Beneficial effect of olanzapine in schizophrenic patients with obsessive-compulsive symptoms

Poyurovsky, Michael; Dorfman-Etrog, Pnina; Hermesh, Haggai; Munitz, Hanan; Tollefson, Gary D.; Weizman, Abraham

doi:10.1097/00004850-200015030-00006

Cited by 41 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The weak D2 receptor-blocking properties of clozapine may be also accounted for the onset of OCD-like symptoms [3]. Temporary OCS is associated with the dose of clozapine reported in the literature [4]. A total of 55 patients are included in 30 reports between 1990 and 2002, focusing on atypical antipsychotic treatment-induced OCS or exacerbation of preexisting OCS in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

et al. 2013

View full text Add to dashboard Cite

ObjectivePatients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.MethodIn this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.ResultsAll four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.ConclusionThis case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.

show abstract

Section: Introductionmentioning

confidence: 99%

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The prevalence of OCD in the general population remains quite controversial ; however, it is certainly much lower (with estimates from 0.08 to 2.5 % ; e.g. Fireman et al 2001 ;Crino et al 2005) than the prevalence of OCD in schizophrenia, which has estimates ranging from 0.5 to 59.2 % both in firstepisode and in chronic schizophrenia (Bland et al 1987 ;Karno et al 1988 ;Berman et al 1995 ;Eisen et al 1997 ;Poyurovsky et al 1999aPoyurovsky et al , 2000Poyurovsky et al , 2003Poyurovsky et al , 2006Bermanzohn et al 2000 ;Kruger et al 2000 ;Niehaus et al 2005 ;Mukhopadhaya et al 2009) and for OCS in schizophrenia the estimated prevalence is similarly between 3.5 and 46 % (Rosen, 1957 ;Myers et al 1984 ;Fenton & McGlashan, 1986 ;Berman et al 1995Berman et al , 1998Lysaker et al 2000 ;Tibbo et al 2000 ;Fabisch et al 2001). It remains unclear if this reflects a true comorbidity, more severe illness or perhaps a unique diagnostic subcategory of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

View full text Add to dashboard Cite

Background. Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neurocircuitry.Method. We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness.Results. The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than statemarker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion.Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.

show abstract

“…Current neuropsychopharmacological approaches seek to outline the determinants of substance usage, including the neurobiological roots of etiology and the interactive complications of substance abuse in schizophrenia and other neuropsychiatric disorders (Addington and Addington, 1998;George et al, 2000;Herran et al, 2000;Haustein et al, 2002;Peterson et al, 2002;Spring et al, 2003;Els, 2004). These observations and the therapeutic efficacy of atypical antipsychotic agents, e.g., olanzapine, f suggest neuropathophysiological convergence of OCD and psychoses (Poyurovsky et al, 2000). Substance abuse disorders occur commonly in schizophrenic patients showing increases in violence, hospitalisation, treatment non-compliance and overall deterioration in prognosis.…”

Section: Introductionmentioning

confidence: 98%

Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders

et al. 2007

View full text Add to dashboard Cite

Psychiatric disorders may co-occur in the same individual. These include, for example, substance abuse or obsessive-compulsive disorder with schizophrenia, and movement disorders or epilepsy with affective dysfunctional states. Medications may produce iatrogenic effects, for example cognitive impairments that co-occur with the residual symptoms of the primary disorder being treated. The observation of comorbid disorders in some cases may reflect diagnostic overlap. Impulsivity, impulsiveness or impulsive behaviour is implicated in a range of diagnostic conditions including substance abuse, affective disorder and obsessive-compulsive disorder. These observations suggest a need to re-evaluate established diagnostic criteria and disorder definitions, focusing instead on symptoms and symptom-profiles.

show abstract

Beneficial effect of olanzapine in schizophrenic patients with obsessive-compulsive symptoms

Cited by 41 publications

References 0 publications

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders

Contact Info

Product

Resources

About