Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats

Kaur, Navneet; Jamwal, Sumit; Deshmukh, Rahul; Gauttam, Vinod; Kumar, Puneet

doi:10.1016/j.toxrep.2015.08.004

Cited by 29 publications

(17 citation statements)

References 42 publications

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“…Such increase may be due to the association of this substance with increased mitochondrial energy metabolism that is probably responsible for the high rate of oxidative metabolic activity in the brain which gives rise to intense production of reactive oxygen metabolite and subsequently to the generation of free radicals implicated in the pathogenesis of neurological disorders. These results may have relation with the reports of Kumar et al [ 24 ] and Kaur et al [ 25 ], which suggest that 3-NPA depleted GSH in cortex, although the present study was made with young animal models.…”

Section: Discussionsupporting

confidence: 86%

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

et al. 2018

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BackgroundNeurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca2+ concentrations and the formation of reactive oxygen species. The presence of these free radicals may also affect the dopaminergic system. The aim of this work was to determine if riboflavin (B2) and pyridoxine (B6) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers.MethodsMale Fisher rats were grouped (n = 6) and treated as follows: group 1, control (NaCl 0.9%); group 2, 3-NPA (20 mg/kg); group 3, B2 (10 mg/kg); group 4, B2 (10 mg/kg) + 3-NPA (20 mg/kg); group 5, B6 (10 mg/kg) and group 6, B6 + 3-NPA. All treatments were administered every 24 h for 5 days by intraperitoneal route. After sacrifice, the brain was obtained to measure DA, GSH, and lipid peroxidation, Ca2+, Mg2+, ATPase and H2O2.Main findingsLevels of dopamine increased in cortex, striatum and cerebellum/medulla oblongata of animals that received 3-NPA alone. The lipid peroxidation increased in cortex, striatum, and cerebellum/medulla oblongata, of animals treated with B2 vitamin alone. ATPase dependent on Ca+2, Mg+2 and H2O2 increased in all regions of animals that received 3-NPA alone.ConclusionThe results confirm the capacity of 3-NPA to generate oxidative stress. Besides, the study suggests that B2 or B6 vitamins restored the levels of DA and reduced oxidative stress in brain of rats. We believe that these results would help in the study of neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 86%

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

et al. 2018

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“…In current study, LPS induction diminished the neurotransmitters level in the LPS induced brain as compared to normal control group. The findings justified the previous observations that showed the severe depletion of DA levels in experimental animals on LPS administration (Kaur, Jamwal, Deshmukh, Gauttam, & Kumar, ). Previous findings also suggested that in neurological disorders, the biphasic deviations can occur in dopamine neurotransmission wherein the DA neurotransmission level increased in the early phase and led to hyperkinesia, and in later phase DA level reduced to cause hypokinesia (Cepeda, Murphy, Parent, & Levine, ).…”

Section: Discussionsupporting

confidence: 92%

“…It was supported by others. Reports showed that rice bran hexane extract normalizes the level of neurotransmitters, the protection is because of the presence of phytonutrients, γ‐oryzanol, tocopherols, and tocotrienols (Kaur et al, ). The variation in response against LPS could be because varying levels of phytonutrients present in each variety and the tendency of each component against oxidative stress and neurochemical changes (Kaur et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Reports showed that rice bran hexane extract normalizes the level of neurotransmitters, the protection is because of the presence of phytonutrients, γ‐oryzanol, tocopherols, and tocotrienols (Kaur et al, ). The variation in response against LPS could be because varying levels of phytonutrients present in each variety and the tendency of each component against oxidative stress and neurochemical changes (Kaur et al, ). Research has shown that the oral supplementation of flavonoid rich antidepressant extract rich improved the level of serotonin, DA and NE in rat brain against external stimuli (Calapai et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non-pigmented rice bran extracts

