Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis

Marabinil, S.; Ciabatti, Pier Guido; Polli, G.; Fusco, Bruno M.; Geppettil, P.

doi:10.1007/bf00173655

Cited by 32 publications

(26 citation statements)

References 15 publications

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“…There is good evidence (as reviewed in Baraniuk, 2001;Lacroix and Landis, 2008) that in upper airway mucosa, neurogenic inflammation is involved in the TRP Channels as Drug Targets pathogenesis of rhinosinusitis. Indeed, TRPV1 expression is increased in the nasal mucosa of patients with vasomotor rhinitis (Van Gerven et al, 2013) and therapy employing intranasal capsaicin desensitization provides symptomatic relief in these individuals (Marabini et al, 1991). This procedure is, however, poorly tolerated (painful) and thus has not been widely adopted.…”

Section: B Transient Receptor Potential Channels Inmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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Section: B Transient Receptor Potential Channels Inmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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“…Topically, capsaicin has therapeutic value in a variety of neuropathic pain conditions including rheumatoid arthritis, cluster headaches, herpes zoster, and vasomotor rhinitis (2)(3)(4)(5). Furthermore, capsaicin decreases the growth of human leukemic cells (6)(7)(8), gastric (9), and hepatic carcinoma cells in vitro (10).…”

Section: Introductionmentioning

confidence: 99%

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

et al. 2006

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Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax. Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but also AR. Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via downregulation of expression of AR, but also by a direct inhibitory effect on PSA transcription. Capsaicin inhibited NF-K activation by preventing its nuclear migration. In further studies, capsaicin inhibited tumor necrosis factor-A-stimulated degradation of IKBA in PC-3 cells, which was associated with the inhibition of proteasome activity. Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IKBA, preventing the activation of NF-KB. Capsaicin, when given orally, significantly slowed the growth of PC-3 prostate cancer xenografts as measured by size [75 F 35 versus 336 F 123 mm 3 (FSD); P = 0.017] and weight [203 F 41 versus 373 F 52 mg (FSD); P = 0.0006; capsaicin-treated versus vehicletreated mice, respectively]. In summary, our data suggests that capsaicin, or a related analogue, may have a role in the management of prostate cancer. (Cancer Res 2006; 66(6): 3222-9)

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“…The hypothesis that a hyperactive nonadrenergic, noncholinergic, peptidergic neural system is the underlying pathophysiology in IR was corroborated by Lacroix et al [26], who reported an increased concentration of neuropeptides in a group of chronic IR patients, improvement of symptoms by local treatment of capsaicin giving a 50% reduction in CGRP-Li (CGRP-like immunoreactivity) content in nasal biopsies [42], and a correlation between symptom intensity and CGRP-Li concentration in nasal mucosa [43]. Several studies have been published showing a therapeutic effect in IR patients for repeated topical applications of capsaicin [44][45][46]. In a recent paper, van Rijswijk et al [47•] showed that repeated administration of capsaicin in a double-blind, placebo-controlled trial led to a significant and long-term reduction of symptoms.…”

Section: Capsaicin Treatment In Idiopathic Rhinitismentioning

confidence: 51%

Capsaicin treatment of idiopathic rhinitis: The new panacea?

Rijswijk¹,

Wijk

2006

Curr Allergy Asthma Rep

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The management of patients with perennial nonallergic or idiopathic rhinitis is difficult. Diagnosis and treatment are hampered by several factors. First, the diagnosis is made by exclusion of other nasal diseases. As a consequence, idiopathic rhinitis is not defined according to clear-cut criteria. A commonly accepted phenotype of idiopathic rhinitis does not exist. Second, the pathophysiology of idiopathic rhinitis is not yet fully elucidated. In contrast with allergic rhinitis, inflammation does not appear to play an important role in idiopathic rhinitis. Recent studies indicate a neural dysregulation of the nasal mucosa. Additionally, the available therapeutic arsenal comprising both pharmacotherapy and surgery is at best partially efficacious in these patients. The efficacy of repeated capsaicin application has been established in several randomized controlled trials. This treatment modality may be the first step to more specific and better treatment options for patients with idiopathic rhinitis that is unresponsive to standard treatment.

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Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis

Cited by 32 publications

References 15 publications

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

Capsaicin treatment of idiopathic rhinitis: The new panacea?

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