Beneficial role of vitamin D₃ in the prevention of certain respiratory diseases

Abstract

There is evidence of aberrations in the vitamin D-endocrine system in subjects with respiratory diseases. Vitamin D deficiency is highly prevalent in patients with respiratory diseases, and patients who receive vitamin D have significantly larger improvements in inspiratory muscle strength and maximal oxygen uptake. Studies have provided an opportunity to determine which proteins link vitamin D to respiratory pathology, including the major histocompatibility complex class II molecules, vitamin D receptor, vitamin D-binding protein, chromosome P450, Toll-like receptors, poly(ADP-ribose) polymerase-1, and the reduced form of nicotinamide adenine dinucleotide phosphate. Vitamin D also exerts its effect on respiratory diseases through cell signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the Wnt/β-catenin signaling pathway, prostaglandins, reactive oxygen species, and nitric oxide synthase. In conclusion, vitamin D plays a significant role in respiratory diseases. The best form of vitamin D for use in the treatment of respiratory diseases is calcitriol because it is the active metabolite of vitamin D3 and modulates inflammatory cytokine expression. Further investigation of calcitriol in respiratory diseases is needed.

Correlation of vitamin D receptor with bronchial asthma in children

“…VDR gene is located on q12-23 loci on chromosome 12, which can be combined with VDR receptor in the target cells, so as to adjust the structure of the corresponding gene ( 17 ). It has been reported that ( 18 , 19 ) the expression of VDR is associated with pulmonary micro-environment development, that is, when there is a lack of VDR, while it is simulated by inflammatory factor, the simulation of lung inflammation is relatively light, revealing that the lack of VDR plays a protective role on asthma. In this study, the level of vitamin D was lower in the observation group than that in the control group (P<0.05); the level of total serum IgE was higher in the observation group than that in the control group (P<0.05), indicating that vitamin D can mediate body's immunity, which is conducive to assessing the severity of the disease.…”

VDR gene polymorphisms are associated with the increased susceptibility to COVID‐19 among iranian population: A case‐control study

“…Many studies show that vitamin D plays a role in regulating immune cells and modulating the immune response. In several studies, the anti‐inflammatory and immunomodulatory effect of vitamin D on inflammatory diseases, particularly on respiratory viruses such as influenza, respiratory syncytial virus (RSV), Middle East Respiratory Syndrome Coronavirus (MERS‐CoV), SARS‐CoV‐1 and rhinovirus, is shown (Greiller & Martineau, 2015 ; Lương & Nguyễn, 2013 ; Sutaria et al., 2014 ).…”

Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis

“…Moreover, nucleotide methylation can also offer antibiotic resistance, such as 16S rRNA methyltransferase in Enterobacteriaceae 38 . It has been previously been reported that the upregulation of thiamine phosphate synthase can cause an increase in resistance to multiple stresses in Schizosaccharomyces , and thiamine supplementation might also contribute to chemotherapy resistance in cancer cells 39, 40 . Another key upregulated gene glmM (2.6-fold change), encoding phosphoglucosamine mutase, has been demonstrated to contribute to the resistance of Streptococcus , and is the drug target for regulating resistance.…”