Benign lymphoepithelial cyst of parotid gland: Review and case report

Abstract

Benign lymphoepithelial cyst (BLC), also known as branchial cyst, is an infrequent lesion usually occurs in the parotid gland or the lateral cervical area including lymph nodes. It occurs due to the process of lymphocyte-induced cystic ductular dilatation and is always diagnosed postoperatively by histopathological examination (HPE). These dysontogenetic lesions are usually found in the lateral neck but can also be located in the salivary glands, mostly in the parotids. A 35-year-old male reported to Government Dental College, Indore, before 3 years, with a soft, nontender, gradually increasing, compressible diffuse swelling involving the left parotid gland for the last 9–10 months of size 3.5 cm × 2.5 cm × 4.5 cm at the time of presentation with normal Stensen's duct and facial nerve function. ELISA test was negative, biochemistry indicated high protein content of aspirated fluid and magnetic resonance imaging showed hypertense cystic fluid in both T1- and T2-weighted images, suggesting high protein or hemorrhage and negating a solid lesion. Superficial parotidectomy was done with nonincidental healing. HPE of excisional tissue revealed it to be BLC.

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

“…The histological findings in our case were in accordance with those reported in human medicine. The LEC was predominantly lined by a squamous epithelium surrounded by lymphoid tissue [1,3]. Although the tingible body macrophages, lymphocyte exocytosis, and multinucleated giant cells may be present [18], the latter was not demonstrated in our case.…”

“…It has mainly been discovered in the human head-and-neck region, such as the oral cavity and salivary glands (more commonly, the parotid and, rarely, the submandibular gland), most often in the lateral cervical area just below the angle of the mandible, including the lymph nodes. It rarely affects the thyroid gland, lungs, and pancreas [1].…”

“…It has been considered as nearly pathognomonic for HIV. In addition, its decreased incidence upon an antiretroviral treatment used as the first-line therapy has proved that this "linking" is not purely coincidental [1].…”

Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue

“…Normal tissue for the study was selected more than 5 mm far from the infiltrative edge of the tumor. This numerical criterion was applied because tissue that is at least 5 mm or more from invasive carcinoma is considered free of tumor cells when the adequacy of surgical margins is evaluated in the pathologic report 66,67 . One paraffin-embedded normal tongue tissue block per case was selected with informed consent to prepare tissue slides for histochemical and immunohistochemical analyses.…”

Branchial cleft cyst in the parotid gland in a human immunodeficiency virus-negative patient

“…In branchial lymphoepithelial cyst (BLEC), which also referred to as branchial cleft cyst, the remnant of a branchial arch develops into a cyst, causing swelling [1]. Branchial cleft cysts are classified into four groups depending on which branch cleft they originated from, with locations ranging from the external auditory canal (in first branchial cleft cysts) to the lower part of the neck (in fourth branchial cleft cysts).…”