Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

Mohammadghasemi, Fahimeh; Abbasi, Masumeh; Rudkhaneei, Kamran; Aghajany-Nasab, Monireh

doi:10.1111/and.13065

Cited by 8 publications

(6 citation statements)

References 41 publications

(57 reference statements)

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“…Unlike our result, a number of studies showed a high level of sperm abnormal morphology in diabetes, as compared to the control group (Ghorbanlou et al, 2020; Mohammadghasemi et al, 2018). In addition, Tsao et al (2015) demonstrated negative significant correlation between sperm morphology and concentration with body adiposity in a 7630 male population (Tsao et al, 2015).…”

Section: Discussioncontrasting

confidence: 99%

“…It is also of note that aforementioned anomalies are reported to be higher in the prediabetic state as compared to the diabetic state, based on the fact that in the diabetic state, an adaptation is achieved and animal or individuals has been able to partially overcome the inflammatory stage unlike in pre-diabetic state (Akbarian et al, 2021;Nevin et al, 2018;Portela et al, 2015). Unlike our result, a number of studies showed a high level of sperm abnormal morphology in diabetes, as compared to the control group (Ghorbanlou et al, 2020;Mohammadghasemi et al, 2018). In addition, Tsao et al (2015) demonstrated negative significant correlation between sperm morphology and concentration with body adiposity in a 7630 male population (Tsao et al, 2015).…”

Section: Discussioncontrasting

confidence: 63%

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The effect of green coffee and/or endurance exercise on sperm function in pre‐diabetic mice

et al. 2022

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This study aimed to investigate the effect of green coffee (GC), chlorogenic acid (CA) as an active ingredient of GC and exercise, alone or in a combination with exercise, on spermatogenesis and sperm function in pre‐diabetic mice. Results revealed that pre‐diabetic status can have a significant adverse effect on spermatogenesis (Johnson score), and sperm concentration, motility, DNA damage and persistent histone in compared to the control group. Although lipid peroxidation, intracellular ROS production, and persistent histones in sperm were high in pre‐diabetic mice, exercise only can improve sperm motility. GC alone only improved sperm motility in pre‐diabetic mice while CA alone, even did not have this beneficial effect. However, GC along with exercise, did not improve motility but reduce DNA damage, while CA with exercise, significantly improved motility compared to pre‐diabetic stage and to the level comparable to control. Therefore, based on this result in individuals with high DNA damage, GC supplementation and exercise could be useful approach while in asthenozoospermia, CA supplementation and exercise should be considered as an alternative approach. However, such an interpretation awaits validation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 63%

The effect of green coffee and/or endurance exercise on sperm function in pre‐diabetic mice

et al. 2022

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“…Steatosis was considered moderate if it was in the range of 33% to 66%. Finally, if it exceeded 66%, it was called severe [ 16 ]. Inflammatory cells were counted in representative lobules and expressed as a percentage for histological investigation of the liver.…”

Section: Methodsmentioning

confidence: 99%

“…Apple vinegar also improves spermatogenesis testicular function by reducing HOMA-IR, Lee index, apoptosis of germ cells, and increasing total antioxidants in a rat model of NAFLD [ 16 ]. Little is known about NAFLD and female reproductive function.…”

Section: Introductionmentioning

confidence: 99%

Effect of apple vinegar on folliculogenesis and ovarian kisspeptin in a high-fat diet-induced nonalcoholic fatty liver disease in rat

