Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats

Kempaiah, Rayavara K.; Srinivasan, Krishnapura

doi:10.1016/j.jnutbio.2005.09.005

Cited by 74 publications

(56 citation statements)

References 40 publications

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“…Our studies have shown that the structural integrity of red blood cells and hence the osmotic fragility are affected in hypercholesterolemic situations [5]. Slight resistance to osmotic fragility has also been observed in rats fed a highfat diet [6]. Dietary hypolipidemic spices were evidenced to counter these changes in the osmotic sensitivity of erythrocytes to a significant extent [6].…”

Section: Introductionmentioning

confidence: 86%

“…Slight resistance to osmotic fragility has also been observed in rats fed a highfat diet [6]. Dietary hypolipidemic spices were evidenced to counter these changes in the osmotic sensitivity of erythrocytes to a significant extent [6]. In the current study, we examined whether a high-fat (30%) diet would have any detrimental influence on the antioxidant status of red blood cells and the liver, and evaluated the beneficial influence, if any, of dietary hypolipidemic spices on the antioxidant molecules and antioxidant enzymes of erythrocytes and liver tissue.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Dietary Curcumin, Capsaicin and Garlic on the Antioxidant Status of Red Blood Cells and the Liver in High-Fat-Fed Rats

Kempaiah¹,

Srinivasan²

2004

Ann Nutr Metab

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Background/Objective: An animal study was carried out to examine the beneficial influence of known hypolipidemic spice principles – curcumin and capsaicin – and the spice garlic on the antioxidant status of red blood cells and liver tissue in hyperlipidemic rats. Methods: Rats were rendered hyperlipidemic by maintaining them on a high-fat (30%) diet for 8 weeks. Spice principles – curcumin (0.2%) or capsaicin (0.015%) – or garlic (2.0%) were included in the diets of separate animal groups. Erythrocytes isolated at the end of the study were analyzed for intracellular antioxidant molecules and antioxidant enzymes. Results: Intracellular total thiols in the erythrocytes of high-fat-fed rats were depleted significantly (16%). Similarly, the intracellular glutathione content in erythrocytes was depleted in high-fat-fed rats (28%). The concentration of lipid peroxides in the erythrocytes (intracellular as well as membrane) induced by H₂O₂ was significantly higher in the high-fat-fed group. Curcumin (0.2%) or capsaicin (0.015%) or garlic (2.0%) in the diet which produced the hypotriglyceridemic effect were also effective in reducing oxidant stress, which was indicated by a significant countering of the depleted intracellular antioxidants – total thiols and glutathione – and elevated lipid peroxides in erythrocytes. The elevated lipid peroxide in blood plasma due to the high-fat diet was also significantly countered by the spice treatments. The severely depleted hepatic glutathione in high-fat treatment was also effectively reversed by dietary curcumin, capsaicin and garlic. Conclusions: Thus, dietary hypolipidemic spices were effective in reducing the oxidant stress, which was indicated by countering the depleted antioxidant molecules and antioxidant enzymes in erythrocytes and liver, and decreasing the elevated lipid peroxide content.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Influence of Dietary Curcumin, Capsaicin and Garlic on the Antioxidant Status of Red Blood Cells and the Liver in High-Fat-Fed Rats

Kempaiah¹,

Srinivasan²

2004

Ann Nutr Metab

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“…Thus, there is a growing attention on the way to improve obesity using phyto-nutrient that does not cause side-effects, among which garlic is known to effective for the control of lipid metabolism and obesity [1,16,24,31,51]. A major bioactive substances of garlic (Allium sativum L.) are an organic sulfur compounds containing allicin [11,18,22], which has the cardioprotective function among others [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

Lee¹,

Kim²,

Ryu³

et al. 2011

Journal of Life Science

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This study tested the anti-obesity and hypolipidemic effects of red garlic extract in obese rats induced by a high fat diet over a period of 4 weeks. Red garlic extract of 15 brix was added in 1, 3, 5 and 7% ratios in diets. The obesity index and body fat content significantly decreased in rats fed a diet with over 3% red garlic extract compared to the control group. There was no significant difference in weight of visceral and epididymal fat in rats fed red garlic extract. Total lipid and triglyceride levels in serum were significantly decreased in a dose-dependent manner, and AI and CRF also fell. ALT and AST activities in groups fed red garlic extract were decreased compared to the control group. Total lipid level in liver tissue of the groups fed 5-7% red garlic extract exhibited a significant decrease compared to the control group. Total cholesterol and triglyceride levels in feces were significantly increased in rats fed a diet with over 5% red garlic extract. Lipid peroxide levels were significantly decreased in the groups fed diets with 5-7% red garlic and antioxidant activity in serum was significantly increased in the group fed a diet with 7% red garlic extract compared to the control group. Our results suggest that red garlic extract could have anti-obesity and hypolipidemic effects for suppressing obesity index and decreasing lipid profiles. IntroductionAs the choice for a high-calorie and high-fat diet increases due to the economic stability and affluence, so does the occurrence of metabolic disease caused by over-weight [27]. Obesity is the condition under which surplus energy is accumulated as lipids, which is attributable to the increase of energy intake and the decrease of consumption. From the balance is lost, obesity or hyperlipidemia develops, leading to a serious disease. In Korea, the social and economic cost incurred by the increase of obese population rises annually. Given that 40% of people who die by circulating system disease including atherosclerosis, cerebro-, cardio-vascular complications, hypertention, diabetes and functional depression of certain organs are obese, it is necessary to take a fundamental measure to improve the situation [47].Although the drug therapy proved to be effective as a behavior correction therapy used for the control of lipid metabolism in obese, it accompanies side-effects such as headaches, insomnia, and vomiting [29]. Thus, there is a growing attention on the way to improve obesity using phyto-nutrient that does not cause side-effects, among which garlic is known to effective for the control of lipid metabolism and obesity [1,16,24,31,51]. A major bioactive substances of garlic (Allium sativum L.) are an organic sulfur compounds containing allicin [11,18,22], which has the cardioprotective function among others [25]. Reportedly in Korea, the bioactive effect is elevated through the heat-treatment which turns fresh garlic into aged black garlic [22,46] supplemented with 5% red garlic extract, RG-7: supplemented with 7% red garlic extract. production of t...

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“…Increased oxidative stress in high-fat fed rats might have contributed to the decreased Ca 2+ , Mg 2+ -ATPase activity 18 . Reduction in the activity of these enzymes might be due to enhanced lipid peroxidation by free radicals.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2015

IJPSR

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ABSTRACT:The aim of the present study is to evaluate the protective effect of flower extract of Michelia champaca on membrane bound enzyme (serum ATPase) levels on male albino rats. The membrane bound enzymes (Ca 2+ ATPase, Mg 2+ ATPase, Na+K+ ATPase) levels of methanolic flower extract of Michelia champaca at a dose of 300 mg/kg was evaluated during exposure to CCl 4 . There was a significant decrease in membrane bound enzymes such as Ca 2+ ATPase, Mg 2+ ATPase, Na+K+ ATPase was observed in CCl4 treated rats. Therapeutic treatment with plant extract has significantly ameliorated to near normalcy in the curative group. These results of the study concluded that Michelia champaca was found to be effective in preventing the biochemical abnormalities caused by toxins.

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Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats

Cited by 74 publications

References 40 publications

Influence of Dietary Curcumin, Capsaicin and Garlic on the Antioxidant Status of Red Blood Cells and the Liver in High-Fat-Fed Rats

Influence of Dietary Curcumin, Capsaicin and Garlic on the Antioxidant Status of Red Blood Cells and the Liver in High-Fat-Fed Rats

Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

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