Beneficial effects of Ebselen on corrosive esophageal burns of rats

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

“…Günel et al, [30] found that reactive oxygen radicals increased during the early phase of esophageal burns. In another study, Ocakci et al, [17] showed that NaOH treatment increased lipid peroxidation. In corrosive esophageal burns, while SI and HDS are the most important indicators of esophageal damage, the hydroxyproline level is an indicator collagen accumulation.…”

“…Tissues were scored in three categories for a total score of 0-5 (Table 1). [17] For the SI evaluation, the esophageal wall thickness and luminal diameters were measured using a millimetric ocular microscope (Olympus BX53, Tokyo, Japan). For the SI calculation, the averages of the measurements taken from four different locations by two pathologists were used.…”

Влияние Антиоксидантов На Репарацию Тканей Пищевода После Экспериментального Химического Ожога Уксусной Кислотой

“…Âûäåëåíèå ñâîáîäíûõ ðàäèêàëîâ ïðîèñõîäèò íå òîëüêî â ìîìåíò êîíòàêòà õèìè÷åñêîãî àãåíòà ñî ñëèçèñòîé îáîëî÷êîé îðãàíà, íî è íà ïðîòÿaeåíèè âñåãî âðåìåíè ðåçîðáöèè äàííîãî àãåíòà.  äàëüíåéøåì ïîäêëþ÷àþòñÿ ìåõàíèçìû ýíäî-ãåííîãî ïîääåðaeàíèÿ îêèñëèòåëüíîãî ñòðåññà, ÷òî â ñâîþ î÷åðåäü óìåíüøàåò òåìïû çàaeèâëåíèÿ îaeîãîâûõ ðàí [2,3,5,9,10].…”