Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats

Abstract

Background. Anti-inflammatory and immunomodulatory activities have been reported for maprotiline, a strong norepinephrine reuptake inhibitor. In addition, some other antidepressant drugs have shown beneficial effects in experimental colitis. Methods. All the animals were divided into normal and depressed groups. In normal rats colitis was induced by instillation of 2 mL of 4% acetic acid and after 2 hours, maprotiline (10, 20, and 40 mg/kg, i.p.) was administered. In reserpinised depressed rats, depression was induced by injection of reserpine (6 mg/kg, i.p.), 1 h prior to colitis induction, and then treated with maprotiline (10, 20, and 40 mg/kg). Treatment continued daily for four days. Dexamethasone (1 mg/kg, i.p.) was given as a reference drug. On day five following colitis induction, animals were euthanized and distal colons were assessed macroscopically, histologically, and biochemically (assessment of myeloperoxidase activity). Results. Maprotiline significantly improved macroscopic and histologic scores and diminished myeloperoxidase activity in both normal and depressed rats while reserpine exacerbated the colonic damage. Conclusion. Our data suggests that the salutary effects of maprotiline on acetic acid colitis are probably mediated first through depressive behavioral changes that could be mediated through the brain-gut axis and second for the anti-inflammatory effect of the drug.

Periodontal status in chronic periodontitis depressed patients on desvenlafaxine: An observational study

“…[ 8 ] Furthermore, venlafaxine has shown to reduce inflammatory injury in animal model of induced ulcerative colitis. [ 18 ] In addition, anti-nociceptive and anti-inflammatory effects of venlafaxine were also noticed by Aricioğlu et al . in rat model of inflammation.…”

Effect of Lactobacillus acidophilus on some Physiological and Immunological Aspects in Experimentally Induced Colitis in Rats

“…These changes might be contribute to food intake and body weight dropping denoted in the present study. Abnormal integrity of intestinal wall in colitis consequently defected in the adsorptive function of the intestine leading to malabsorbance of protein and fats with anorexia (malnutrition of protein and fat) which caused decrease of protein and lipid synthesis in liver and weight loss during the first periods of experiment (Minaiyan et al, 2015). On the other hand, the effects of lactobacillus acidophilus on body weight and food intake was the subject of a difference between researchers.…”

“…Accordingly administration of L. acidophilus to colitis rats was efficient to improve intestinal wall integrity and consequently improve structural and absorptive features of intestine and prevent diarrhea (Minaiyan et al, 2015). These benefit effects could be attributed to either of the potential mechanisms of L. acidophilus in maintaining the flora of the gut and ongoing carbohydrate fermentation; and/or by competitively inhibiting the growth of pathogens (Oelschlaeger, 2010;Ng et al, 2009).…”

Evaluation of central and peripheral effects of doxepin on acetic acid-induced colitis in rat and the involved mechanisms

“…Our previous studies also demonstrated the anti-inflammatory activities of amitriptyline, fluvoxamine, maprotiline and venlafaxine (Hajhashemi et al, 2010[ 19 ], 2015[ 18 ]; Sadeghi et al, 2011[ 42 ], 2013[ 43 ]) and anti-colitis effects of maprotiline and fluvoxamine (Minaiyan et al, 2014[ 31 ], 2015[ 32 ]).…”