Beneficial effects of acarbose in the atherosclerosis-prone JCR: LA-corpulent rat

Pharmacology of Glucosidase Inhibitors

“…An improved glucose tolerance was also reported when glucose was injected intraperitoneally (TuLP et al 1988;AXEN 1993) or intravenously (RuSSEL et al 1993a). An explanation may be that a peripheral insulin insensitivity of these hyperinsulinaemic animals was ameliorated due to an improved metabolic control as a consequence of treatment with glucosidase inhibitors.…”

“…Basal glucose concentrations of hyperinsulinaemic rats, diabetic rats and mice were significantly ameliorated by acarbose (FOELLMER et al 1993;FRIEDMAN et al 1991;PETERSON et al 1993;. No effect of acarbose on basal blood glucose was reported by other authors (COHEN 1993;FRIED et al 1993;MAGGIO et al 1993;RUSSEL et al 1993a;VASSELLI et al 1993). In the latter experiments, blood sampies were collected from rats after a very short time period of food withdrawal (3 h only) or with the an im als under halothane anaesthesia.…”

“…A low dose of miglitol did not improve the lipid profile of lean, obese and obese diabetic rats (TuLP et al 1991b). Acarbose failed to affect plasma triglycerides during a 38-week treatment of genetically diabetic mice with non-insulin-dependent diabetes mellitus (NIDDM) (FOELLMER et al 1993) and JCR: LA-cp rats (RuSSEL et al 1993a), although the total plasma cholesterol and cholesterylesters were significantly reduced in acarbose-treated rats.…”

Animal models for the atherosclerosis research: a review

“…Thus, hyperlipidemia and atherogenesis may only be induced in rats by high cholesterol/high fat diets containing cholic acid and thiouracil (Joris et al, 1983). Several strains of rats with heritable hyperlipidemia, and some of those associated with atherogenesis, have been described (St. John and Bell, 1991;Russell et al, 1993;Chinellato et al, 1994). Thus far, however, few transgenic rats (e.g., those overexpressing human CETP in a DS hypertensive strain) have been shown to produce atherosclerosis (Herrera et al, 1999).…”

Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR: LA‐corpulent rats treated with d‐fenfluramine

“…The hyperlipidaemia is mainly caused by high concentrations of very low density lipoprotein (VLDL) caused by the oversecretion of this lipoprotein which is more pronounced in the females (Russell et al, 1989a;Vance & Russell, 1990). The corpulent male rats spontaneously develop both atherosclerotic and myocardial lesions.…”