Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria

LeBlanc, Jean Guy; Chain, Florian; Martín, Rebeca; Bermúdez‐Humarán, Luis G.; Courau, Stéphanie; Langella, Philippe

doi:10.1186/s12934-017-0691-z

Cited by 658 publications

(495 citation statements)

References 85 publications

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“…The role of genus Prevotella in NAFLD is still controversial in human study. Several previous studies indicated that the abundance of Prevotella was reduced in the patients with NAFLD, but the reversed findings were observed by other group . The differences in environmental conditions and dietary intake might be also the crucial factors affecting the abundance of Prevotella …”

Section: Discussionmentioning

confidence: 85%

Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT‐1/Nrf‐2 and Gut Microbiota in Rats

Chen

Lin

Lin³

et al. 2018

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 85%

Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT‐1/Nrf‐2 and Gut Microbiota in Rats

Chen

Lin

Lin³

et al. 2018

Molecular Nutrition Food Res

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“…A recent study indicated that the incubation of primary murine L cells with a concentration of propionate at 1.0 mmol L –1 achieved the same level of PYY secretion and about 73% of the level of GLP‐1 secretion compared to the effects of incubating cells at a propionate concentration of 50.0 mmol L –1 , which may indicate the dosage‐independence of propionate impact in cell culture. Another recent study found that 62% of infused propionate was used as gluconeogenic substrate, suggesting that, before arriving at the liver, the available propionate can be efficiently converted to monosacharide in the intestine . More importantly, propionate is highly involved in the gluconeogenesis pathways in the intestine and this process is triggered by the existence of butyric acid, because butyrate rather than propionate can directly activate genes expression associated with intestinal gluconeogenesis in enterocytes, demonstrating the interacting‐regulatory mechanism between SCFAs involved in cell metabolism.…”

Section: Discussionmentioning

confidence: 99%

Abundance of Probiotics and Butyrate‐Production Microbiome Manages Constipation via Short‐Chain Fatty Acids Production and Hormones Secretion

Zhuang

Shang

et al. 2019

Molecular Nutrition Food Res

107

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Scope The characteristics of gut microbiota and host metabolism are hypothesized to be associated with constipation status, but the regulation mechanism is not fully understood. Thus, the current study investigates the effect of constipation symptoms on gut functionality following the modulation of gut microbiota and metabolites via dietary fiber intervention. Methods and results Constipation causes a significantly reduced short‐chain fatty acids (SCFAs) production and a higher level of iso‐butyrate. The feces of constipated people are characterized with inhibited Faecalibacterium, Ruminococcaceae and Roseburia abundance. Desulfovibrionaceae is identified to be an important endotoxin producer in constipated patients, and a butyrate‐enriched SCFAs profile achieved by dietary fiber supplement accelerates gastrointestinal transit and increases the thickness of the mucosal layer, possibly through triggering the secretion of colonic hormones and enhancing the expression of tight junction proteins for maintaining intestinal barrier integrity. More importantly, an interacting regulatory mechanism among SCFAs, in particular butyrate and propionate, may be involved in signaling between the microbiome and host cells in the colon. Conclusion Gut microbiota, characterized with enriched butyrate‐producing and depressed Desulfovibrionaceae bacteria, attenuates constipation symptoms through promoting intestinal hormones secretion and maintaining gut barrier integrity.

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“…It has been reported that some commensal bacterial species and probiotic bacteria can produce many kinds of vitamins, such as vitamins in the B and K groups, folate, and nicotinic acid, which are directly involved in essential energy metabolism in the gut [30,31]. VSL#3 is manufactured with a carefully designed formulation of billions of eight strains of live freeze-dried lactic acid bacteria.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Aggravates Intestinal Epithelial Barrier Dysfunction in Rats with Experimental Uremia

Liang¹,

Liu²,

Liu³

et al. 2018

Kidney Blood Press Res

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Background/Aims: Previous studies have shown that homocysteine (Hcy) is an important intestinal-derived uremic toxin. However, whether Hcy is involved in the epithelial barrier dysfunction observed in uremia remains unclear. This study aimed to investigate the effect of Hcy on intestinal permeability and intestinal barrier structure and function in adenine-induced uremic rats. Methods: Sprague-Dawley rats were divided into five groups: normal control (group NC), Hcy (group H), uremia (group U), uremia + Hcy (group UH), and uremia + Hcy + VSL#3 (group UHV). Experimental uremia was induced by intragastric adenine administration, and Hcy was injected subcutaneously. The animal models were assessed for renal function and pathological tissue staining. The pathological changes of intestinal tissue were observed by hematoxylin and eosin staining and electron microscopy. The serum and intestinal tissue levels of Hcy, interleukin (IL)-6, tumor necrosis factor (TNF)-α, superoxide dismutase (SOD), and malondialdehyde (MDA) as well as serum endotoxin and intestinal permeability were assessed. The levels of the tight junction proteins claudin-1, occludin, and zonula occludens-1 (ZO-1) were assessed by western blotting. Results: Blood analyses and renal pathology indicated that experimental uremia was induced successfully. Pathological damage to intestinal structure was most obvious in group UH. Serum and tissue Hcy, serum endotoxin, and intestinal permeability were significantly elevated in group UH. The protein levels of claudin-1, occludin, and ZO-1 were decreased to various degrees in group UH compared with groups NC, H, and U. The serum and tissue levels of IL-6, TNF-α, and MDA were significantly increased, while SOD activity was markedly decreased. Supplementation with the probiotic VSL#3 improved these parameters to various degrees and up-regulated the abundance of tight junction proteins, which indicated a role for Hcy in the increase of intestinal permeability and destruction of the epithelial barrier in uremia. Conclusion: Hcy aggravates the increase of intestinal permeability and destruction of the epithelial barrier by stimulating inflammatory and oxidative damage. Probiotic administration can ameliorate this damage by reducing the levels of Hcy-induced inflammation and oxidation.

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Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria

Cited by 658 publications

References 85 publications

Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT‐1/Nrf‐2 and Gut Microbiota in Rats

Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT‐1/Nrf‐2 and Gut Microbiota in Rats

Abundance of Probiotics and Butyrate‐Production Microbiome Manages Constipation via Short‐Chain Fatty Acids Production and Hormones Secretion

Homocysteine Aggravates Intestinal Epithelial Barrier Dysfunction in Rats with Experimental Uremia

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