Beneficial Effect of Caffeic Acid on Alcohol-Induced Alterations in Lipid Peroxidation and Antioxidant Defense in Rats

Abstract

We studied the effect of caffeic acid on alcohol-induced oxidative stress in alcohol-induced toxicity in rats. The elevation in the levels of lipid peroxidation in alcohol administration was accompanied by a significant decrease in the levels of vitamins C and E, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and glutathione S-transferase (GST) in the liver and kidney. Oral administration of caffeic acid at a dose of 12 mg/kg/body weight for 45 days significantly reduced the severe oxidative stress in alcohol toxicity as evidenced by the decrease in the levels of lipid peroxidation with a simultaneous increase in the level of enzymic and nonenzymic antioxidants in liver and kidney. Histological studies in the liver and kidney also showed that administration of caffeic acid to alcohol-treated rats resulted in a marked reduction in alcohol-induced pathological changes. These results suggest that administration of caffeic acid to alcohol-supplemented rats alleviates the alcohol-induced oxidative damage in the liver and kidney.

Caffeic acid alleviates the increased lipid levels of serum and tissues in alcohol‐induced rats

“…In conclusion, our study suggests that oral administration of CA to alcohol fed rats markedly reduced the accumulation of cholesterol, TG, FFA and PL in circulation, liver and kidney. hepatic biomarkers, lipid peroxidation products and increased the antioxidant defense in alcohol-induced hepatotoxicity in rats [21,22].…”

“…hepatic biomarkers, lipid peroxidation products and increased the antioxidant defense in alcohol-induced hepatotoxicity in rats [21,22]. The objective of this study was to determine the effect of caffeic acid (CA) on alcohol-induced alterations of lipid levels in serum, liver and kindey of Wistar rats.…”

Caffeic acid improves cell viability and protects against DNA damage: involvement of reactive oxygen species and extracellular signal-regulated kinase

“…It has biological and pharmacological properties that include antiviral, antioxidant, anti-inflammatory, anticarcinogenic, and immunomodulatory activity (1-5). Extensive evidence from both in vitro and in vivo studies suggests that CaA is an important antioxidant and has health benefits (2,4). CaA can inhibit lipoxygenase activity and suppress lipid peroxidation (2).…”

“…Extensive evidence from both in vitro and in vivo studies suggests that CaA is an important antioxidant and has health benefits (2,4). CaA can inhibit lipoxygenase activity and suppress lipid peroxidation (2). Moreover, CaA alleviates alcohol-induced oxidative damage in the liver and kidney (6).…”

The Cytoprotective Effects of Hydroxycinnamic Acid are Mediated by Its Antioxidant Activity

“…4,5 CaA has been demonstrated to modulate cellular responses to oxidative stress. 8 A recent study showed that CaA acts as a strong antioxidant by increasing levels of reduced glutathione (GSH) and the activity of the detoxification enzyme GPx, protects DNA content, and preserves tissue histopathology in methamphetaminetreated mice. 6 In addition, CaA inhibits lipid peroxidation and exerts a DNA-protective effect in normal human peripheral blood mononuclear cells exposed to H 2 O 2 -induced oxidative stress 7 and alcohol-induced oxidative damage in rats.…”