Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis

Munguía, Levy; Ortiz, Miguel; González-Ruiz, Cristian; Portilla, Andrés; Meaney, Eduardo; Villarreal, Francisco; Nájera, Nayelli; Ceballos, Guillermo

doi:10.1089/jmf.2021.0054

Cited by 14 publications

(13 citation statements)

References 124 publications

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“…Our result suggests that flavonoid supplementation has a beneficial effect on appendicular muscle mass which is recognized to be responsible for locomotion and physical independence, similar to a recently published systematic review and meta-analysis indicating that flavonoid improved muscle cross-sectional area and muscle mass ( 39 ). Muscle fiber loss and muscle fiber atrophy are the main mechanisms of muscle deterioration with aging.…”

Section: Discussionsupporting

confidence: 89%

Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials

Liu

Tan

et al. 2022

Front. Nutr.

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The role of flavonoids in regulating the synthesis and function of skeletal muscles is increasingly recognized. However, randomized controlled trials have yielded inconsistent results on the influence of flavonoids on human muscular parameters. Therefore, we performed a meta-analysis to evaluate the possible effects of flavonoids on sarcopenia-related parameters in middle-aged and elderly people. Eligible literature and randomized controlled trials reports have been extensively searched from PubMed, Cochrane Library, Web of Science, and EMBASE databases until April 2022. A total of 20 articles involving 796 participants were available for the meta-analysis. There were significant benefits for participants in appendicular muscle mass gain (SMD = 0.29; 95% CI: 0.07, 0.52; P = 0.01) and 6-min walk distance (SMD = 0.37; 95% CI: 0.01, 0.73; P = 0.05). A subgroup analysis indicated that flavonoid significantly improves appendicular muscle mass (SMD = 0.50; 95% CI: 0.21, 0.80; P < 0.01) and Timed-Up and Go test (SMD = −0.47; 95% CI: −0.85, −0.09; P = 0.02) in Sarcopenia population. Our results provide insight into the effects of flavonoids on skeletal muscle mass and gait speed for those without exercise. However, there was no significant improvement in the subjects' muscle strength.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=334383, identifier: CRD42022334383.

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Section: Discussionsupporting

confidence: 89%

Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials

Liu

Tan

et al. 2022

Front. Nutr.

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“…Messina S et al found that five weeks of soy isoflavone supplementation blunted TNF-α, NF-κB, and MAPKs activation and ameliorated muscle function in mdx mice [ 41 ]. Similarly, it was suggested by Munguia L et al that flavonoids could be used as a potential strategy for preventing muscle loss in adults [ 23 ]. Consistent with these studies, the present study found that a moderate (four times per week) consumption of soy food was significantly associated with an increased HGS (1.1 kg) compared to the low (<1 time per week) consumption of soy food in general Chinese adults.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a 6-month four-arm randomized controlled trial study of 123 Chinese older adults showed that supplementation with soy protein can prevent muscle mass loss and physical performance decline [ 22 ]. Moreover, another meta-analysis conducted by Munguia L et al found that flavonoids have beneficial effects on skeletal muscle metabolism and mitochondria function, and thereby could be used as a potential tool in preventing skeletal muscle loss [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Soy Food Consumption Is Inversely Associated with Handgrip Strength: Results from the TCLSIH Cohort Study

et al. 2023

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Background: Soy foods contain high levels of soy protein or isoflavones, which can stimulate muscle protein synthesis and increase antioxidant capacity, and thus ameliorate muscle strength decline. However, data from epidemiological studies investigating the association of habitual soy food consumption with muscle strength decline among general Chinese adults are limited. Methods: This study included 29,525 participants (mean age: 41.6 years; 16,933 (53.8%) males). Soy food consumption was evaluated using a validated 100-item food frequency questionnaire. Handgrip strength (HGS) was assessed with a hand dynamometer. Analysis of covariance were performed to assess the multivariable-adjusted least square means (LSM) and 95% confidence interval (CI) for HGS. Results: The multiple adjusted LSM (95% CI) of HGS across soy food consumption were 35.5 (34.2, 37.1) kg for <1 time per week, 36.1 (34.6, 37.6) kg for 1 time per week, 36.3 (34.8, 37.8) kg for 2–3 times per week, and 36.6 (35.1, 38.0) kg for ≥4 times per week (p for trend < 0.001). Compared to participants with soy food consumption less than one time per week, the multiple adjusted odds ratio (95% CI) of low HGS was 0.638 (0.485, 0.836) when the weekly consumption was ≥ 4 times (p for trend < 0.01). Conclusions: Higher habitual soy food consumption was positively associated with HGS in general Chinese adults. Consumption of soy foods may have beneficial effects on muscle health.

