Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats

Sudhakara, G.; Mallaiah, P; Sreenivasulu, N.; Rao, B. Sasi Bhusana; Rajendran, R.; Desireddy, Saralakumari

doi:10.1007/s13105-013-0304-1

Cited by 33 publications

(22 citation statements)

References 52 publications

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“…Several studies had revealed that high fat diet could cause hepatic steatosis, hyperlipidemia, hyperinsulinemia, obesity, insulin resistance and other lipid metabolism disorder disease in humans and in laboratory animals [ 1 , 2 ]. The results of the present study showed that high-fat diet led to significant increase in body weight, hyperlipidemia, hyperglycemia, hyperinsulinemia, and hepatic lipid accumulation, which were in agreement with previous studies [ 1 , 2 , 23 ]. Phenolic compounds, which are widespread in plants, showed therapeutic effects to obesity and other HFD-induced disease [ 1 , 24 ].…”

Section: Discussionsupporting

confidence: 94%

“…As previously expressed, insulin resistance is another key pathophysiological feature and pathogenesis in high fat diet mice [ 2 , 20 , 21 ]. The hyperlipidemia and hyperglycemia induced by high fat diet could decrease the number of insulin receptors, glucose transport and metabolism thereby increasing insulin resistance and reducing insulin sensitivity [ 23 ]. Insulin signaling is a cascade of events initiated by the activation of insulin receptor substrates (IRS).…”

Section: Discussionmentioning

confidence: 99%

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Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Liu

Sun

et al. 2017

Nutrients

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The flavonoid-rich extract from Paulownia fortunei flowers (EPF) has been reported to prevent obesity and other lipid metabolism disease. However, the mechanism of its protective effects is not yet clear. The objective of this study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of EPF in obese mice fed a high-fat diet (HFD). Male h ICR (Institute of Cancer Research) mice were fed a HFD containing or not containing the EPF (50 or 100 mg/kg) for eight weeks. EPF reduced body weight gain, lipid accumulation in livers and levels of lipid, glucose and insulin in plasma as well as reduced insulin resistance as compared with the HFD group. EPF significantly decreased serum aminotransferase activity of the HFD group. We observed that EPF administration significantly increased the level of AMP-activated kinase (AMPK) phosphorylation and prevented fat deposits in livers and HepG2 cells, but these effects were blocked by compound C (an AMPK inhibitor). The protective effects of EPF were probably associated with the decrease in HMGCR, SREBP-1c and FAS expressions and the increase in CPT1 and phosphor-IRS-1 expressions. Our results suggest that EPF might be a potential natural candidate for the treatment and/or prevention of overweight and hepatic and metabolic-related alterations induced by HFD.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Liu

Sun

et al. 2017

Nutrients

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“…Kumar et al [55] reported the potential of C. attenuate in the treatment of diabetes. Similarly, C. fimbriata may be beneficial for the suppression of high-fat dietinduced insulin resistance and oxidative stress [56].…”

Section: Non-enzymatic Antioxidant Contentsmentioning

confidence: 99%

Free-radical-scavenging and antioxidant capacities with special emphasis on enzyme activities andin vitrostudies inCaralluma flavaN. E. Br.

Karthishwaran

Shamisi

Kurup

et al. 2017

Biotechnology & Biotechnological Equipment

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Caralluma flava is a perennial, succulent edible plant distributed in the hillsides of the United Arab Emirates. In order to validate its use in the traditional system as an edible and medicinal source, we evaluated the antioxidant and in vitro free-radical-scavenging properties of its ethanol extract. The antioxidant activity of the extract was evaluated in vitro by 2,2'-azino-bis-3-ethylbenzothiazoline-6sulfonic acid (ABTS + ), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), hydroxyl radical and nitric oxide radical scavenging assays. The antioxidant enzyme activities (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymatic antioxidant contents (total reduced glutathione, and Vitamin E and Vitamin C) in the extracts were also determined. The total phenolics content of the plant extract was 10.14 mg/g and the flavonoid content was 4.13 mg/g. The results showed a positive linear correlation between these phytochemicals and the free-radical-scavenging activities. The C. flava extract exhibited significant radical-scavenging properties in the ABTS( + ), DPPH( ), hydroxyl radical and nitric oxide radical assays. The study revealed that C. flava could be considered an excellent source of enzymatic and non-enzymatic antioxidants. The results indicate that the plant extract has potent free-radical-scavenging activity and ability to prevent radical chain reactions. Based on the results obtained, C. flava seems to be a very promising species for further investigation in order to identify the compounds responsible for its biological activity.

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“…7 This plant has been investigated for its myriad biological effects such as antihyperglycaemic and hypolipidaemic, hepatoprotective, antioxidant activity and came out with promising results. [8][9][10] In light of above reports, it is reasonable to assume that this plant could have anticancer potential. Hence, in this study we investigated the cytotoxic potential of C. fimbriata ethanolic leaf extract against human COLO 320 cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Ashwini¹,

Ezhilarasan²,

Anitha³

2017

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Aim: The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of Caralluma fimbriata in the COLO 320 cell line. Materials and Method: The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of Caralluma (100 -300 µg/ml) for 24 h. The cell viability and IC 50 was calculated from the cytotoxicity. The morphology of the Caralluma treated cells, control, and positive control were observed under reverse phase inverted microscope. Result: The C. fimbriata ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 µg with an IC 50 value of 233.87 µg. Conclusion: The present study shows that the ethanolic leaf extract of Caralluma fimbriata is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.

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Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats

Cited by 33 publications

References 52 publications

Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Free-radical-scavenging and antioxidant capacities with special emphasis on enzyme activities andin vitrostudies inCaralluma flavaN. E. Br.

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

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