Beneficial effects of whole-body vibration exercise for brain disorders in experimental studies with animal models: a systematic review

Cardoso, André L.B.D.; Sá-Caputo, Danúbia da Cunha de; Asad, Nasser Ribeiro; Heuvelen, M J van; Zee, Eddy A. van der; Ribeiro‐Carvalho, Anderson; Bernardo-Filho, Mário

doi:10.1016/j.bbr.2022.113933

Cited by 10 publications

(9 citation statements)

References 92 publications

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“…In addition to the expected expression in brain blood vessel walls and meninges, collagen expression was observed in the granular layers of the hippocampus, where it may reflect extracellular matrix components. The presence of a neuronal cell surface feature, called perineuronal net (PNN), is consistent with a brain extracellular matrix (Bonneh-Barkay and Wiley, 2009). This PNN mainly covers the cell body and dendrites, is usually associated with neuroprotection, and plays an important role in learning, memory, and information processing in health and disease (Krishnawamy et al, 2021).…”

Section: E Ects On the Heartmentioning

confidence: 98%

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Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior

Tóth

Oroszi²,

Nyakas³

et al. 2023

Front. Aging Neurosci.

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BackgroundFemales with cardiovascular disease seem more vulnerable to develop concomitant mental problems, such as depression and cognitive decline. Although exercise is shown beneficial in cardiovascular disease as well as in mental functions, these patients may be incapable or unmotivated to perform exercise. Whole body vibration (WBV) could provide a passive alternative to exercise. Aim of the present study was to compare WBV to exercise after isoproterenol (ISO)-induced myocardial damage in female rats, regarding effects on heart, brain and behavior.MethodsOne week after ISO (70 mg/kg s.c., on 2 consecutive days) or saline injections, 12 months old female rats were assigned to WBV (10 minutes daily), treadmill running (30 minutes daily) or pseudo intervention for 5 weeks. During the last 10 days, behavioral tests were performed regarding depressive-like behavior, cognitive function, and motor performance. Rats were sacrificed, brains and hearts were dissected for (immuno)histochemistry.ResultsSignificant ISO-induced cardiac collagen deposition (0.67 ± 0.10 vs 0.18 ± 0.03%) was absent after running (0.45 ± 0.26 vs 0.46 ± 0.08%), but not after WBV (0.83 ± 0.12 vs 0.41 ± 0.05%). However, WBV as well as running significantly reduced hippocampal (CA3) collagen content in ISO-treated rats. Significant regional differences in hippocampal microglia activity and brain derived neurotrophic factor (BDNF) expression were observed. Significant ISO-induced CA1 microglia activation was reduced after WBV as well as running, while opposite effects were observed in the CA3; significant reduction after ISO that was restored by WBV and running. Both WBV and running reversed the ISO-induced increased BDNF expression in the CA1, Dentate gyrus and Hilus, but not in the CA3 area. Whereas running had no significant effect on behavior in the ISO-treated rats, WBV may be associated with short-term spatial memory in the novel location recognition test.ConclusionAlthough the female rats did not show the anticipated depressive-like behavior or cognitive decline after ISO, our data indicated regional effects on neuroinflammation and BDNF expression in the hippocampus, that were merely normalized by both WBV and exercise. Therefore, apart from the potential concern about the lack of cardiac collagen reduction, WBV may provide a relevant alternative for physical exercise.

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Section: E Ects On the Heartmentioning

confidence: 98%

“…More specifically, it may affect synaptic morphology and function. Loss of PNN is often observed in neurodegenerative diseases, as reviewed by Bonneh-Barkay and Wiley (Bonneh- Barkay and Wiley, 2009). Moreover, PNNs around hippocampal interneurons can resist destruction by activated microglia (Schuppel et al, 2002).…”

Section: E Ects On the Heartmentioning

confidence: 99%

Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior

Tóth

Oroszi²,

Nyakas³

et al. 2023

Front. Aging Neurosci.

