Beneficial effect of
            <i>Amorphophallus paeoniifolius</i>
            tuber on experimental ulcerative colitis in rats

Dey, Yadu Nandan; Sharma, Garima; Wanjari, Manish; Kumar, Dharmendra; Lomash, Vinay; Jadhav, Ankush

doi:10.1080/13880209.2016.1226904

Cited by 30 publications

(14 citation statements)

References 51 publications

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“…In the current study, intrarectal administration of 3% acetic acid caused induction of UC, and there was marked decrease in BW of animals in colitis group in agreement with the results of the previous studies [1,17]. The BW reduction of animals is indicative of their weakened state due to colitis.…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Biochemical, histopathological and histochemical effects of Vitis vinifera L extract on acetic acid-induced colitis.

Hasona¹,

Hussien²

2017

J Intercult Ethnopharmacol

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Section: Discussionsupporting

confidence: 80%

“…IBD is a chronic disease that can involve gastrointestinal system. IBD remains a major gastrointestinal health-care issue [1]. The prevalence of IBD has been increasing, and higher incidence rates of IBD are seen in the developed countries [2].…”

Section: Introductionmentioning

confidence: 99%

Biochemical, histopathological and histochemical effects of Vitis vinifera L extract on acetic acid-induced colitis.

Hasona¹,

Hussien²

2017

J Intercult Ethnopharmacol

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“…β-Sitosterol has been applied in treating many diseases because of the anti-inflammatory, anti-proliferative and anticancer effects (17,18). However, the effect of BAMBI together with β-sitosterol on cell autophagy and proliferation in NSCLC is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway

Wang

et al. 2017

Oncology Reports

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Abstract. Non-small cell lung cancer (NSCLC) has the highest mortality rate among all solid tumors with a poor prognosis. The BMP and activin receptor membrane bound inhibitor (BAMBI) has been identified as a hallmark of NSCLC and β-sitosterol possesses antitumor potentiality. This study explores the effect of BAMBI overexpression and β-sitosterol in the context of NSCLC. The results revealed that the transfection of pcDNA-BAMBI and β-sitosterol treatment significantly reduced the levels of autophagy markers light chain 3 (LC3) II and Beclin 1, whereas the levels of LC3 I and p62 were promoted. The reduced punctate accumulations of GFP-LC3 were detected in pcDNA-BAMBI and β-sitosterol groups, especially in pcDNA-BAMBI + β-sitosterol group. BAMBI overexpression and β-sitosterol induced G0/G1 cell cycle arrest and inhibted cell proliferation in A549 cells. In addition, the levels of transforming growth factor-β (TGF-β)/p-Smad2/3/c-Myc pathway proteins were decreased. The TGF-β overexpression further confirmed that BAMBI overexpression and β-sitosterol treatment suppre ssed autohagy and viability of A549 cells was through TGF-β/Smad2/3/c-Myc pathway. Finally, the tumor growth was suppressed in NSCLC xenografts, and the inhibitory effect was stronger under treatment of pcDNA-BAMBI together with β-sitosterol. These results indicate that BAMBI overexpression and β-sitosterol may serve as novel targets for the treatment of NSCLC. IntroductionLung cancer is the leading cause of deaths with the most rapidly increasing incidence worldwide. Non-small cell lung cancer (NSCLC) has the highest mortality rate among all solid tumors with a poor prognosis (1). More than half of lung carcinomas are detected in a progressed or already metastasized state with a 5-year survival, for lacking of characteristic early symptoms (2). The general therapy treating the majority of patients is chemotherapy, which often induces resistance (3). It is necessary to develop novel therapeutic approaches to better understand the lung cancer progression.Autophagy is a fundamental cellular homeostatic process that cells use to degrade and recycle cellular proteins (4). This process can be induced in response to either intracellular or extracellular factors, such as hypoxia, low cellular energy state and organelle damage (5). The microtubule-associated protein 1 light chain 3 (LC3), functions as a structural component in the formation of autophagosomes. The conversion of the cytosolic form of LC3 (LC3 I) to lipidated form (LC3 II) indicates autophagosome formation (6). Beclin 1, is required for the initiation and in the process of autophagosome formation (7). p62 acts as a receptor or adaptor for autophagic degradation of ubiquitinated proteins, the upregulation of p62 is commonly detected in human tumors and contributes dire ctly to tumorigenesis (8). Thus, LC3, Beclin 1 and p62 were considered as autophagy markers in many studies (9,10).Transforming growth factor-β (TGF-β) has a crucial role in homeostasis, fibrosis angiogenesis, carcinogenesis and d...

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“…The content of glucomannan in the tuber extracts was also high (Dey et al, 2016). Further, we isolated betulinic acid and β-sitosterol from the tuber extract by column chromatography (Dey et al, 2017a), however, they were identified based on thin layer chromatography. Hence, the present study was conducted to characterize the isolated compounds of A. paeoniifolius tuber extracts and to investigate the effect of tuber extract and its constituents (glucomannan and betulinic acid) on experimental constipation on loperamide-induced constipation in rats and its modulation by standard laxative agent.…”

Section: Introductionmentioning

confidence: 90%

Beneficial effect of standardized extracts of Amorphophallus paeoniifolius tuber and its active constituents on experimental constipation in rats

Dey

Wanjari

Srivastava

et al. 2020

Heliyon

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The tubers of Amorphophallus paeoniifolius (Elephant foot yam), principally consumed as crop food and vegetables, are used in ethno-medicinal practices in mitigation of constipation and piles. Hence, present study evaluated the effect of tubers of A. paeoniifolius and its active constituents glucomannan and betulinic acid on experimentallyinduced constipation. The tuber and its extracts were standardized as per Ayurvedic Pharmacopoeia of India and physicochemical constants were found within the pharmacopoeial limit. HPTLC fingerprint profile of extracts has been developed using suitable mobile phase. Methanolic extract was subjected to column chromatography. The isolated phytoconstituents were characterized by FT-IR, NMR and MS and identified as betulinic acid and β-sitosterol. Functional constipation was induced in rats by oral administration of loperamide (3 mg/kg) for first 3 consecutive days. The rats were orally treated with methanolic and aqueous tuber extracts in the doses of 125, 250 and 500 mg/kg, glucomannan (300 mg/kg) and betulinic acid (1.5 mg/kg) for 7 days. The parameters viz. number of stools, wet weight of stools and moisture content of stools and intestinal transit were studied. Treatment with tuber extracts, glucomannan and betulinic acid showed significant (p < 0.05) increase in fecal parameters and intestinal transit in constipated rats. The effects were comparable to standard laxative drug, sodium picosulfate (5 mg/kg, orally). The results indicated that tuber extracts and its active constituents showed laxative effect and relieved constipation. It is concluded that tuber of A. paeoniifolius exhibited beneficial effect in functional constipation possibly through its laxative action. The study validates its ethno-medicinal use in correction of constipation. The principal constituents, betulinic acid and glucomannan in tuber extracts might have played important role in relieving the constipation.

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Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Cited by 30 publications

References 51 publications

Biochemical, histopathological and histochemical effects of Vitis vinifera L extract on acetic acid-induced colitis.

Biochemical, histopathological and histochemical effects of Vitis vinifera L extract on acetic acid-induced colitis.

BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway

Beneficial effect of standardized extracts of Amorphophallus paeoniifolius tuber and its active constituents on experimental constipation in rats

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