“Benifuuki” green tea, containing O -methylated EGCG, reduces serum low-density lipoprotein cholesterol and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: A double-blind, placebo-controlled randomized trial

Imbe, Hisashi; Sano, Hiroyuki; Miyawaki, Masahiro; Fujisawa, Reiko; Miyasato, Mai; Nakatsuji, Fumihiko; Haseda, Fumitaka; Tanimoto, Keiji; Terasaki, Jungo; Maeda‐Yamamoto, Mari; Tachibana, Hirofumi; Hanafusa, Toshiaki

doi:10.1016/j.jff.2016.05.004

Cited by 17 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the completion of this meta-analysis, additional RCTs investigating the effects of tea or cocoa products containing flavanols on lipid and anthropometric variables have been added to the existing literature [111,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183]. The heterogeneity of these trials remains high with population samples including mixed sexes and ages, obese, overweight, healthy, hyperlipidemic and/or diabetic subjects, etc.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

et al. 2017

View full text Add to dashboard Cite

Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…40,41) In addition, methylated catechins such as (−)-epigallocatechin-3-(3″-O-methyl) gallate (EGCG3Me) contained in the EALT were also known to play important role in reducing weight gain. 42) Taken together, (−)-epigallocatechin-3-gallate and (−)-epigallocatechin-3-(3″-O-methyl) gallate appear to be responsible for the anti-obesity effect of EALT.…”

Section: Discussionmentioning

confidence: 98%

Anti-obesity Effect of Halophyte Crop, <i>Limonium tetragonum</i> in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes

Kim

Heo

Rho

et al. 2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…Furthermore, the lectin-like oxidized low-density lipoprotein receptor-1 containing apolipoprotein B (LAB) levels in "Benifuuki" drinkers were significantly lower than those in the barley infusion group and the "Benifuuki" baseline LAB level. In subjects whose green tea intake was irregular, "Benifuuki" significantly reduced serum LDL cholesterol and LAB levels compared to those following barley infusion consumption [52].…”

Section: Technical Problems In Developing Functional Agricultural Promentioning

confidence: 91%

“…Some business operators are preparing to send notifications for lutein-rich spinach, and polyphenol-rich apple to CAA by utilizing the systematic reviews. rich satsuma mandarins [27][28][29][30], procyanidin rich apple [51], green tea rich in O-methylated catechin (epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3′′Me)) [52], various other catechins [53], resistant starch rich rice [54], and zinc-rich oyster [55]. The most recent scientific findings obtained through this project are outlined below.…”

Section: Agricultural Products Registered In the Ffcmentioning

confidence: 99%

Development of functional agricultural products utilizing the new health claim labeling system in Japan

Maeda‐Yamamoto

Ohtani

2018

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

In April 2015, Consumer Affairs Agency of Japan launched a new food labeling system known as "Foods with Function Claims (FFC)." Under this system, the food industry independently evaluates scientific evidence on foods and describes their functional properties. As of May 23, 2017, 1023 FFC containing 8 fresh foods have been launched. Meanwhile, to clarify the health-promoting effects of agricultural products, National Agriculture and Food Research Organization (NARO) implemented the "Research Project on Development of Agricultural Products" and demonstrated the risk reduction of osteoporosis of β-cryptoxanthin rich Satsuma mandarins and the anti-allergic effect of the O-methylated catechin rich tea cultivar Benifuuki. These foods were subsequently released as FFC. Moreover, NARO elucidated the health-promoting effects of various functional agricultural products (β-glucan rich barley, β-conglycinin rich soybean, quercetin rich onion, etc.) and a healthy boxed lunch. This review focuses on new food labeling system or research examining functional aspects of agricultural products.

show abstract

“Benifuuki” green tea, containing O -methylated EGCG, reduces serum low-density lipoprotein cholesterol and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: A double-blind, placebo-controlled randomized trial

Cited by 17 publications

References 32 publications

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

Anti-obesity Effect of Halophyte Crop, <i>Limonium tetragonum</i> in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes

Development of functional agricultural products utilizing the new health claim labeling system in Japan

Contact Info

Product

Resources

About