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“…The aim of the present study was to compare WBV to exercise early after surgery. WBV and exercise share systemic effects, including increased muscle strength (38)(39)(40), and improved wound healing, as well as effects on the brain, such as increased neurotrophic factors (41,42), and cognitive improvement (31,43,44). As reviewed by Alam and coworkers (45), WBV is regarded as a neuromuscular training method to be used as an alternative to conventional training and therapy.…”

Section: Wbv and Exercisementioning

confidence: 99%

Hippocampal collagen as a potential target for post-surgical treatment; effects of whole-body vibration and exercise

Keijzer

Oberman

Oroszi

et al. 2022

Preprint

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Peripheral surgery may evoke neuroinflammation, associated with neuronal damage and consequently mental health problems. However, anti-inflammatory treatment showed limited therapeutic efficacy. Preservation of neuron integrity during neuroinflammation, by targeting their protective collagen sheet, may provide an alternative strategy. Whole-body vibration (WBV) and exercise combine anti-inflammatory and collagen-increasing effects in the periphery. The present study aimed to explore the therapeutic efficacy of postoperative WBV and exercise on hippocampal neuroinflammation and collagen expression. Three months old male Wistar rats underwent abdominal surgery. Starting from one day after surgery, rats were submitted to WBV (10 min, once or twice daily, 30 Hz), running exercise (30 min, daily), or pseudo WBV/exercise, for two weeks. Rats were sacrificed and brain tissue was collected and processed for (immuno)histochemistry. Hippocampal microglia activity, total collagen content, and expression of fibrous and non-fibrous collagen subtypes were analysed. Surgery was associated with increased microglia activity in the CA1 area, which was only partly reversed by the interventions. Surgery specifically reduced total collagen expression in the CA1 area, which was restored by both WBV and exercise. Collagen I was absent in the hippocampal granular layers. The surgery-induced decrease in collagen III expression in the CA1 area was not affected by either WBV or exercise. However, surgery increased collagen III in the CA2 (ns), CA3 and DG. Exercise, and to a lower extent WBV, seemed to (partly) reverse this effect. Collagen IV expression was not altered by surgery, but increased by WBV. No significant effects were observed on collagen VI expression. WBV as well as exercise restored the surgery-induced declined collagen expression, while partly reversing microglia activation in the CA1 area. Moreover, effects on collagen appeared to be subtype- and region-specific, with overall similar effects of WBV and exercise. Nevertheless, the neuroprotective potential of postoperatively altered brain collagen needs further investigation.

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“…Several animal studies support a positive impact of WBV on cognition and the brain [ 20 – 22 ]. After WBV training, mice showed improvements in memory and learning performance using novel object recognition [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of side-alternating Whole-Body Vibration on cognitive function of young adults

et al. 2023

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Recent research in rodents and humans revealed that Whole-Body Vibration (WBV) is beneficial for cognitive functions. However, the optimal WBV conditions are not established: contrary to vertical WBV, side-alternating WBV was not investigated before. The present study investigated the short-term effects of side-alternating WBV in standing and sitting posture on specific cognitive function of young adults. We used a balanced cross-over design. Sixty healthy young adults (mean age 21.7 ± 2.0 years, 72% female) participated. They were exposed to three bouts of two-minute side-alternating WBV (frequency 27 Hz) and three control conditions in two different sessions. In one session a sitting posture was used and in the other session a standing (semi-squat) posture. After each condition selective attention and inhibition was measured with the incongruent condition of the Stroop Color-Word Interference Test. WBV significantly (p = 0.026) improved selective attention and inhibition in the sitting posture, but not in the standing posture. The sitting posture was perceived as more comfortable, joyous and less exhaustive as compared to the standing posture. This study demonstrated that side-alternating WBV in sitting posture improves selective attention and inhibition in healthy young adults. This indicates that posture moderates the cognitive effect of WBV, although the effects are still small. Future studies should focus on the working mechanisms and further optimization of settings, especially in individuals who are unable to perform active exercise.

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Beneficial effects of whole-body vibration exercise for brain disorders in experimental studies with animal models: a systematic review

Cited by 10 publications

References 92 publications

Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior

Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior

Hippocampal collagen as a potential target for post-surgical treatment; effects of whole-body vibration and exercise

Short-term effects of side-alternating Whole-Body Vibration on cognitive function of young adults

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