Benefits of l-alanine or l-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity

Araújo, Thiago R.; Freitas, Israelle N.; Vettorazzi, Jean Franciesco; Batista, Thiago M.; Santos-Silva, Junia Carolina; Bonfleur, Maria Lúcia; Balbo, Sandra Lucinei; Boschero, Antônio Carlos; Carneiro, Everardo M.; Ribeiro, Rosane Aparecida

doi:10.1007/s00394-016-1245-6

Cited by 49 publications

(30 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulin resistance and reduced glucose tolerance in rodents due to MSG consumption raise concerns about the development of obesity in MSG consuming humans. The same study revealed that MSG intake causes a disrupted energy balance by increasing the palatability of food and disturbing the leptin-mediated hypothalamus signalling cascade, potentially leading to obesity (Araujo et al, 2017[ 2 ]; He et al, 2011[ 5 ]). In a study into the inflammatory profile of MSG induced obesity, it has been shown that MSG triggers micro-RNA (mRNA) expression of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), resistin and leptin in visceral adipose tissue.…”

Section: ⁯⁯mentioning

confidence: 99%

Extensive use of monosodium glutamate: a threat to public health?

Niaz

Zaplatić

Spoor

2018

EXCLI Journal; 17:Doc273; ISSN 1611-2156

View full text Add to dashboard Cite

Section: ⁯⁯mentioning

confidence: 99%

Extensive use of monosodium glutamate: a threat to public health?

Niaz

Zaplatić

Spoor

2018

EXCLI Journal; 17:Doc273; ISSN 1611-2156

View full text Add to dashboard Cite

“…Animal studies demonstrated neonatal MSG consumption caused obesity along with Insulin resistance and reduced glucose tolerance in later life of rodents. 4 In a placebo control study using MSG dose ranging from 57 -150 mg/kg was resulted in muscle pain and change in mechanical sensitivity in human. 5 Scientists have reported high dose of MSG 75 gms per kg in human elevates systolic blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Effect of Neonatal Exposure of Monosodium Glutamate in Kidney of Albino Mice – A Histological Study

Bhattacharya¹,

Ghosh²

2019

Nep. Med. Coll. J.

View full text Add to dashboard Cite

Monosodium Glutamate (MSG) is a commonly used food additive. Scientists have found that MSG has toxic effects in several tissues and organs like neurons, liver, testes, ovary, kidneys etc due to oxidative stress both after exposure in neonatal period as well as in adult animal models. Although various reports have suggested that MSG has damaging effect in kidneys only few histological studies are available. This study was done to observe any histological changes in kidneys of albino mice after neonatal exposure with MSG. Study showed significant changes in weight and volume of kidneys in gross morphology. Increased urinary space and dilatation of proximal convoluted tubules (PCT) and distal convoluted tubules (DCT) were constant finding in experimental animals. There were loss of luminal microvilli and reduced height of lining cells of both PCT and DCT.

show abstract

“…Available evidence shows that physiological levels of arginine and NO decrease fat synthesis and promote the oxidation of fat in a tissue-specific manner [ 79 ]. L-arginine has been reported to prevent body fat accumulation in DIO by regulating pancreatic β-cell physiology [ 80 ]. Supplementation of arginine reduces adiposity and improves glucose tolerance in obese rodents and humans [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors

Rau

et al. 2018

Nutrients

View full text Add to dashboard Cite

Background: This study aimed at assessing the effect of a low-fat diet (LFD) in obese mice lacking toll–like receptors (Tlr) and understanding the expression and regulation of microRNAs during weight reduction. Methods: C57BL/6, Tlr5−/−, Tlr2−/− and Tlr4−/− mice were used in this study. A group of mice were fed with a high-fat diet (HFD) (58% kcal) for 12 weeks to induce obesity (diet-induced obesity, DIO). Another group that had been fed with HFD for eight weeks (obese mice) were switched to a low-fat diet (LFD) (10.5% kcal) for the next four weeks to reduce their body weight. The control mice were fed with a standard AIN-76A diet for the entire 12 weeks. The body weight of the mice was measured weekly. At the end of the experiment, epididymal fat weight and adipocyte size were measured. The differentially expressed miRNAs in the fat tissue was determined by next-generation sequencing with real-time quantitative reverse transcription polymerase chain reaction (RT–qPCR). Target prediction and functional annotation of miRNAs were performed using miRSystem database. Results: Switching to LFD significantly reduced the body weight and epididymal fat mass in the HFD-fed C57BL/6 and Tlr5−/− mice but not in Tlr2−/− and Tlr4−/− mice. Weight reduction significantly decreased the size of adipocytes in C57BL/6 but not in the Tlr knockout mice. In Tlr2−/− and Tlr4−/− mice, feeding with HFD and the subsequent weight reduction resulted in an aberrant miRNA expression in the epididymal fat tissue unlike in C57BL/6 and Tlr5−/−. However, target prediction and functional annotation by miRSystem database revealed that all the top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) database pathways of the dysregulated miRNAs during weight reduction in the C57BL/6 mice were also found in the regulated pathways of Tlr5−/−, Tlr2−/−, and Tlr4−/− strains. However, among these pathways, gene sets involved in arginine and proline metabolism and glutathione metabolism were mainly involved in the Tlr knockout mice but not in the C57BL/6 mice. Conclusions: In this study, we demonstrated that feeding of LFD leads to significant body weight reduction in C57BL/6 and Tlr5−/− mice, but not in Tlr2−/− and Tlr4−/− mice. Significant reduction in the size of adipocytes of epididymal fat was only found in C57BL/6, but not in Tlr5−/−, Tlr2−/−, and Tlr4−/− mice. The dysregulated miRNAs in Tlr2−/− and Tlr4−/− mice were different from those in C57BL/6 and Tlr5−/− strains. Among those miRNA-regulated pathways, arginine and proline metabolism as well as glutathione metabolism may have important roles in the Tlr knockout mice rather than in C57BL/6 mice.

show abstract

Benefits of l-alanine or l-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity

Abstract: Ala supplementation led to more pronounced metabolic improvements compared to Arg, possibly due to suppression of lipogenesis through activation of the AMPK/ACC pathway.

Cited by 49 publications

References 43 publications

Extensive use of monosodium glutamate: a threat to public health?

Extensive use of monosodium glutamate: a threat to public health?

Effect of Neonatal Exposure of Monosodium Glutamate in Kidney of Albino Mice – A Histological Study

Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors

Contact Info

Product

Resources

About