Benign and malignant giant cell tumors of bone.A clinicopathological analysis of the natural history of the disease

Hutter, R. V. P.; Worcester, Jane; Francis, Kenneth C.; Foote, Frank W.; Stewart, Fred W.

doi:10.1002/1097-0142(196207/08)15:4<653::aid-cncr2820150402>3.0.co;2-m

Cited by 209 publications

(73 citation statements)

References 4 publications

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“…The latter is locally aggressive with a high recurrence rate, and a potential for malignant transformation. 8 Some CGCGs of the jaws, despite an innocent histologic appearance, show an aggressive behavior and a tendency to recur. Ficarra et al considered that these lesions should be defined as 'aggressive giant cell granulomas' of the jaws, rather than giant cell tumor.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Central Giant Cell Granuloma of Mandible Transformed to an Enormous Vascular Lesion

Manekar¹

2012

JOFR

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Aggressive central giant cell granuloma (ACGCG) is usually found in younger patients and is painful, grows rapidly, larger overall, often causes cortical perforation, root resorption and has a tendency to recur. This article is a case report of ACGCG in mandible. A girl 12 years old had features of typical giant cell reparative granuloma in the anterior mandible. After incision biopsy, she reported after 11 months. The lesion had rapidly increased in size and vascularity to an enormous tumorlike mass with engorged vessels. The lesion was of enormous size and extensive expansion was high in vascularity. The cortices remained but thinned out and perforated despite of extensive expansion. The lesion was curetted resulting in loss of continuity of the mandible. The microvascular surgery with free fibula graft was done to reconstruct the mandible. This is report of rarest case of ACGCG with enormous increase in size and vascularity which was treated successfully and rehabilitated.

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Section: Discussionmentioning

confidence: 99%

Aggressive Central Giant Cell Granuloma of Mandible Transformed to an Enormous Vascular Lesion

Manekar¹

2012

JOFR

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“…The current literature describes this malignant transformation mainly as a high-grade spindle or pleomorphic sarcoma with or without osteoid production [1][2][3][4][5][7][8][9] . Dedifferentiation exhibiting low-grade morphology has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up

et al. 2010

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Giant cell tumour (gct) of bone is a locally aggressive benign tumour. It can, however, undergo dedifferentiation, either de novo or secondarily after local recurrence or radiation. Whether spontaneously occurring or induced by previous irradiation, this malignant transformation is typically defined as a high-grade anaplastic sarcoma devoid of giant cells. Dedifferentiation of gct into low-grade-appearing sarcoma has not been reported yet. Here, we describe the first case of dedifferentiated gct in the appearance of low-grade fibroblastic osteogenic sarcoma with distant bone metastases. This disease progression occurred without previous irradiation. We confirm the aggressive behaviour of this tumour despite the deceptively bland appearance of the malignant component. We also alert others to the importance of recognizing this rare histology to avoid underdiagnosis and subsequent undertreatment.

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“…The histological examination in the present case demonstrated high-grade osteosarcoma. Hutter et al (1962) and Dahlin et al (1970) defined "malignant giant-cell tumor" as a sarcoma either juxtaposed to the zone of a typical giant-cell tumor or occurring at the site of the previous benign GCT. Although such a juxtaposition was not clearly noted in the present case, the osteosarcoma had definitely occurred at the site of the previous benign GCT.…”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma Arising from Giant Cell Tumor of Bone Ten Years After Primary Surgery: A Case Report and Review of the Literature

Hashimoto

Hatori

Hosaka

et al. 2006

Tohoku J. Exp. Med.

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Giant cell tumor of the bone (GCT) is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells. GCT is a primary benign tumor but may evolve into a malignant tumor, usually after irradiation. We report a rare case of osteosarcoma arising ten years after the primary surgery for GCT without radiation. A 45-year-old woman presented with severe right knee pain after suffering contusion. Roentgenogram revealed a bone tumor in the lateral femoral condyle of the right knee. Histopathological examination demonstrated the features of GCT, and treatment consisted of curettage and bone grafting. Four months after the operation, multiple lung metastases of GCT occurred, which were treated by partial lobectomy. Ten years after the primary treatment, severe knee pain recurred. Roentgenogram and magnteic resonance imaging (MRI) demonstrated a destructive lesion in the lateral condyle of the right knee. Histopathological examination demonstrated a lacy pattern of osteoids and abnormal mitoses in the aggregated atypical mononuclear cells, indicating osteosarcoma. Despite above-knee amputation and chemotherapy, scapular and lung metastases developed and the patient died five months after above knee amputation. One may question whether the primary GCT contained some malignant cells. However, given the aggressiveness of the malignant tumor, this is unlikely. The recurrence of pain and aggravation of bone destruction many years after the primary treatment suggest malignant transformation of GCT. giant cell tumor; osteosarcoma; malignant transformation; long term

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Benign and malignant giant cell tumors of bone.A clinicopathological analysis of the natural history of the disease

Cited by 209 publications

References 4 publications

Aggressive Central Giant Cell Granuloma of Mandible Transformed to an Enormous Vascular Lesion

Aggressive Central Giant Cell Granuloma of Mandible Transformed to an Enormous Vascular Lesion

Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up

Osteosarcoma Arising from Giant Cell Tumor of Bone Ten Years After Primary Surgery: A Case Report and Review of the Literature

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