the health of the mother and infant. However, to our best knowledge, there are only two studies about the in uence of phthalate on the renal function of pregnant women: One study found that exposure to phthalate increases the markers of early renal damage: microalbumin and N-Acetyl-β-D-Glucan (NAG) during the last trimester of pregnancy (Tsai et al, 2021); Other one reported that it is more likely to cause an increase in early renal injury indicators when pregnant women are exposed to both phthalates and melamine at the same time (Chen et al, 2022). Although microalbumin and NAG can show the presence of renal injury, to our knowledge, early renal injury markers are not included in the routine examination of pregnant women's pregnancy examinations in southwestern China.…”

Section: Introductionmentioning

confidence: 99%

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Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Hong,

Pu,

et al. 2023

Preprint

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Background Phthalates exposure associates with increased serum uric acid levels in the general population, and whether this association also exists in pregnant women has not been explored yet. Methods we conducted a cross-sectional population-based study including 851 pregnant women from a ZunYi birth cohort in southwestern China. Multiple linear regression models were used to explore single relationship between ten urinary phthalate metabolites with SUA and eGFR. Moreover, the overall relationship of ten urinary phthalate metabolites with SUA and eGFR were determined by principal component analysis (PCA) and quantitative g-computation (Q-g) analysis, respectively. Besides, the potential effect modification factors were explored by employing the subgroup analysis. Results The multivariable linear regression showed that MBP, MOP and MBzP were positively associated with SUA, while MEHP and MEHHP were associated with increased eGFR level. Moreover, mixed phthalate metabolites were positively associated with SUA, evidence by PCA analysis, of which MOP, MBzP and MEHP exhibited the major contributors. Furthermore, Q-g regression showed each quantile increase in mixture of phthalate was associated with 3.27% higher SUA (95% CI: 0.21%, 6.41%), but not significant with eGFR. Conclusion pregnant women’s exposure to phthalates was associated with a higher serum uric acid, in which MBP, MBzP and MOP might play important roles. Our results imply that positive perinatal health should be seriously taken to counteract the environment-associated impaired kidney function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Hong,

Pu,

et al. 2023

Preprint

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“…Human studies : Recent studies have shown that phthalates can affect kidney function in children, pregnant women, and adults [ 3 , 148 , 189 , 190 , 191 , 192 ]. Phthalates have a strong relationship with the urinary albumin creatinine ratio (ACR) and eGFR in children with CKD.…”

Section: Phthalatesmentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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“…Melamine was among the first substances suggested as a PMT/vPvM substance , and, therefore, has recently been identified as a substance of very high concern (SVHC) under the European Union’s Chemicals Regulation, REACH. , Melamine has previously made headlines worldwide due to its unauthorized addition to pet food and infant formula, which led to severe adverse health impacts on animals and young children . Epidemiological studies further show that it is closely associated with kidney damage and reproductive interference, − and it may have low toxicity to algae, fish, shrimp, and other aquatic organisms. , …”

Section: Introductionmentioning

confidence: 99%

“…15 , 16 Melamine has previously made headlines worldwide due to its unauthorized addition to pet food and infant formula, which led to severe adverse health impacts on animals and young children. 17 Epidemiological studies further show that it is closely associated with kidney damage and reproductive interference, 18 − 20 and it may have low toxicity to algae, fish, shrimp, and other aquatic organisms. 21 , 22 …”

Section: Introductionmentioning

confidence: 99%

Dynamic Source Distribution and Emission Inventory of a Persistent, Mobile, and Toxic (PMT) Substance, Melamine, in China

Zhang,

Chen,

Wang

et al. 2023

Environ. Sci. Technol.

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Persistent, mobile, and toxic (PMT) substances are affecting the safety of drinking water and are threatening the environment and human health. Many PMT substances are used in industrial processing or consumer products, but their sources and emissions mostly remain unclear. This study presents a long-term source distribution and emission estimation of melamine, a high-production-volume PMT substance of emerging global concern. The results indicate that in China, approximately 1858.7 kilotonnes (kt) of melamine were released into the water (∼58.9%), air (∼27.0%), and soil systems (∼14.1%) between 1995 and 2020, mainly from its production and use in the decorative panels, textiles, and paper industries. The textile and paper industries have the highest emission-to-consumption ratios, with more than 90% emissions per unit consumption. Sewage treatment plants are the largest source of melamine in the environment for the time being, but in-use products and their wastes will serve as significant melamine sources in the future. The study prompts priority action to control the risk of PMT substances internationally.

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Benchmark dose in the presence of coexposure to melamine and diethylhexyl phthalate and urinary renal injury markers in pregnant women

Cited by 10 publications

References 56 publications

Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Dynamic Source Distribution and Emission Inventory of a Persistent, Mobile, and Toxic (PMT) Substance, Melamine, in China

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