Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats

Hasanein, Parisa; Emamjomeh, Abbasali; Chenarani, Nasibeh; Bohlooli, Mussa

doi:10.1080/1028415x.2018.1533269

Cited by 29 publications

(14 citation statements)

References 49 publications

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“…Treatment with SiPE dose dependently and significantly ameliorated thermal hyperalgesia in the treated rats. Additionally, the increased occurrence of formalin elicited flinching responses in diabetic rats is indicative of abnormal responses to nociceptive stimuli, which has been extensively reported in previous studies (Kaur et al, 2017;Hasanein et al, 2020). In the present study the injection of formalin lead to a biphasic nocifensive flinching, licking or biting behaviour that was amplified in the diabetic animals.…”

Section: Discussionsupporting

confidence: 83%

“…Diabetes has also been reported to significantly affect pain response ( Kishore et al, 2018 ; Abo-Salem et al, 2020 ). Hyperalgesia, a condition that is exemplified by extreme sensitivity to painful stimuli is one of the most often encountered complication of diabetes, and it arises due to damages to peripheral nerves ( Lee-Kubli et al, 2014 ; Hasanein et al, 2020 ). Motor and sensory nerve conduction dysfunction, numbness and chronic pain are characteristics features that have been well documented to correlate with chronic hyperglycemia ( Edwards et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

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Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

2021

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Diabetic encephalopathy is one of the serious emerging complication of diabetes. Securidaca inappendiculata is an important medicinal plant with excellent antioxidant and anti-inflammatory properties. This study investigated the neuroprotective effects of S. inappendiculata polyphenol rich extract (SiPE) against diabetic encephalopathy in rats and elucidated the potential mechanisms of action. Type 2 diabetes mellitus (T2DM) was induced using high fructose solution/intraperitoneal injection of streptozotocin and the diabetic rats were treated with SiPE (50, 100 and 200 mg/kg) for 8 weeks. Learning and memory functions were assessed using the Morris water and Y maze tests, depressive behaviour was evaluated using forced swimming and open field tests, while neuropathic pain assessment was assessed using hot plate, tail immersion and formalin tests. After the experiments, acetylcholinesterase (AChE), oxidative stress biomarkers and proinflammatory cytokines, caspase-3 and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) were determined by ELISA kits. In addition, the expression levels of p38, phospho-p38 (p-p38), nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were determined by western blot analyses. The results indicated that SiPE administration significantly lowered blood glucose level, attenuated body weight loss, thermal/chemical hyperalgesia, improved behavioural deficit in the Morris water maze, Y maze test and reduced depressive-like behaviours. Furthermore, SiPE reduced AChE, caspase-3, NF-κB, malonaldehyde malondialdehyde levels and simultaneously increased antioxidant enzymes activity in the brain tissues of diabetic rats. SiPE administration also significantly suppressed p38 MAPK pathway and upregulated the Nrf2 pathway. The findings suggested that SiPE exerted antidiabetic encephalopathy effects via modulation of oxidative stress and inflammation.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

2021

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“…The rat was placed in the lighted chamber as in PAL training, and 5 seconds later, the guillotine door was raised, and the step-through latency (STLr) and the time spent in the dark compartment (TDC) were recorded up to 300 seconds. If the rat did not enter the dark compartment within 300 seconds, the retention test was terminated and a ceiling score of 300 seconds was assigned (Hasanein et al, 2020).…”

Section: Retention Testmentioning

confidence: 99%

Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Zhang¹,

Vatanpour

et al. 2022

European Journal of Psychology Open

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Abstract. Background: Exposure to music during pregnancy enhances brain development and improves learning in neonatal rats. Methods: In these experiments, we examined the effects of exposure to silence, hard rock, classical, and rap music in utero plus 60 days postpartum on learning and memory in adult Wistar rats. Passive avoidance learning (PAL) was assessed at age 60 days, and a retention test was done 24 hours after training. Elevated plus maze (EPM) was also used as a standard behavioral task for assessing the effects of music therapy on anxiety. Furthermore, we measured serum corticosterone levels and adrenal weight at the end of experiments to show the possible effect of stress on the rats’ behavior. Results: Hard rock music impaired acquisition, increasing the number of trials to acquisition in PAL task. Hard rock music also impaired the retrieval process by decreasing step-through latency and increasing time spent in the dark compartment during the retention trial. Further, in the hard rock group, there were increases in serum corticosterone and adrenal weight of rats. Classical music, in turn, improved acquisition learning and retention memory and decreased serum corticosterone levels compared to the silence group. Rats’ exposure to rap music did not show any significant change in acquisition and retrieval processes compared to the silence group. In the EPM task, classical music exposure had anxiolytic-like effects revealed in an increase in the number of entries into open arms and time spent in the open arms. However, in this task, hard rock music induced an anxiogenic effect. Conclusions: Prenatal and postnatal exposure to music improves PAL and memory in adult rats. The effects of music therapy with classical music might be related to stress reduction by lowering corticosterone as a stress biomarker or anxiolytic effects; this deserves further examination.

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“…A total of 18 novel trisaccharide fatty acid esters (noniosides A-O and others) were isolated specifically from the fruits of M. citrifolia [69]; however, there were no studies in diabetes animal models that demonstrated hypoglycemic effects promoted by noniosides from noni fruit. On the other hand, rutin, an important flavonoid found in M. citrifolia fruit [68], demonstrated an influence on hypoglycemic parameters [70,71] and also improved dyslipidemia in streptozotocin-induced diabetic rats [70].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Morinda citrifolia Linn. (Noni) Aqueous Fruit Extract on the Glucose and Lipid Metabolism in High-Fat/High-Fructose-Fed Swiss Mice

Inada

Silva

et al. 2020

Nutrients

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The aim of this study was to evaluate the therapeutic effects of two different doses (250 and 500 mg/kg) of Morinda citrifolia fruit aqueous extract (AE) in high-fat/high-fructose-fed Swiss mice. The food intake, body weight, serum biochemical, oral glucose tolerance test (OGTT), and enzyme-linked immunosorbent assay (ELISA), as well as histological analyses of the liver, pancreatic, and epididymal adipose tissue, were used to determine the biochemical and histological parameters. The chemical profile of the extract was determined by ultra-fast liquid chromatography–diode array detector–tandem mass spectrometry (UFLC–DAD–MS), and quantitative real-time PCR (qRT-PCR) was used to evaluate the gene expressions involved in the lipid and glucose metabolism, such as peroxisome proliferative-activated receptors-γ (PPAR-γ), -α (PPAR-α), fatty acid synthase (FAS), glucose-6-phosphatase (G6P), sterol regulatory binding protein-1c (SREBP-1c), carbohydrate-responsive element-binding protein (ChREBP), and fetuin-A. Seventeen compounds were tentatively identified, including iridoids, noniosides, and the flavonoid rutin. The higher dose of AE (AE 500 mg/kg) was demonstrated to improve the glucose tolerance; however, both doses did not have effects on the other metabolic and histological parameters. AE at 500 mg/kg downregulated the PPAR-γ, SREBP-1c, and fetuin-A mRNA in the liver and upregulated the PPAR-α mRNA in white adipose tissue, suggesting that the hypoglycemic effects could be associated with the expression of genes involved in de novo lipogenesis.

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Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats

Cited by 29 publications

References 49 publications

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Therapeutic Effects of Morinda citrifolia Linn. (Noni) Aqueous Fruit Extract on the Glucose and Lipid Metabolism in High-Fat/High-Fructose-Fed Swiss Mice

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