Benefits and Risks of Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease Classified by Blood Eosinophil Counts

Saito, Zenya; Yoshida, Masahiro; Kojima, Ayako; Tamura, Kentaro; Hasegawa, Toshiyuki; Kuwano, Kazuyoshi

doi:10.1007/s00408-020-00397-4

Cited by 4 publications

(2 citation statements)

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“…This finding may provide insight into using oral and inhaled steroids in patients with AECOPD based on the eosinophil count to avoid risks associated with the indiscriminate use of steroids in such patients. 23 There was no difference in the need for mechanical ventilation between the groups (p = 0.32). In the present study, the mortality outcome was not assessed because of the small sample size; however, previous studies have suggested that eosinophilic AECOPD is associated with a lower inpatient mortality rate, but the data are conflicting.…”

Section: Discussionmentioning

confidence: 86%

“…Moreover, this finding may provide insight into using oral and inhaled steroids in patients with AECOPD based on the eosinophil count and, thus, help avoid risks associated with the indiscriminate use of steroids in such patients. 24 Additionally, no difference in the need for mechanical ventilation between the groups was noted ( P = 0.32).…”

Section: Discussionmentioning

confidence: 89%

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Elevated Peripheral Blood Eosinophils during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Sibani

Alawi

Aghbari

2022

Sultan Qaboos Univ Med J

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Objectives: An elevated peripheral blood eosinophil (PBE) count during acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a potential predictor of treatment responsiveness and future exacerbation risk. This study aimed to evaluate the prevalence and clinical significance of elevated PBE counts in hospitalized patients with AECOPD in Oman. Methods: This single-center retrospective study included all patients with AECOPD who were admitted to Sultan Qaboos University Hospital between January 2017 and July 2019. The patients were classified as having eosinophilic or noneosinophilic AECOPD based on blood eosinophil counts. An elevated eosinophil count was defined as a blood eosinophil count > 0.3 × 109 cells/L on admission. The length of hospital stay, use of oral and inhaled steroids, number of readmissions in a year, and use of mechanical ventilation on admission were compared between the eosinophilic and non-eosinophilic AECOPD groups. Results: Of the 102 patients included in the study, 42.2% had eosinophilic AECOPD. The eosinophilic AECOPD group had a reduced length of hospital stay (P = 0.02) but an increased risk of readmission in a year (P = 0.04). Most patients in both the groups were treated with inhaled and oral steroids. The need for mechanical ventilation did not differ between the groups. Conclusion: Eosinophilia is highly prevalent in patients with AECOPD and is associated with a reduced length of hospital stay but an increased risk of readmission in a year. It can be used as a surrogate marker to predict the health outcomes of patients with AECOPD and select treatment options. Keywords: Chronic Obstructive Pulmonary disease (COPD); Eosinophils; Steroids; length of stay; hospital readmission.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 89%