Beneficial effects of Camelina sativa oil on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a mice model of irritable bowel syndrome

Cojocariu, Roxana; Balmus, Ioana Miruna; Lefter, Radu; Hrițcu, Luminiţa Diana; Ababei, Dana; Ciobîcă, Alin; Copaci, Simona; Copolovici, Lucian; Copolovici, Dana; Jurcoane, Ştefana

doi:10.25083/rbl/25.3/1532.1540

Cited by 8 publications

(9 citation statements)

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“…The ethanolic and methanolic extracts of defatted C. sativa seeds were shown to reverse short-term memory impairment and reduce anxiety and depression-like behaviors in a Swiss mouse model for irritable bowel syndrome exposed to various stress tests [ 289 ]. Furthermore, these extracts decreased superoxide dismutase, but increased glutathione peroxidase activity in brain and bowel tissues as well as potentially increasing lipid peroxidation in the bowel.…”

Section: Uses Of C Sativamentioning

confidence: 99%

“…Furthermore, these extracts decreased superoxide dismutase, but increased glutathione peroxidase activity in brain and bowel tissues as well as potentially increasing lipid peroxidation in the bowel. The authors concluded that seed extracts could improve performance and mood while exhibiting antioxidant capacity in both brain and bowel tissues [ 289 ]. In a related study, the administration of cold-pressed C. sativa oil was shown to ameliorate impairment of short-term memory, anxiety, and depression in a Swiss mouse zymosan-induced model for irritable bowel syndrome exposed to various stress tests [ 290 ].…”

Section: Uses Of C Sativamentioning

confidence: 99%

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Realizing the Potential of Camelina sativa as a Bioenergy Crop for a Changing Global Climate

Neupane

Lohaus

Solomon

et al. 2022

Plants

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Camelina sativa (L.) Crantz. is an annual oilseed crop within the Brassicaceae family. C. sativa has been grown since as early as 4000 BCE. In recent years, C. sativa received increased attention as a climate-resilient oilseed, seed meal, and biofuel (biodiesel and renewable or green diesel) crop. This renewed interest is reflected in the rapid rise in the number of peer-reviewed publications (>2300) containing “camelina” from 1997 to 2021. An overview of the origins of this ancient crop and its genetic diversity and its yield potential under hot and dry growing conditions is provided. The major biotic barriers that limit C. sativa production are summarized, including weed control, insect pests, and fungal, bacterial, and viral pathogens. Ecosystem services provided by C. sativa are also discussed. The profiles of seed oil and fatty acid composition and the many uses of seed meal and oil are discussed, including food, fodder, fuel, industrial, and medical benefits. Lastly, we outline strategies for improving this important and versatile crop to enhance its production globally in the face of a rapidly changing climate using molecular breeding, rhizosphere microbiota, genetic engineering, and genome editing approaches.

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Section: Uses Of C Sativamentioning

confidence: 99%

Section: Uses Of C Sativamentioning

confidence: 99%

Realizing the Potential of Camelina sativa as a Bioenergy Crop for a Changing Global Climate

Neupane

Lohaus

Solomon

et al. 2022

Plants

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“…The authors found that CSO intervention caused a significant reduction in MDA levels, as well as increases in SOD and GHP-x levels. 45 The effect of CSO on OS has been examined only in one clinical trial and reported no remarkable changes in urinary prostanoids in patients with IGM. 22 Han et al found that FSO consumption led to a significant reduction in MDA levels and a significant increase of GSH and SOD in mice.…”

Section: Discussionmentioning

confidence: 99%

Camelina oil in the context of a weight loss programs improves glucose homeostasis, inflammation and oxidative stress in NAFLD patients: A randomized, triple -blind, placebo-controlled clinical trial

Musazadeh

Dehghan

salehghadimi

et al. 2021

Preprint

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Background: Over the past few years, the benefits of co-administration of omega-3 and antioxidants have been reported in the management of non-alcoholic fatty liver disease (NAFLD) complications.This study evaluated the effects of Camelina sativa oil (CSO) supplementation as one of the richest dietary sources of omega-3 fatty acids on glucose homeostasis,inflammation, metabolic endotoxemia, and oxidative stress in NAFLD patients. Methods: In all, 43 subjects with NAFLD were allocated to either an intervention (20g/d CSO) or placebo (20g/d sunflower oil) group receiving a calorie-restricted diet for 12 weeks. Fasting serum levels of glycemic indices, hs-CRP, endotoxin, antioxidant enzymes activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8-iso-prostaglandin F2α (8-iso-PGF2α), and uric acid were measured at baseline and post-intervention. Results: CSO intake led to a significant decrease in insulin concentration (-17.49%), homeostasis model assessment of insulin resistance (HOMA-IR) (-20%), high-sensitive C-reactive protein (hs-CRP), (-12.94%), lipopolysaccharide endotoxin (-32.55%), malondialdehyde (MDA) (-18.75%), 8-iso-prostaglandin F2α (8-iso-PGF2α) (-19.55%) and a significant increase in the levels of total antioxidant capacity (TAC) (31.82%) and superoxide dismutase activity (10.22%) in the CSO group compared with the placebo group. Also, there was no significant difference between the two groups in fasting plasma glucose, quantitative insulin sensitivity check index (QUICKI), catalase, glutathione peroxidase activity, and uric acid level. In addition, within-group analyses showed a significant reduction of insulin, QUICKI, hs-CRP, and endotoxin levels in the intervention group. Conclusion: These findings indicate that CSO may improve glycemic, inflammation, metabolic endotoxima, oxidative stress status, and mental health in patients with NAFLD.

