Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations

Mahmoodi, Merat; Ayoobi, Fatemeh; Aghaei, Azita; Rahmani, Mehdi; Taghipour, Zahra; Hosseini, Azar; Jafarzadeh, Abdollah; Sankian, Mojtaba

doi:10.1016/j.biopha.2018.08.078

Cited by 25 publications

(12 citation statements)

References 35 publications

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“…Plant products are generally the primary sources of dietary phytochemicals with beneficial effects, of which numerous compounds have ultimately been established in medicine consumed globally for varied illnesses, including inflammatory, autoimmune, and infectious diseases, metabolic and neurodegenerative diseases, and cancer (Banu & Kumar, 2009; Islam et al., 2019; Jayachandran et al., 2019; Kumar, Banu, et al., 2006; Kumar, Sharmila Banu, et al., 2008; Kumar, Sharmila Banu, Ganesan Murugesan, et al., 2007; Pandian et al., 2006; Pandian et al., 2006; Sinaga et al., 2016; Sukalingam et al., 2018). Additionally, numerous dietary phytochemicals belonging to the various traditional medicine systems (Chinese, Japanese, Indian, Turkish, Egyptian, African, and others) have been used by various peoples with AD, with or without the knowledge of primary general practitioners, for their beneficial potential (Hughes et al., 2016; Mahmoodi et al., 2019; et al., 2016; Rengasamy et al., 2019; Xiao et al., 2018).…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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The intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.

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Section: Autoimmune Diseasesmentioning

confidence: 99%

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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“…skorpilii showed moderate anti-inflammatory effect [70]. Moreover, the intraperitoneal administration of an ethanolic extract of T. vulgaris (50 and 100 mg/kg) in a rat model of experimental autoimmune encephalomyelitis (EAE), was able to decrease the cytokines production by splenocytes (IFN-γ, IL-6, and IL-17), while the amount of TGF-ß secretion was significantly higher [80]. The administration of hydromethanolic extracts of T. algeriensis and T. fontanesii (600 mg/kg) resulted in the reduction (62% and 52%) on carrageenan-induced leukocyte migration into the peritoneal cavity in mice model, while diclofenac (20 mg/kg) and dexamethasone (2 mg/kg) caused 39% and 30% of reduction, respectively [68].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Health-Promoting Effects of Thymus Phenolic-Rich Extracts: Antioxidant, Anti-inflammatory and Antitumoral Properties

2020

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Thymus genus comprises numerous species that are particularly abundant in the West Mediterranean region. A growing body of evidence suggests that many of these species are a rich source of bioactive compounds, including phenolic compounds such as rosmarinic acid, salvianolic acids and luteolin glycosides, able to render them potential applications in a range of industrial fields. This review collects the most relevant studies focused on the antioxidant, anti-inflammatory and anti-cancer of phenolic-rich extracts from Thymus plants, highlighting correlations made by the authors with respect to the main phenolic players in such activities.

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“…Furthermore, it decreased the production of pro‐inflammatory cytokines interferon‐ γ (IFN‐ γ ), interleukin‐6 (IL‐6) and interleukin‐17 (IL‐17) and increased the anti‐inflammatory cytokines interleukin‐10 (IL‐10) and transforming growth factor‐ β (TGF‐ β ). Moreover, the main active compound was carvacrol . EOs of Greek T. vulgaris attenuated the LPS‐induced elevation in the nuclear factor‐kappa (NF‐ κ B), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX‐2), TNF‐ α , NO and oxidative stress .…”

Section: Biological Activitiesmentioning

confidence: 99%

“…[47] Epifriedelinol (110) isolated from T. quinquecostatus, friedelinol (111) and friedelin (112) isolated from T. mongolicus are three friedelane-type triterpenes. [47,70] Daucosterol (113) and sitosterol (114) are two phytosterols isolated from this genus. [47,66]…”

Section: Terpenoids and Othersmentioning

confidence: 99%

“…Moreover, the main active compound was carvacrol. [113] EOs of Greek T. vulgaris attenuated the LPS-induced elevation in the nuclear factor-kappa (NF-κB), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), TNF-α, NO and oxidative stress. [7] On chemical view, thymol attenuated inflammatory response via regulating secretions of cytokines, and the suppression of NF-κB and mitogen-activated protein kinases signaling pathways both in vitro and in vivo.…”

Section: Anti-inflammation Activitymentioning

confidence: 99%

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Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Wang

et al. 2019

Chemistry & Biodiversity

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The genus Thymus (Lamiaceae) comprises about 214 species throughout the world, mainly found in North Africa, Europe, and temperate Asia zone. They are traditionally used as food additives and folk medicines. This review comprehensively summarizes information about traditional uses, chemical constituents, and biological activities of this genus and provides recommendations for future investigations. All information was gathered from scientific databases including Google Scholar, Sci‐Finder, Web of Science, ScienceDirect, and CNKI. Volatile oils are the most concerned constituents of this genus. Flavonoids, phenylpropanoids, tannins, organic acids, terpenoids, and phytosterols were also summarized. This genus plants possessed a variety of activities including antimicrobial, antioxidant, anti‐inflammatory, cytotoxic, analgesic, and antidiabetic. In brief, this review will be helpful to provide valuable data for explorations and create more interests towards Thymus genus in the future.

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Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations

Cited by 25 publications

References 35 publications

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

Health-Promoting Effects of Thymus Phenolic-Rich Extracts: Antioxidant, Anti-inflammatory and Antitumoral Properties

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

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