Yadav

Appukuttan

2018

J Food Biochem

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This study evaluated the neuroprotective efficacy of the pigmented and non‐pigmented rice bran extract, against LPS induced neurotransmitter imbalance and oxidative stress markers. Male wistar rats were orally supplemented with 2% ethanolic rice bran extracts daily for two weeks. On the last day of experiment, rats were challenged intraperitoneally (i.p) with LPS for 4 hr. LPS exposure resulted in the elevation of malondialdehyde and nitrite levels, decreased GSH, increased antioxidant enzymes activity and led to imbalance in neurotransmitters, norepinephrine, dopamine and serotonin and their metabolites 3,4‐dihydroxyphenylacetic acid, homovanillic levels and acetylcholinesterase activity. Pre‐treatment with rice bran extracts significantly attenuated LPS induced oxidative stress by improving the antioxidant systems, acetylcholinesterase activity and neurotransmitters imbalance with the higher potency for pigmented bran extracts. The findings suggest the possibility of utilization of pigmented bran extract for the prevention of neurodegenerative diseases and promote the overall good health of the brain. Practical application Present study provides the current evidence for the neuroprotective efficacy of bran extracts from pigmented and non‐pigmented rice. These findings indicate the beneficial effects of pre‐treatment of rice bran extracts on LPS induced oxidative stress and neurochemical imbalance by improvement in the antioxidant machinery and neurotransmitters level. This study emphasizes the possibility of utilization of pigmented bran extract as a food ingredient to improve the overall brain health.

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“…Followed by complex II inhibition 3-NP makes mitochondrial dysfunction by in uencing mitochondrial dynamics and organelle tra cking, results in bioenergetic failure. Mitochondrial dysfunction is the most prominent feature of movement disorders like Huntington's Chorea, developed in response to 3-NP induced impairment in mitochondrial Ca 2+ handling, transcription abnormalities, ATP production, electron transport chain (ETC) impairment (Brouillet, 2014;Kaur et al, 2015). (Fig 1.1) From the last two-decade large number of therapeutic candidate has been proposed as a treatment strategy for movement disorders, especially for TD & HD but there inappropriate pharmacokinetic and toxicity pro le hampers their protective effect.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid & Haloperidol Induced Neurotoxicity in Rats

Rahi¹,

Ram²,

Kumar³

2021

Preprint

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Movement disorders are the heterogeneous group of disorders characterized by the progressive and selective impairment in motor function. Movement disorders like Huntington's disease (HD) and Tardive dyskinesia (TD) share many common features at both cellular and subcellular levels. Filgrastim is a recombinant methionyl granulocyte colony-stimulating factor (GCSF), shows neuroprotective properties in in-vivo models of movement disorders. The present study was designed to evaluate the neuroprotective effect of filgrastimin the animal models of haloperidol and 3-NP induced neurotoxicity in rats. Study was divided in two different protocol, in study one, rats were administered with haloperidol for 21 days, and filgrastim at the dose of (20, 40 & 60 µg/kg,s.c.) was administered once a day, before haloperidol treatment and the following parameters (orofacial movements, rotarod, actophotometer) were assessed for TD. Similarly, in second study rats were administered with 3-NP for 21 days and filgrastimat the dose of (20 & 40 µg/kg, s.c.) was administered, and following parameters (rotarod, narrow beam walk and open field test) were assessed for HD. In each study, on 22nd day, animals were sacrificed, to isolate cortex and striatum for oxidative stress (LPO, GSH, SOD, catalase, and nitrate) parameters. The result revealed that haloperidol and 3-NP treatment significantly impaired motor coordination, oxidative defense and induce TD and HD like symptoms. Filgrastim pre-treatment significantly averted haloperidol & 3-NP induced behavioral and biochemical alterations, respectively. Conclusively, neuroprotective effect of filgrastim is credited to its antioxidant properties, hence filgrastim might be a novel therapeutic candidate to manage TD & HD.

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Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats

Abstract: Graphical abstract

Cited by 29 publications

References 42 publications

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non-pigmented rice bran extracts

Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid & Haloperidol Induced Neurotoxicity in Rats

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Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats

Abstract: Graphical abstract

Cited by 29 publications

References 42 publications

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non-pigmented rice bran extracts

Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid &amp; Haloperidol Induced Neurotoxicity in Rats

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Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid & Haloperidol Induced Neurotoxicity in Rats