“…Patients with severe disease present a cytokine storm in the blood that may include elevation of TNF-α, CCL2, CXCL10 (IP-10), MCP-1, MIP-1α, GCSF, IL-1β, IL-2, IL-6, IL-7, IL-8, IL-10, and IL-17 [2][3][4][5][6][7][8][9]. A recent study using machine learning/artificial intelligence approaches in plasma proteomics datasets of COVID-19 patients linked severe disease with B cell dysfunction, increased inflammation, activation of Toll-like receptors, and decreased activation of developmental and immune mechanisms such as SCF/c-Kit signaling [10]. The proteins identified by artificial intelligence with the highest predictive values for COVID-19 disease severity were the following: CRK-like proto-oncogene, adaptor protein (CRKL), interleukin 1 receptor-associated kinase 1 (IRAK1), NF-kappa-B essential modulator/inhibitor of nuclear factor kappa-B kinase subunit gamma (NEMO/IKBKG), axis inhibition protein 1 (AXIN1), serine/arginine-rich protein-specific kinase 2 (SRPK2), and the cytoplasmic histidine-TRNA ligase (HARS1) [10].…”