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“…Based on this finding, a study assessing the supplementation with a citrus flavonoid against postmenopausal mouse models resulted in higher locomotor activity, maintenance of muscle mass, reduction of muscle diacylglycerol content, and changes in muscle lipid metabolism 35 . A recent systematic review found that flavonoids would be muscular regulators because of their effects on the metabolism and mitochondrial function, thereby preventing muscle loss 36 . Another interesting finding was that psychosocial symptoms significantly improved in the third month of follow-up among those receiving either dose of the herbal compound, compared with those receiving EPT.…”

Section: Discussionmentioning

confidence: 99%

Short-term effects and safety of a natural oral supplement containing glucosinolates, phytosterols, and citrus flavonoids compared with hormone treatment for the management of postmenopausal symptomatic women: a pilot single-center randomized phase 2 clinical trial

Villar-López,

Soto-Becerra,

Chedraui

et al. 2023

Menopause

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Objective This study aimed to evaluate the short-term efficacy and safety of an oral herbal supplement containing glucosinolates, phytosterols, and citrus flavonoids for menopausal symptoms in comparison with estrogen plus progestogen therapy (EPT) among postmenopausal women. Methods This was a pilot single-blinded, three-armed phase II randomized clinical trial, controlled with EPT. Sixty participants were randomly assigned to receive treatment for 3 months: (1) an oral herbal supplement of 1,500 mg/d (G1, n = 20), (2) an oral herbal supplement of 3,000 mg/d (G2, n = 20), or (3) conjugated equine estrogens 0.625 mg/d plus medroxyprogesterone acetate of 5 mg/d (EPT group, n = 20). The primary endpoint was the intensity of menopausal symptoms as measured using the Menopause-Specific Quality of Life Questionnaire (global and domain scores). The Menopause-Specific Quality of Life Questionnaire uses a 7-point scale to rate the symptom intensity, with higher scores indicating severity. The secondary endpoints were hormonal, lipid, and safety profiles. Results Fifty-four participants (n = 54) completed the study. The mean, model-estimated, and global menopausal symptom scores at 3 months were 85.8 in the EPT group, 61.3 in G1, and 62.5 in G2. Participants treated with the herbal compound had lower global (13.7 [6.9-20.4], P < 0.001) and physical symptom scores (6.6 [1.6-11.5], P = 0.002) on the second month and lower psychosocial symptom scores (3.8 [1.3 to 6.3], P < 0.001) on the third month of follow-up, compared with EPT. Conversely, participants receiving EPT showed better outcomes on vasomotor symptoms since the first month of treatment (−6.1 [−8.3 to −4.0], P < 0.001). The EPT group exhibited higher values of estradiol and lower follicle-stimulating hormone and luteinizing hormone since the first month of follow-up. Also, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were significantly higher in this group than in G2. Conclusions In this small single-blind exploratory trial, the oral herbal supplement was more efficacious in reducing global, physical, and psychosocial menopausal symptoms in the short term than EPT. However, further studies are needed to adequately assess the efficacy and safety of this herbal supplement in the treatment of menopausal symptoms.

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Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis

Cited by 14 publications

References 124 publications

Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials

Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials

Soy Food Consumption Is Inversely Associated with Handgrip Strength: Results from the TCLSIH Cohort Study

Short-term effects and safety of a natural oral supplement containing glucosinolates, phytosterols, and citrus flavonoids compared with hormone treatment for the management of postmenopausal symptomatic women: a pilot single-center randomized phase 2 clinical trial

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