Benign Breast Disease

Amin, Amanda L.; Purdy, Anna; Mattingly, Joanne D.; Kong, Amanda L.; Termuhlen, Paula M.

doi:10.1016/j.suc.2013.01.001

Cited by 60 publications

(71 citation statements)

References 23 publications

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“…In this study, most groups improved in identifying the finding type, particularly normal and benign findings, after the educational course. Normal breast tissue and cysts represent common normal and benign causes of a palpable lump that do not require imaging follow-up or a biopsy (20). For most groups, correct recognition of a normal and benign finding type translated into reductions in unnecessary biopsy recommendations.…”

Section: Discussionmentioning

confidence: 99%

Improving Breast Ultrasound Interpretation in Uganda Using a Condensed Breast Imaging Reporting and Data System

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Improving Breast Ultrasound Interpretation in Uganda Using a Condensed Breast Imaging Reporting and Data System

et al. 2016

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“…Human benign and malignant breast diseases, including atypical hyperplasia, papilloma, fibroma and ductal carcinoma, are usually associated with inflammation (1,2). Benign breast conditions are common and the majority of breast changes are not cancer; however, certain benign diseases increase the risk of breast cancer, including atypical hyperplasia, which is a potential precursor of cancer (3).…”

Section: Introductionmentioning

confidence: 99%

Association of serum interleukin‑10, interleukin‑17A and transforming growth factor‑α levels with human benign and malignant breast diseases

Liu

Shen

et al. 2018

Exp Ther Med

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Abstract. Interleukin-10 (IL-10), interleukin-17A (IL-17A) and transforming growth factor α (TGF-α) have been implicated in the progression of breast cancer. However, the diagnostic and prognostic roles of these cytokines in ductal carcinoma remain unclear. The present study therefore aimed to determine the serum levels of IL-10, IL-17 and TGF-α in subjects with benign and malignant breast diseases and to evaluate the clinical significance of these cytokines in ductal carcinoma. Pre-operative serum samples were collected from 378 patients with breast disease and 70 healthy subjects. IL-10, IL-17A and TGF-α levels were measured using ELISA. Serum levels of these cytokine in patients with different breast diseases were evaluated. Furthermore, correlations between levels of these cytokines and the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in ductal carcinoma were determined. The results demonstrated that serum levels of IL-10 and IL-17A were significantly increased in subjects with atypical hyperplasia and ductal carcinoma. Furthermore, IL-10 and IL-17A levels were increased in patients with a more serious clinical tumor stage and tumors that were ER -and PR -. Furthermore, high serum levels of TGF-α were associated with HER2 + tumors. A strong positive correlation was identified between TGF-α and IL-17A levels. Therefore, the results of the current study revealed that elevated serum IL-10, IL-17A and TGF-α levels are strongly associated with ductal carcinoma, specifically with tumor stage. High serum levels of IL-10 and IL-17A were also associated with the negative expression of ER and PR in ductal carcinoma, and high serum levels of TGF-α were associated with the positive expression of HER2 in ductal carcinoma. Thus, serum cytokine levels may be measured to identify patients with a poor prognosis who may benefit from more aggressive management and treatment.

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“…Fibroadenomas are usually single, firm, rubbery masses with a well-circumscribed border (1). When they are found in children and adolescents they are called juvenile fibroadenomas (2).…”

Section: Introductionmentioning

confidence: 99%

Bilateral giant juvenile fibroadenomas of the breasts—a rare indication for bilateral skin reducing mastectomy

2016

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Benign Breast Disease

Cited by 60 publications

References 23 publications

Improving Breast Ultrasound Interpretation in Uganda Using a Condensed Breast Imaging Reporting and Data System

Improving Breast Ultrasound Interpretation in Uganda Using a Condensed Breast Imaging Reporting and Data System

Association of serum interleukin‑10, interleukin‑17A and transforming growth factor‑α levels with human benign and malignant breast diseases

Bilateral giant juvenile fibroadenomas of the breasts—a rare indication for bilateral skin reducing mastectomy

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