Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programs

Liu, Xuhan; Li, Guosheng; Zhu, Hua; Huang, Lan; Liu, Yali; Ma, Chi; Qin, Chuan

doi:10.1507/endocrj.k10e-043

Cited by 54 publications

(31 citation statements)

References 23 publications

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“…It has been historically used as an anti-diarrheal, anti-protozoal, and antimicrobial agent in Ayurvedic and Chinese medicine. It also possesses multitude of biological effects, including antiinflammatory, antidiabetic, lipid peroxidation, and neuroprotective activity (Liu et al, 2009;Lee et al, 2010;Wu et al, 2010;Zhou et al, 2010;Zhao et al, 2011). However, quaternary amine cation of BER causes poor water solubility, resulting in low bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Sailor¹,

Seth²,

Parmar³

et al. 2015

J App Pharm Sci

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The present study demonstrates the application of 3 2 full factorial design for optimization of berberine loaded liposome for oral administration. Thin film hydration method was used to prepare liposome and optimization was done by 3 2 full factorial designs combined with desirability function. Nine formulations were prepared by using different drug : lipid and soyphosphatidylcholine : cholesterol (SPC:CHOL) ratios and evaluated for entrapment efficiency and vesicle size. The statistical validity of model was done by analysis of variance (ANOVA). Response surface graph and contour plots were used to understand the effect of variables on responses. The optimized formulation with 0.782 desirability value was prepared and evaluated for responses. The results of entrapment efficiency and vesicle size were found to be very close with the predicted values. In addition, an optimized formulation was also characterized for zeta potential, in vitro drug release and morphology. The formulation was found to be spherical shape with an average diameter of 0.823 nm and -1.93 mV zeta potential and also shows sustained release pattern. These results support the fact that 3 2 full factorial designs with desirability function could be effectively used in optimization of berberine loaded liposome.

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Section: Introductionmentioning

confidence: 99%

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Sailor¹,

Seth²,

Parmar³

et al. 2015

J App Pharm Sci

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show abstract

“…In this paper, the authors verified that the berberineinduced alterations of hepatic LXR , without involvement of LXR , transcriptional programs contribute to decrease the blood glucose and lipid levels thus preventing the progress of obesity-related diabetes [272].…”

Section: Liver X Receptor (Lxr): Functions and Natural Ligandsmentioning

confidence: 64%

Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications

D’Auria¹,

Sepe²,

Zampella

2012

CTMC

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Nuclear receptors are key regulators of various processes including reproduction, development, and metabolism of xeno- and endobiotics. Research in the last two decades has focused to the development of novel drugs specifically targeting nuclear receptors for the treatment of a variety of diseases, such as cancer, diabetes, dyslipidemia, fatty liver disease, drug hepatotoxicity and cholestasis. The search for novel NRs agonists and antagonists with enhanced selectivity prompted the exploration of the extraordinary chemical diversity associated to natural products. In recent years a number of natural products were disclosed as ligands of NRs and proved to have remarkable affinity and in some cases peculiar mode of action. In this review the natural ligands of the subfamily NR1, NR2, and NR3 will be described with an emphasis to their mechanisms of action and pharmacological profiles.

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“…Coptisine, which is used as gastric mucosa protector, and berberine, which has very interesting properties as antiinflamatory, antidiabetes, antidiarrhea, and hypocholesterolemic drug, have been obtained from this plant. Both of them have also shown antitumoral activities in in vitro models [87][88][89][90][91][92].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

et al. 2011

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Abstract:In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)-a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr) cells, while Evodia lepta, Hedyotis Moreover, among fifteen water extracts that combined high antiproliferative activity (IC 50 0.5-20 µg/mL) and low acute in vitro toxicity (0-10% reduction in cell viability at IC 50 ), Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

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Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programs

Cited by 54 publications

References 23 publications

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs

Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

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