Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats

Vardı, Nigar; Parlakpınar, Hakan; Ateş, Burhan

doi:10.1016/j.jchemneu.2011.09.003

Cited by 37 publications

(30 citation statements)

References 33 publications

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“…The protective SOD efficiency of the ZML extract and the polyphenol was on the same order with that of the CAT protective efficiency. The protective SOD efficiency is consistent with a previous study (Vardi, Parlakpinar, & Ates, 2012), indicating the SOD activity in the chlorogenic acid and methotrexate group was 1.75-fold compared to that of methotrexate group and was 3.60 U/mg protein higher than that of the control group.…”

Section: 5supporting

confidence: 91%

Effects of pepper (Zanthoxylum bungeanum Maxim.) leaf extract on the antioxidant enzyme activities of salted silver carp (Hypophthalmichthys molitrix) during processing

Wang

et al. 2015

Journal of Functional Foods

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A B S T R A C THere we investigated the lipid-protective effects of Chinese red pepper (Zanthoxylum bungeanum Maxim.) leaf (ZML) extract and chlorogenic acid, hyperoside, and quercitrin on salted fish during processing. ZML extract and the polyphenols expressed high total antioxidant capacity and DPPH free radical scavenging activity. Salted fish with the ZML extract had higher endogenous antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activities, lower peroxide value (PV) and thiobarbituric acid-reactive substance (TBARS) values than that of the control. The negative correlation between the antioxidant enzyme activities and PV, or TBARS values of all samples was observed throughout the entire processing. These results indicated that ZML extract could effectively inhibit lipid oxidation in the salted fish and suggested its potential role in the protection against oxidative stress in processed meat.

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Section: 5supporting

confidence: 91%

Effects of pepper (Zanthoxylum bungeanum Maxim.) leaf extract on the antioxidant enzyme activities of salted silver carp (Hypophthalmichthys molitrix) during processing

Wang

et al. 2015

Journal of Functional Foods

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“…Chronic and repeated UV exposure induces DNA mutations in some genes, such as SCF and ET-1, in keratinocytes, which can stimulate melanocytes to synthesize large amounts of melanin and may be responsible for causing clinical solar lentigenes. 46 Chlorogenic acid shows protective effects on cells, such as neurons, [47][48][49] erythrocytes, 50 and leukocytes. It is hypothesized that coffee polyphenols, chlorogenic acids, and their products in the circulation may play specific roles in reducing the hyperpigmentation in pigmented spots.…”

Section: Discussionmentioning

confidence: 99%

“…44 Ferulic acid, a major phenolic component, appears in the circulation after the consumption of coffee 45 and eliminated c-ray-induced DNA damage in rats. 46 Chlorogenic acid shows protective effects on cells, such as neurons, [47][48][49] erythrocytes, 50 and leukocytes. 51 Coffee drinkers are repeatedly fueling phenolic compounds in their body, which results in lower macromolecule oxidation.…”

Section: Discussionmentioning

confidence: 99%

Skin photoprotection and consumption of coffee and polyphenols in healthy middle‐aged Japanese females

Fukushima¹,

Takahashi

Hori

et al. 2014

Int J Dermatology

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“…Bunun için birçok çalışmada, doğal bitkisel ürünlerin ham ve saflaştırılmış formları kullanılarak anti-kanser ilaçların neden olduğu yan etkileri azaltılması için çalışmalar sürdürülmektedir (7,8).…”

Section: Introductionunclassified

Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin’in Yararlı Etkileri

Çağlayan¹

2017

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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Öz: Karaciğer toksisitesi, kemoterapötik bir ilaç olan methotrexate (MTX) terapisinin komplikasyonlarının sonucunda oluşur. Silymarin (SLY) ve naringin (NRG) antioksidant, anti-inflamatuvar ve anti-hiperlipidemik gibi birçok farmakolojik özelliklere sahip biyoflavonoidlerdir. Bu çalışma ratlarda MTX kaynaklı karaciğer toksisitesi üzerine SLY ve NRG'in yararlı etkilerinin araştırılması için yapılmıştır. Ratlara (20 mg/kg) tek doz periton içi MTX verildikten sonra 7 gün boyunca (25 ve 50 mg/kg) SLY ve (50 ve 100 mg/kg) NRG tedavisi oral yoldan gavaj ile verilmiştir. MTX; süperoksit dismutaz (SOD), katalaz (KAT) ve glutatyon peroksidaz (GPx) gibi antioksidan enzim aktivitelerini ve glutatyon (GSH) seviyesini azaltıp, lipid peroksidasyonunu artırarak oksidatif hasarı tetiklediği belirlenmiştir. Üstelik MTX toksikasyonu aspartat amino transferaz (AST), alanin amino transferaz (ALT) ve alkalin fosfataz (ALP) gibi karaciğer enzim aktivitelerini artırmıştır. Diğer taraftan SLY ve NRG tedavisi GSH seviyesini ve antioksidan enzim aktivitelerini artırıp, lipid peroksidasyonunu inhibe etmiştir. Ayrıca SLY ve NRG tedavisi, MTX grubu ile karşılaştırıldığında karaciğer enzim aktivitelerini azalttığı belirlenmiştir. Bu çalışmada SLY ve NRG, MTX'ın neden olduğu karaciğer toksisitesine karşı yararlı etki sağlamıştır.Anahtar Kelimeler: Karaciğer enzimleri, Methotrexate, Naringin, Oksidatif stress, Silymarin. Beneficial Effects of Silymarin and Naringin Against Methotrexate-induced Hepatotoxicity in RatsAbstract: Hepatotoxicity occurs as a result of the complications of methotrexate (MTX) therapy, which is a chemotherapeutic drug. Silymarin (SLY) and naringin (NRG) are bioflavonoids possess multiple pharmacological properties such as antioxidant, anti-inflammatory and anti-hyperlipidemic activity. This study was undertaken to investigate the beneficial effects of SLY and NRG on MTX-induced liver toxicity in rats. After a single dose of intraperitoneal MTX (20 mg/kg) was given to rats, SLY (25 and 50 mg/kg) and NRG (50 and 100 mg/kg) treatment was given by oral gavage for 7 days. It has been determined that MTX induces oxidative stress by increasing lipid peroxidation, decreased in glutathione (GSH) level and antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Moreover, MTX toxication has increased liver enzyme activities such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). On the other hand, SLY and NRG treatment increased the level of glutathione (GSH) and antioxidant enzyme activities and inhibited lipid peroxidation. It has also been determined that SLY and NRG treatment reduces liver enzyme activities when compared to the MTX group. In this study, SLY and NRG provided a beneficial effect against MTXinduced liver toxicity.

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Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats

Cited by 37 publications

References 33 publications

Effects of pepper (Zanthoxylum bungeanum Maxim.) leaf extract on the antioxidant enzyme activities of salted silver carp (Hypophthalmichthys molitrix) during processing

Effects of pepper (Zanthoxylum bungeanum Maxim.) leaf extract on the antioxidant enzyme activities of salted silver carp (Hypophthalmichthys molitrix) during processing

Skin photoprotection and consumption of coffee and polyphenols in healthy middle‐aged Japanese females

Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin’in Yararlı Etkileri

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