Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis

Anandakumar, Pandi; Jagan, Sundaram; Kamaraj, S.; Ramakrishnan, G.; Titto, A. A.; Devaki, Thiruvengadam

doi:10.1211/jpp.60.6.0017

Cited by 22 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the termination of the study (38 weeks), capsaicin feeding during either the initiation or promotion phase reduced the frequency of tongue squamous cell papillomas and squamous cell carcinomas (NQO alone, 9/15 rats with tongue tumors; NQO plus 10 weeks capsaicin, 5/17 rats with tongue tumors [not significant]; NQO plus 28 weeks of capsaicin, 3/14 rats with tongue tumors [p<0.05]). In a series of closely related experiments using Swiss albino mice, capsaicin was shown to exert its chemoprotective effects via several different mechanisms against benzo(a)pyrene (BP)-induced lung cancer (Anandakumar et al 2008;Anandakumar et al 2008aAnandakumar et al , 2008bAnandakumar et al2009aAnandakumar et al , 2009b; Anandakumar, P., Kamaraj, S., Jagan, S., Ramakrishnan, G., Naveenkumar, et al 2009). Due to the closely related nature of methods and somewhat overlapping results, key results from all 8 publications are grouped into one entry in Table 4.…”

Section: Teel and Huynh 1999mentioning

confidence: 99%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

View full text Add to dashboard Cite

Human exposure to capsaicin, the most abundant pungent chili pepper component, is ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in in vitro and in vivo genotoxicity and carcinogenicity assays. The capsaicin tested in older studies was often from pepper plant extracts and included other capsaicinoids and diverse impurities. Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of capsaicin is quite low and that the purity of capsaicin is important. Several small epidemiological studies suggest a link between capsaicin consumption and stomach or gall bladder cancer, but contamination of capsaicin-containing foods with known carcinogens renders their interpretation problematic. The postulated ability of capsaicin metabolites to damage DNA and promote carcinogenesis remains unsupported. Anticancer activities of capsaicin have been widely reported, as it inhibits the activity of carcinogens and induces apoptosis in numerous cancer cell lines in vitro and explanted into rodents. Diverse mechanisms have been postulated for capsaicin's anticancer properties. One hypothesis is that inhibition of cytochrome P450 enzymes-particularly CYP2E1-retards carcinogen activation but is contradicted by the low potency of capsaicin for CYP inhibition. The potential for dietary capsaicin to act as a chemopreventative is now widely postulated.

show abstract

Section: Teel and Huynh 1999mentioning

confidence: 99%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

View full text Add to dashboard Cite

show abstract

“…We have recently reported the chemopreventive action of CAP in modulating pulmonary antioxidant defense system and stabilizing mitochondrial enzyme system in lung cancer [7,10]. Our studies have also proved the influence of CAP on modulating lipid peroxidation, membrane‐bound enzymes and glycoprotein profile during lung carcinogenesis [11].…”

Section: Introductionmentioning

confidence: 79%

“…Our results are in agreement with these findings as we have observed increased activities of lysosomal proteases cathepsin‐D, cathepsin‐B, together with β‐ d ‐glucosidase, β‐ d ‐galactosidase, β‐ d ‐glucuronidase, β‐ d ‐ N ‐acetylglucosaminidase and acid phosphatase in the lung and serum of animals having cancer. CAP has been reported to possess antioxidant/free radical‐quenching property and inhibit free radical‐mediated oxidative stress [11]. CAP, by its antiperoxidative effect, traps peroxyl radical and acts by scavenging free radicals and quenching lipid peroxidative chains [41].…”

Section: Discussionmentioning

confidence: 99%

Lysosomal abnormalities during benzo(a)pyrene‐induced experimental lung carcinogenesis – defensive role of capsaicin

Anandakumar

Kamaraj

Jagan

et al. 2009

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

The objective of the present study was to investigate whether lysosome is a target in benzo(a)pyrene-induced, oxidative stress-mediated lung cancer in Swiss albino mice and the plausible role of the phytochemical substance capsaicin in mitigating lysosomal damage. Oxidative stress was assessed based on the level of carbonyl content. The activities of lysosomal proteases like cathepsin-D, cathepsin-B, beta-D-glucosidase, beta-D-galactosidase, beta-D-glucuronidase, beta-D-N-acetylglucosaminidase and acid phosphatase were assessed to evaluate lysosomal function. Administration of benzo(a)pyrene (50 mg/kg body weight) to mice induced a increase in the activities of lysosomal enzymes and oxidative stress was evident by the increase in carbonyl content. Treatment with capsaicin (10 mg/kg body weight) decreased carbonyl content and restored the activities of lysosomal enzymes to near normalcy. Transmission electron microscopic study of lysosomes further showed the defensive action of capsaicin against the lysosomal damage caused in benzo(a)pyrene-induced lung cancer. From the present study, it can be concluded that lysosomal damage is an indispensable event in benzo(a)pyrene-induced lung cancer, and capsaicin was able to effectively prevent it, which proves the chemoprotective effect of capsaicin against benzo(a)pyrene-induced experimental lung carcinogenesis.

show abstract

“…(De and Ghosh, 1993). Studies from our laboratory have also revealed the chemopreventive action of CAP in different dimensions (Anandakumar et al, 2008a); (Anandakumar et al, 2008b); (Anandakumar et al, 2008c).…”

Section: Introductionmentioning

confidence: 84%

Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma

et al. 2009

View full text Add to dashboard Cite

Spices and vegetables possess antioxidant activity that can be applied for preservation of lipids and lower lipid peroxidation in biological systems. In the present study, we have investigated the effect of capsaicin on lipid metabolism during benzo(a)pyrene induced lung cancer in Swiss albino mice. Benzo(a)pyrene (50 mg/kg wt) induced lung cancer animals showed abnormal changes in the tissue and serum lipids, lipoproteins and lipid metabolizing enzymes. Treatment with capsaicin (10 mg/kg body wt) remarkably attenuated all the above alterations and restored normalcy. These findings reveal the chemomodulatory potential of capsaicin in attenuating the alterations in lipid metabolism during experimental lung carcinogenesis.

show abstract

Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis

Cited by 22 publications

References 40 publications

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

Lysosomal abnormalities during benzo(a)pyrene‐induced experimental lung carcinogenesis – defensive role of capsaicin

Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma

Contact Info

Product

Resources

About