et al. 2022

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Background Non-alcoholic fatty liver disease (NAFLD) adversely affects reproduction. We aimed to study the effect of a high-fat diet (HFD), supplemented with apple vinegar, on folliculogenesis in a rat model of NAFLD. Methods Female rats were randomly divided into four groups (N = 28): Standard diet (SD), SD + vinegar, HFD, and HFD + vinegar groups. At the end of the study, biochemical tests were assessed in serum. HOMA-IR (Homeostatic model assessment-Insulin resistance) was calculated. Sex hormones were determined using an ELISA kit; ovary follicle counts were studied using histological methods. The proliferation index of granulosa cells was determined using immunohistochemistry. Kisspeptin expression in the ovary was detected using RT-PCR. Results The HFD induced steatohepatitis and NAFLD. The ovaries in the rat model of NAFLD were atrophied. The ovaries had less count of developing follicles and corpus luteum, and more degenerated and cystic follicles in comparison with the SD group. Vinegar + HFD consumption decreased ALT, compared to the HFD group (P = 0.004). Steatohepatitis was reduced in the Vinegar + HFD group (P = 0.001). Vinegar + HFD considerably reduced HOMA-IR (p = 0.01). The HFD + vinegar diet could increase estradiol (P = 0.001), without significantly affecting progesterone or testosterone. In addition, an increase of primordial follicles as an ovarian reserve and also primary follicles were determined in the HFD + vinegar group. There were no statistical differences in the granulosa cell proliferation index in various follicle types between groups. HFD + vinegar significantly enhanced ovarian kisspeptin expression (p = 0.04). Conclusions The vinegar diet in a rat model of NAFLD raises estradiol, primordial, and small primary follicles, and increases ovarian kisspeptin expression indirectly. Insulin resistance and obesity were improved by apple vinegar, and anti-glycemic and anti-lipidemic effects were also determined. The supplementation of apple vinegar in NAFLD might be useful for ovary. However, it requires further investigation.

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“…The Homeostatic Model of Assessing Insulin Resistance (HOMA-IR) was determined based on the flowing formula: HOMA-IR=Insulin×Glucose/22.5 [20].…”

Section: The Homeostatic Model Of Assessing Insulin Resistancementioning

confidence: 99%

The Extract of Viola odorata Flowers Improves the Biochemical, Pancreas Histological, and Insulin Resistance Parameters in an Animal Model of Diabetes

Gazor

Niknezhad

Yousefbeyk

et al. 2022

IJT

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Background: The antioxidant defense in the pancreas is low because they are exposed to toxic substances daily. This study aimed to evaluate the ameliorating effect of Viola odorata flowers Extract (VOE) on the pancreas histology and function in Streptozotocin (STZ)-induced diabetic rats. Methods: Forty male rats were divided into five groups, consisting of controls; STZ; and STZ plus various doses of VOE (100, 200 or 400 mg/kg). The amylase, lipase, insulin and total antioxidant capacity levels were measured in the sera. The homeostatic model assessment of insulin resistance was also measured. The histopathological alterations of the rats’ pancreases were examined microscopically. Results: The serum amylase and total antioxidant activities were reduced in diabetic rats (P=0.001). Varying doses of VOE reduced the serum amylase and glucose levels, and increased the total antioxidant activities compared to that of the diabetic rats (P<0.05). There were no significant differences in the serum lipase and insulin levels among the groups. Treatment with VOE at all doses significantly lowered the insulin resistance compared to that of the diabetic group (P=0.001). Significant reductions were observed in the areas of the pancreatic Langerhans islets and the number of beta cells in the STZ group (P=0.001). Conclusion: This study demonstrated that VOE ameliorated the adverse effects induced by STZ in the rat’s pancreas in the short-term. These effects are likely to be due to the reduced insulin resistance and amylase activity, and increased total antioxidant activity along with the histopathological alterations in the pancreas.

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Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

Cited by 8 publications

References 41 publications

The effect of green coffee and/or endurance exercise on sperm function in pre‐diabetic mice

The effect of green coffee and/or endurance exercise on sperm function in pre‐diabetic mice

Effect of apple vinegar on folliculogenesis and ovarian kisspeptin in a high-fat diet-induced nonalcoholic fatty liver disease in rat

The Extract of Viola odorata Flowers Improves the Biochemical, Pancreas Histological, and Insulin Resistance Parameters in an Animal Model of Diabetes

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