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“…Madalina defatted seeds harvested in Romania. Also, we previously reported the effect of the Camelina sativa oil obtained from seeds harvested in the same year on the behavioural manifestations and oxidative stress parameters in another mouse model of irritable bowel syndrome [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Camelina sativa is a flowering plant in the Brassicaceae family, native to northern Europe and central Asia, traditionally cultivated as an oilseed biofuel crop to produce vegetable oil and animal feed [ 28 , 29 ]. The oil extracted from seeds is rich in linolenic acid (C18:3 ω 3, ALA), an essential ω 3 fatty acid ( ω 3FA), whose consumption has been associated with a decreased risk of coronary heart disease and inflammatory diseases [ 30 – 38 ] and some beneficial effects on behavioural manifestations and oxidative stress parameters in a zymosan-induced IBS mouse model [ 39 ]. Most of the therapeutical properties of the Camelina sativa seeds are due to phenolic content, such as sinapine and phytic acid [ 40 ], antioxidants (tocopherols) [ 29 ], flavanols (quercetin) [ 41 ], and glucosinolates [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Camelina sativa Methanolic and Ethanolic Extract Potential in Alleviating Oxidative Stress, Memory Deficits, and Affective Impairments in Stress Exposure-Based Irritable Bowel Syndrome Mouse Models

Cojocariu

Balmuș

Lefter

et al. 2020

Oxidative Medicine and Cellular Longevity

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Camelina sativa is mainly used as an oilseed crop; its edible oil is being also used as a traditional home remedy for the treatment of ulcers, wounds, and eye inflammations, due to the antioxidant activities. In the present study, the chemically characterized alcoholic extracts of Camelina sativa var. Madalina defatted seeds (5 g/kg body weight p.o., suspended in CMC-Na 0.1%) were administered to stress-induced animal models of irritable bowel syndrome (based on combinations of contention stress and multifactorial stress and maternal stress) and evaluated for the behavioural (short-term memory by the Y maze test, the anxious behaviour using the elevated plus maze test, and the antidepressant effect using the forced swimming test) and brain and bowel tissue oxidative status (superoxide dismutase and glutathione peroxidase enzymes activities and malondialdehyde and total soluble protein levels) improving effects. According to the chemical characterization, the extracts were rich in sinapine, glucosinolates, and flavonol glycosides. Moreover, this study showed the beneficial effects of Camelina sativa seed methanolic and ethanolic extracts on the behaviour and brain and bowel tissues oxidative stress status of stress exposure-based IBS mouse models. Despite the slight differences in the chemical composition of the methanolic and ethanolic extracts, the results suggested that the Camelina sativa extracts could reverse the short-term memory impairments caused by stress exposure and also could decrease the intensity and frequency of the anxiety and depressive-like behaviours observed in the stress-exposed animal models of IBS. Furthermore, the Camelina sativa extracts showed a significant effect on the oxidative stress markers in the brain and bowel tissues of the studied animal model by decreasing the superoxide dismutase activity and increasing the glutathione peroxidase activity. However, the results suggested that the extracts could also increase lipid peroxidation in bowel tissues. In this way, this study provides additional evidence that the administration of Camelina sativa seed alcoholic extracts could improve cognitive performances and mood and exhibit the antioxidant capacity in both the brain and bowel tissues.

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Beneficial effects of Camelina sativa oil on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a mice model of irritable bowel syndrome

Cited by 8 publications

References 0 publications

Realizing the Potential of Camelina sativa as a Bioenergy Crop for a Changing Global Climate

Realizing the Potential of Camelina sativa as a Bioenergy Crop for a Changing Global Climate

Camelina oil in the context of a weight loss programs improves glucose homeostasis, inflammation and oxidative stress in NAFLD patients: A randomized, triple -blind, placebo-controlled clinical trial

Camelina sativa Methanolic and Ethanolic Extract Potential in Alleviating Oxidative Stress, Memory Deficits, and Affective Impairments in Stress Exposure-Based Irritable Bowel Syndrome Mouse Models

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