Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model

Melekoğlu, Rauf; Çiftçi, Osman; Eraslan, Sevil; Çetin, Aslı; Başak, Neşe

doi:10.1186/s13048-018-0409-9

Cited by 116 publications

(73 citation statements)

References 27 publications

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“…Cisplatin-induced ovarian toxicity was reported to reduce with the use of anti-oxidants such as mesna [42], mirtazapine [43], and sildena l [30]. Curcumin and capsaicin were shown to reduce tissue oxidative stress markers and improve histological parameters in cyclophosphamide administered rats [44].…”

Section: Discussionmentioning

confidence: 99%

Investigation of TAp63 gene Expression and Follicle Count Using Melatonin in Cisplatin-induced Ovarian Toxicity

Şahin

Duran

Sılan

et al. 2020

Preprint

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Background: Premature ovarian failure is among the most important side effects of chemotherapy during reproductive period. Preserving ovarian function is gradually gaining importance during oncologic treatment. The present study aims to investigate the potential of melatonin to protect from cisplatin-induced ovarian toxicity in rats. Twenty nine female rats were divided to three groups: Saline control group (Group 1), cisplatin group (Group 2), and cisplatin+melatonin group (Group 3). While the rats in Groups 2 and 3 were administered 5 mg/kg single dose of cisplatin via intra-peritoneal (IP) route, the rats in Group 3 were started on melatonin (20 mg/kg IP) before cisplatin administration and continued during 3 consecutive days. Ovaries were removed one week after cisplatin administration in all groups. Blood samples were obtained before the rats were decapited. Histological evaluation, follicle count, and classification were performed. TAp63 mRNA expression was evaluated using mRNA extraction and real-time polymerase chain reaction (PCR) method. Serum estradiol (E2) and anti-mullerian hormone (AMH) values were measured with enzyme immune-assay technology. Results: While primordial follicles were seen to decrease in Group 2 as compared to Group 1 (p:0.023), primordial follicle count was observed to be preserved significantly in melatonin group as compared to Group 2 (p:0.047). Moreover, cisplatin-induced histo-pathological morphology was preserved in favor of normal histology in melatonin group. A significant difference was not observed between groups with regard to mean serum AMH and E2 values (p:0.102 and p:0.411, respectively). While TAp63 gene expression significantly increased in Group 2 as compared to control group (p:0.001), we did not detect a statistically significant difference in cisplatin+melatonin group, although gene expression decreased (p:0.34). Conclusion: We conclude that concurrent administration of melatonin and cisplatin may protect from ovarian damage.

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Section: Discussionmentioning

confidence: 99%

Investigation of TAp63 gene Expression and Follicle Count Using Melatonin in Cisplatin-induced Ovarian Toxicity

Şahin

Duran

Sılan

et al. 2020

Preprint

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“…It inhibits the Nuclear factor-kappa beta pathway 14 , which plays an essential role in the aetiology of tumorigenesis and at the same time affects the cell cycle homeostasis negatively. It produces this effect indirectly by inhibiting the synthesis of transient receptor potential vanilloid receptors 15 . CRC produces antioxidant and anti-inflammatory activity by inhibiting the synthesis of the inducible nitric oxide synthase enzyme and inflammatory cytokines (such as interleukin-1β and 6).…”

Section: ■ Discussionmentioning

confidence: 99%

The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

et al. 2018

Self Cite

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Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.

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“…CRC and CPS treatment of rats with cyclophosphamide-induced POF had a beneficial effect on reducing ovarian damage by improving tissue oxidative stress marker levels, ovarian reserve marker levels, and histopathological parameters. The significant improvements in ovarian tissue histopathological damage and hormonal levels detected indicate that treatment with CRC or CPS might be a conservative treatment approach for cyclophosphamide-induced POF (Melekoglu et al 2018).…”

Section: Future Possibilitiesmentioning

confidence: 99%

Premature Ovarian Insufficiency

Gunning¹,

Troìa²,

Janse³

et al. 2020

Endocrinology

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In women diagnosed with premature ovarian insufficiency (POI), the resting pool of primordial follicles is prematurely exhausted. These women present with absent menses and increased follicle-stimulating hormone (FSH) concentrations along with low estrogens before 40 years of age. The underlying etiology in most cases remains unknown. In a small proportion of cases, POI results from genetic defects, autoimmune disease, or iatrogenic origin (such as surgery, radiotherapy, or chemotherapy). In the absence of contraindications, hormone replacement therapy (HRT) is recommended to mitigate short-and long-term physical and mental symptoms. Little prospectively generated information is available regarding long-term health risks associated with POI. Since fertility is severely compromised in women diagnosed with POI, IVF along with oocyte donation or adoption may be offered. In women at risk for POI, fertility preservation options can be considered.

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Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model

Cited by 116 publications

References 27 publications

Investigation of TAp63 gene Expression and Follicle Count Using Melatonin in Cisplatin-induced Ovarian Toxicity

Investigation of TAp63 gene Expression and Follicle Count Using Melatonin in Cisplatin-induced Ovarian Toxicity

The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

Premature Ovarian Insufficiency

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