Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Mansouri, Mohammad Taghi; Farbood, Yaghoob; Naghizadeh, Bahareh; Shabani, Sohreh; Mirshekar, Mohammad Ali; Sarkaki, Alireza

doi:10.3109/13880209.2015.1137601

Cited by 44 publications

(26 citation statements)

References 30 publications

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“…Ellagic acid (E) is a naturally occurring phenolic compound found in grapes, nuts, strawberries, raspberries, green tea, pomegranates, as well as royal jelly and honey . Ellagic acid has received considerable attention because of its extensive array of biological properties including potent antioxidant, antiapoptotic, antiinflammatory, cardioprotective, ulcer healing, antifibrotic, antidiabetic, hypolipidemic, and antiatherosclerotic properties …”

Section: Introductionmentioning

confidence: 51%

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Georgy

Maher²

2017

J Biochem Mol Toxicol

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The anticancer drug doxorubicin causes testicular toxicity as an undesirable effect. The present study was undertaken to investigate the possible protection of ellagic acid and rosmarinic acid during doxorubicin administration. For this purpose eight groups of male Sprague-Dawley rats were used (n = 10), one group received vehicle served as control, and other groups received 5 mg/kg doxorubicin twice a week for 2 weeks for a cumulative dose of 20 mg/kg, ellagic acid (10 mg/kg/day, 14 consecutive days p.o.), rosmarinic acid (75 mg/kg/day, 14 consecutive days p.o.), ellagic acid and rosmarinic acid. The latter three regimens were given to control and doxorubicin-received rats. Doxorubicin decreased testicular relative weight, sperm count, motility, serum testosterone, testicular glycogen, and sialic acid with increased incidence of histopathological changes, oxidative stress, tumor necrosis factor-alpha, as well as cholinesterase activity. Conversely, ellagic and rosmarinic acid treatment ameliorated such damage, thus showing the possibility to use as an adjuvant during doxorubicin treatment.

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Section: Introductionmentioning

confidence: 51%

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Georgy

Maher²

2017

J Biochem Mol Toxicol

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“…More pharmacokinetic studies of EGA are needed to elucidate the differential actions of EGA and urolithins. One of the scientific reports in the literature suggested that EGA can have neuroprotective potential [12] and it is supposed to enhance cholinergic function and prevent long-term potentiation deficits in different brain regions of rats [13,14]. These studies made us to propose the positive impact of EGA in the management of dementia of SAD type.…”

Section: Ellagic Acid Administration Negated the Development Of Strepmentioning

confidence: 98%

Ellagic Acid Administration Negated the Development of Streptozotocin-Induced Memory Deficit in Rats

Bansal¹,

Yadav²,

Kumar³

2017

Drug Res (Stuttg)

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Rampant production of pro-oxidants and inadequate antioxidant availability in brain exert oxidative stress, which in synergism with impaired glucose metabolism and inflammation leads to neurodegeneration and cognitive deficits. Ellagic acid (EGA) is a phenolic compound present in various fruits and is reported to possess robust antioxidant and anti-inflammatory properties. The present study investigated the effect of EGA administration on streptozotocin (STZ) induced dementia in rats. Bilateral intracerebroventricle (ICV) injection of STZ (3 mg/kg) was given to Wistar rats (200 g) on day 1 and 3. EGA (17.5 and 35 mg/kg) was administered orally to rats for 28 days daily. The spatial memory of rats was quantified by using Morris water maze and elevated plus maze. Brain TBARS, GSH and TNF-α were also measured. Administration of EGA prevented the induction of STZ-ICV triggered cognitive deficits as evident by a significant (p<0.05) reduction in mean escape latency during acquisition trial and increased (p<0.05) time spent in target quadrant during retrieval trial in Morris water maze test, and reduction (p<0.05) in transfer latency in elevated plus maze test. Furthermore, both the doses of EGA attenuated STZ-ICV induced rise in brain TBARS as well as TNF-α and simultaneously enhanced the GSH content. Thus, EGA ameliorated STZ-induced dementia by probably restoring the balance between cellular pro-oxidants and anti-oxidants in brain of rats.

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“…Of particular interest for this study is the reported ability of EA to lower the rotenone-induced generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in PC12 cells [22] as well as its ability to exhibit a neuroprotective effect against oxidative damage in diabetic rats by suppressing oxidative stress [23]. From cognitive and behavioral points of view, EA prevents scopolamine-and diazepam-induced cognitive impairments [24,25] and may be of potential benefit in brain stroke by alleviating the oxidative stress characteristic for this condition [26]. Data also supports EA's brain-protective properties against 6-OHDA-induced neuroinflammation in rats as well as cognitive and long-term potentiation deficits following traumatic brain injury [27].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study

et al. 2020

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We compared the neuroprotective action of three natural bio-antioxidants (AOs): ellagic acid (EA), α-lipoic acid (LA), and myrtenal (Myrt) in an experimental model of Parkinson’s disease (PD) that was induced in male Wistar rats through an intrastriatal injection of 6-hydroxydopamine (6-OHDA). The animals were divided into five groups: the sham-operated (SO) control group; striatal 6-OHDA-lesioned control group; and three groups of 6-OHDA-lesioned rats pre-treated for five days with EA, LA, and Myrt (50 mg/kg; intraperitoneally- i.p.), respectively. On the 2nd and the 3rd week post lesion, the animals were subjected to several behavioral tests: apomorphine-induced rotation; rotarod; and the passive avoidance test. Biochemical evaluation included assessment of main oxidative stress parameters as well as dopamine (DA) levels in brain homogenates. The results showed that all three test compounds improved learning and memory performance as well as neuromuscular coordination. Biochemical assays showed that all three compounds substantially decreased lipid peroxidation (LPO) levels, and restored catalase (CAT) activity and DA levels that were impaired by the challenge with 6-OHDA. Based on these results, we can conclude that the studied AOs demonstrate properties that are consistent with significant antiparkinsonian effects. The most powerful neuroprotective effect was observed with Myrt, and this work represents the first demonstration of its anti-Parkinsonian impact.

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Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Cited by 44 publications

References 30 publications

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Ellagic Acid Administration Negated the Development of Streptozotocin-Induced Memory Deficit in Rats

Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study

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